Aged Red Garlic Extract Reduces Cigarette Smoke Extract‐induced Cell Death in Human Bronchial Smooth Muscle Cells by Increasing Intracellular Glutathione Levels
Increasing antioxidant capacity has been proposed as a promising strategy to prevent cigarette smoke‐induced lung diseases. This study tested whether garlic extracts prevented cigarette smoke extract (CSE)‐induced cell death in human bronchial smooth muscle cells (HBSMCs). Garlic extracts were prepa...
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| Veröffentlicht in: | Phytotherapy research 2012, Vol.26 (1), p.18-25 |
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| creator | Jeong, Yi‐Yeong Park, Hye‐Jin Cho, Young‐Woo Kim, Eun‐Jin Kim, Gyu‐Tae Mun, Yun‐Ja Lee, Jong Deog Shin, Jung‐Hye Sung, Nak‐Ju Kang, Dawon Han, Jaehee |
| description | Increasing antioxidant capacity has been proposed as a promising strategy to prevent cigarette smoke‐induced lung diseases. This study tested whether garlic extracts prevented cigarette smoke extract (CSE)‐induced cell death in human bronchial smooth muscle cells (HBSMCs). Garlic extracts were prepared from fresh raw garlic (FRG), aged black garlic (ABG) and aged red garlic (ARG). Treatment of HBSMCs with 10% CSE induced cell death accompanied by activation of caspase. Of the garlic extracts, treatment with ARG extract reduced CSE‐induced cell death. The combination of ARG extract with CSE attenuated the CSE‐induced reduction in glutathione (GSH) content, generation of reactive oxygen species (ROS) and induction of heme oxygenase‐1 expression compared with CSE treatment without ARG extract. Furthermore, the combination of L‐BSO, a GSH synthesis inhibitor, with ARG and CSE extracts failed to increase the intracellular GSH content and cell viability. Taken together, these results demonstrate that ARG extract reduces CSE‐induced cell death by increasing GSH content and reducing ROS generation in HBSMCs. |
| doi_str_mv | 10.1002/ptr.3502 |
| format | Article |
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This study tested whether garlic extracts prevented cigarette smoke extract (CSE)‐induced cell death in human bronchial smooth muscle cells (HBSMCs). Garlic extracts were prepared from fresh raw garlic (FRG), aged black garlic (ABG) and aged red garlic (ARG). Treatment of HBSMCs with 10% CSE induced cell death accompanied by activation of caspase. Of the garlic extracts, treatment with ARG extract reduced CSE‐induced cell death. The combination of ARG extract with CSE attenuated the CSE‐induced reduction in glutathione (GSH) content, generation of reactive oxygen species (ROS) and induction of heme oxygenase‐1 expression compared with CSE treatment without ARG extract. Furthermore, the combination of L‐BSO, a GSH synthesis inhibitor, with ARG and CSE extracts failed to increase the intracellular GSH content and cell viability. Taken together, these results demonstrate that ARG extract reduces CSE‐induced cell death by increasing GSH content and reducing ROS generation in HBSMCs.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.3502</identifier><identifier>PMID: 21538625</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Allium ; antioxidant activity ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Biological and medical sciences ; Bronchi - cytology ; Bronchi - drug effects ; Bronchi - metabolism ; bronchiole ; Caspases - metabolism ; cell death ; Cell Death - drug effects ; Cell Line ; cell viability ; garlic ; General pharmacology ; glutathione ; Glutathione - metabolism ; Heme Oxygenase-1 - metabolism ; Humans ; Lung Diseases - etiology ; Lung Diseases - prevention & control ; Medical sciences ; Muscle Cells - drug effects ; Muscle, Smooth - cytology ; Muscle, Smooth - drug effects ; Muscle, Smooth - metabolism ; myocytes ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; reactive oxygen species ; Reactive Oxygen Species - metabolism ; respiratory tract diseases ; smoke ; Smoke - adverse effects ; smoking ; Smoking - adverse effects ; smooth muscle</subject><ispartof>Phytotherapy research, 2012, Vol.26 (1), p.18-25</ispartof><rights>Copyright © 2011 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4122-24bbab7165c5964ff2f1cea725aac46bd1bddd5fa47824dfb56a091f39671d523</citedby><cites>FETCH-LOGICAL-c4122-24bbab7165c5964ff2f1cea725aac46bd1bddd5fa47824dfb56a091f39671d523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.3502$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.3502$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25376976$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21538625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, Yi‐Yeong</creatorcontrib><creatorcontrib>Park, Hye‐Jin</creatorcontrib><creatorcontrib>Cho, Young‐Woo</creatorcontrib><creatorcontrib>Kim, Eun‐Jin</creatorcontrib><creatorcontrib>Kim, Gyu‐Tae</creatorcontrib><creatorcontrib>Mun, Yun‐Ja</creatorcontrib><creatorcontrib>Lee, Jong