Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial

Summary Background Studies with pertuzumab, a novel anti-HER2 antibody, show improved efficacy when combined with the established HER2-directed antibody trastuzumab in breast cancer therapy. We investigated the combination of pertuzumab or trastuzumab, or both, with docetaxel and the combination of...

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Veröffentlicht in:	The lancet oncology 2012, Vol.13 (1), p.25-32
Hauptverfasser:	Gianni, Luca, Dr, Pienkowski, Tadeusz, Prof, Im, Young-Hyuck, Prof, Roman, Laslo, MD, Tseng, Ling-Ming, MD, Liu, Mei-Ching, MD, Lluch, Ana, MD, Staroslawska, Elżbieta, Prof, de la Haba-Rodriguez, Juan, MD, Im, Seock-Ah, Prof, Pedrini, Jose Luiz, MD, Poirier, Brigitte, MD, Morandi, Paolo, MD, Semiglazov, Vladimir, Prof, Srimuninnimit, Vichien, Prof, Bianchi, Giulia, MD, Szado, Tania, PhD, Ratnayake, Jayantha, BSc, Ross, Graham, MD, Valagussa, Pinuccia, BS
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Asia Biomarkers, Tumor - antagonists & inhibitors Biomarkers, Tumor - metabolism Brazil Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - pathology Breast Neoplasms - surgery Canada Cancer therapies Chemotherapy Chemotherapy, Adjuvant Drug dosages Europe Female Hematology, Oncology and Palliative Medicine Humans Inflammation - pathology Ligands Mastectomy Medical prognosis Metastasis Middle Aged Monoclonal antibodies Neoadjuvant Therapy Neoplasm Invasiveness Neutropenia Protein Kinase Inhibitors - administration & dosage Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - metabolism Response rates Surgery Taxoids - administration & dosage Time Factors Trastuzumab Treatment Outcome Tumors Womens health Young Adult
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