PGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue

Adipose tissue secretes adipokines that mediate insulin resistance, a characteristic feature of obesity and type 2 diabetes. By differential proteome analysis of cellular models of insulin resistance, we identified progranulin (PGRN) as an adipokine induced by TNF-α and dexamethasone. PGRN in blood...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell metabolism 2012-01, Vol.15 (1), p.38-50
Hauptverfasser:	Matsubara, Toshiya, Mita, Ayako, Minami, Kohtaro, Hosooka, Tetsuya, Kitazawa, Sohei, Takahashi, Kenichi, Tamori, Yoshikazu, Yokoi, Norihide, Watanabe, Makoto, Matsuo, Ei-ichi, Nishimura, Osamu, Seino, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipokines - metabolism Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Dexamethasone - pharmacology Diet, High-Fat Insulin Resistance Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - pharmacology Interleukin-6 - metabolism Male Mice Mice, Inbred C57BL Mice, Obese Obesity - blood Obesity - metabolism Obesity - prevention & control Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Thiazolidinediones - pharmacology Tumor Necrosis Factor-alpha - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!