Deog</creatorcontrib><creatorcontrib>Shin, Jung‐Hye</creatorcontrib><creatorcontrib>Sung, Nak‐Ju</creatorcontrib><creatorcontrib>Kang, Dawon</creatorcontrib><creatorcontrib>Han, Jaehee</creatorcontrib><title>Aged Red Garlic Extract Reduces Cigarette Smoke Extract‐induced Cell Death in Human Bronchial Smooth Muscle Cells by Increasing Intracellular Glutathione Levels</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Increasing antioxidant capacity has been proposed as a promising strategy to prevent cigarette smoke‐induced lung diseases. This study tested whether garlic extracts prevented cigarette smoke extract (CSE)‐induced cell death in human bronchial smooth muscle cells (HBSMCs). Garlic extracts were prepared from fresh raw garlic (FRG), aged black garlic (ABG) and aged red garlic (ARG). Treatment of HBSMCs with 10% CSE induced cell death accompanied by activation of caspase. Of the garlic extracts, treatment with ARG extract reduced CSE‐induced cell death. The combination of ARG extract with CSE attenuated the CSE‐induced reduction in glutathione (GSH) content, generation of reactive oxygen species (ROS) and induction of heme oxygenase‐1 expression compared with CSE treatment without ARG extract. Furthermore, the combination of L‐BSO, a GSH synthesis inhibitor, with ARG and CSE extracts failed to increase the intracellular GSH content and cell viability. Taken together, these results demonstrate that ARG extract reduces CSE‐induced cell death by increasing GSH content and reducing ROS generation in HBSMCs.</description><subject>Allium</subject><subject>antioxidant activity</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bronchi - cytology</subject><subject>Bronchi - drug effects</subject><subject>Bronchi - metabolism</subject><subject>bronchiole</subject><subject>Caspases - metabolism</subject><subject>cell death</subject><subject>Cell Death - drug effects</subject><subject>Cell Line</subject><subject>cell viability</subject><subject>garlic</subject><subject>General pharmacology</subject><subject>glutathione</subject><subject>Glutathione - metabolism</subject><subject>Heme Oxygenase-1 - metabolism</subject><subject>Humans</subject><subject>Lung Diseases - etiology</subject><subject>Lung Diseases - prevention & control</subject><subject>Medical sciences</subject><subject>Muscle Cells - drug effects</subject><subject>Muscle, Smooth - cytology</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - metabolism</subject><subject>myocytes</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>respiratory tract diseases</subject><subject>smoke</subject><subject>Smoke - adverse effects</subject><subject>smoking</subject><subject>Smoking - adverse effects</subject><subject>smooth muscle</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ks1u1DAUhS0EosOAxBOANwg2KbZjJ-NlGUpaMfxo2gp21o3jTE2dZLAT6Ox4BJ6BR-NJcJi0rFhYtu75fO6VjxF6TMkhJYS93Pb-MBWE3UEzSqRMqMjTu2hGpKAJp4vPB-hBCF8IIZIRfh8dMCrSRcbEDP062pgKr-MqwDur8fF170H3Y2nQJuCl3YA3fW_wWdNdmRv994-fth2JCi-Nc_i1gf4S2xafDA20-JXvWn1pwY23uqi8G4J25i8bcLnDp632BoJtN_E4OkZhcOBx4YY-WtmuNXhlvhkXHqJ7NbhgHk37HF28OT5fniSrD8Xp8miVaE4ZSxgvSyhzmgktZMbrmtVUG8iZANA8KytaVlUlauD5gvGqLkUGRNI6lVlOK8HSOXq-99367utgQq8aG8a5oDXdEJSkgnDK49PN0Ys9qX0Xgje12nrbgN8pStQYiIqBqDGQiD6ZTIeyMdUteJNABJ5NAAQNrvbQahv-cSLNM5lnkUv23HfrzO6_DdXH8_XUeOJt6M31LQ_-SmV5mgv16X2hMlKs07dSqJF_uudr6BRsfJzh4owRyuOvoYRKkf4BTcS8vA</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Jeong, Yi‐Yeong</creator><creator>Park, Hye‐Jin</creator><creator>Cho, Young‐Woo</creator><creator>Kim, Eun‐Jin</creator><creator>Kim, Gyu‐Tae</creator><creator>Mun, Yun‐Ja</creator><creator>Lee, Jong Deog</creator><creator>Shin, Jung‐Hye</creator><creator>Sung, Nak‐Ju</creator><creator>Kang, Dawon</creator><creator>Han, Jaehee</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Aged Red Garlic Extract Reduces Cigarette Smoke Extract‐induced Cell Death in Human Bronchial Smooth Muscle Cells by Increasing Intracellular Glutathione Levels</title><author>Jeong, Yi‐Yeong ; Park, Hye‐Jin ; Cho, Young‐Woo ; Kim, Eun‐Jin ; Kim, Gyu‐Tae ; Mun, Yun‐Ja ; Lee, Jong Deog ; Shin, Jung‐Hye ; Sung, Nak‐Ju ; Kang, Dawon ; Han, Jaehee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4122-24bbab7165c5964ff2f1cea725aac46bd1bddd5fa47824dfb56a091f39671d523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Allium</topic><topic>antioxidant activity</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bronchi - cytology</topic><topic>Bronchi - drug effects</topic><topic>Bronchi - metabolism</topic><topic>bronchiole</topic><topic>Caspases - metabolism</topic><topic>cell death</topic><topic>Cell Death - drug effects</topic><topic>Cell Line</topic><topic>cell viability</topic><topic>garlic</topic><topic>General pharmacology</topic><topic>glutathione</topic><topic>Glutathione - metabolism</topic><topic>Heme Oxygenase-1 - metabolism</topic><topic>Humans</topic><topic>Lung Diseases - etiology</topic><topic>Lung Diseases - prevention & control</topic><topic>Medical sciences</topic><topic>Muscle Cells - drug effects</topic><topic>Muscle, Smooth - cytology</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - metabolism</topic><topic>myocytes</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>respiratory tract diseases</topic><topic>smoke</topic><topic>Smoke - adverse effects</topic><topic>smoking</topic><topic>Smoking - adverse effects</topic><topic>smooth muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeong, Yi‐Yeong</creatorcontrib><creatorcontrib>Park, Hye‐Jin</creatorcontrib><creatorcontrib>Cho, Young‐Woo</creatorcontrib><creatorcontrib>Kim, Eun‐Jin</creatorcontrib><creatorcontrib>Kim, Gyu‐Tae</creatorcontrib><creatorcontrib>Mun, Yun‐Ja</creatorcontrib><creatorcontrib>Lee, Jong Deog</creatorcontrib><creatorcontrib>Shin, Jung‐Hye</creatorcontrib><creatorcontrib>Sung, Nak‐Ju</creatorcontrib><creatorcontrib>Kang, Dawon</creatorcontrib><creatorcontrib>Han, Jaehee</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, Yi‐Yeong</au><au>Park, Hye‐Jin</au><au>Cho, Young‐Woo</au><au>Kim, Eun‐Jin</au><au>Kim, Gyu‐Tae</au><au>Mun, Yun‐Ja</au><au>Lee, Jong Deog</au><au>Shin, Jung‐Hye</au><au>Sung, Nak‐Ju</au><au>Kang, Dawon</au><au>Han, Jaehee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aged Red Garlic Extract Reduces Cigarette Smoke Extract‐induced Cell Death in Human Bronchial Smooth Muscle Cells by Increasing Intracellular Glutathione Levels</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2012</date><risdate>2012</risdate><volume>26</volume><issue>1</issue><spage>18</spage><epage>25</epage><pages>18-25</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Increasing antioxidant capacity has been proposed as a promising strategy to prevent cigarette smoke‐induced lung diseases. This study tested whether garlic extracts prevented cigarette smoke extract (CSE)‐induced cell death in human bronchial smooth muscle cells (HBSMCs). Garlic extracts were prepared from fresh raw garlic (FRG), aged black garlic (ABG) and aged red garlic (ARG). Treatment of HBSMCs with 10% CSE induced cell death accompanied by activation of caspase. Of the garlic extracts, treatment with ARG extract reduced CSE‐induced cell death. The combination of ARG extract with CSE attenuated the CSE‐induced reduction in glutathione (GSH) content, generation of reactive oxygen species (ROS) and induction of heme oxygenase‐1 expression compared with CSE treatment without ARG extract. Furthermore, the combination of L‐BSO, a GSH synthesis inhibitor, with ARG and CSE extracts failed to increase the intracellular GSH content and cell viability. Taken together, these results demonstrate that ARG extract reduces CSE‐induced cell death by increasing GSH content and reducing ROS generation in HBSMCs.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>21538625</pmid><doi>10.1002/ptr.3502</doi><tpages>8</tpages></addata></record> |
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| subjects | Allium antioxidant activity Antioxidants - pharmacology Antioxidants - therapeutic use Biological and medical sciences Bronchi - cytology Bronchi - drug effects Bronchi - metabolism bronchiole Caspases - metabolism cell death Cell Death - drug effects Cell Line cell viability garlic General pharmacology glutathione Glutathione - metabolism Heme Oxygenase-1 - metabolism Humans Lung Diseases - etiology Lung Diseases - prevention & control Medical sciences Muscle Cells - drug effects Muscle, Smooth - cytology Muscle, Smooth - drug effects Muscle, Smooth - metabolism myocytes Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use reactive oxygen species Reactive Oxygen Species - metabolism respiratory tract diseases smoke Smoke - adverse effects smoking Smoking - adverse effects smooth muscle |
| title | Aged Red Garlic Extract Reduces Cigarette Smoke Extract‐induced Cell Death in Human Bronchial Smooth Muscle Cells by Increasing Intracellular Glutathione Levels |
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