Novel Effect of Adenosine 5′-Monophosphate on Ameliorating Hypertension and the Metabolism of Lipids and Glucose in Stroke-Prone Spontaneously Hypertensive Rats
The aim of the study was to investigate the effects of adenosine 5′-monophosphate (AMP) in stroke-prone spontaneously hypertensive rats (SHRSP). Male rats (10 weeks old) were divided into three groups: a control group fed an AIN-93 M diet and two others fed supplemental AMP (17.5 and 87.5 mg/kg diet...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2011-12, Vol.59 (24), p.13238-13245 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Ardiansyah Shirakawa, Hitoshi Koseki, Takuya Hiwatashi, Kazuyuki Takahasi, Saori Akiyama, Yoshinobu Komai, Michio |
| description | The aim of the study was to investigate the effects of adenosine 5′-monophosphate (AMP) in stroke-prone spontaneously hypertensive rats (SHRSP). Male rats (10 weeks old) were divided into three groups: a control group fed an AIN-93 M diet and two others fed supplemental AMP (17.5 and 87.5 mg/kg diet) for 3 weeks. AMP effectively improved hypertension, plasma triglyceride, and HDL-cholesterol, glucose, kidney function parameters, hepatic lipid, enhances plasma nitric oxide, and plasma adiponectin accompanied by the up-regulation of mRNA expression levels of the hepatic adiponectin receptor 2. Single and chronic oral administration of AMP affected the hepatic mRNA expression levels of genes involved in β-oxidation, fatty acid synthesis, and AMP-activated protein kinase. Furthermore, a single oral dose of AMP (40 mg/kg body weight) improved hypertension and hyperglycemia in SHRSP. In conclusion, AMP displays a novel effect in ameliorating metabolic-related diseases in SHRSP and could be beneficial as a functional food. |
| doi_str_mv | 10.1021/jf203237c |
| format | Article |
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Male rats (10 weeks old) were divided into three groups: a control group fed an AIN-93 M diet and two others fed supplemental AMP (17.5 and 87.5 mg/kg diet) for 3 weeks. AMP effectively improved hypertension, plasma triglyceride, and HDL-cholesterol, glucose, kidney function parameters, hepatic lipid, enhances plasma nitric oxide, and plasma adiponectin accompanied by the up-regulation of mRNA expression levels of the hepatic adiponectin receptor 2. Single and chronic oral administration of AMP affected the hepatic mRNA expression levels of genes involved in β-oxidation, fatty acid synthesis, and AMP-activated protein kinase. Furthermore, a single oral dose of AMP (40 mg/kg body weight) improved hypertension and hyperglycemia in SHRSP. In conclusion, AMP displays a novel effect in ameliorating metabolic-related diseases in SHRSP and could be beneficial as a functional food.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf203237c</identifier><identifier>PMID: 22103713</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>adenosine ; adenosine monophosphate ; Adenosine Monophosphate - administration & dosage ; adiponectin ; AMP-activated protein kinase ; Animals ; beta oxidation ; Biological and medical sciences ; Blood Glucose - analysis ; body weight ; Cholesterol, HDL - blood ; Diet ; fatty acids ; Food industries ; functional foods ; Fundamental and applied biological sciences. Psychology ; gene expression ; glucose ; Hyperglycemia - drug therapy ; Hyperlipidemias - drug therapy ; hypertension ; Hypertension - drug therapy ; Liver - chemistry ; Male ; messenger RNA ; nitric oxide ; Nitric Oxide - blood ; oral administration ; Rats ; Rats, Inbred SHR ; renal function ; RNA, Messenger - analysis ; Stroke ; Triglycerides - blood</subject><ispartof>Journal of agricultural and food chemistry, 2011-12, Vol.59 (24), p.13238-13245</ispartof><rights>Copyright © 2011 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a364t-8b6b54a68186f730e6fc9baf546d2a7f8e0829416f90bf3151070316704346033</citedby><cites>FETCH-LOGICAL-a364t-8b6b54a68186f730e6fc9baf546d2a7f8e0829416f90bf3151070316704346033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf203237c$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf203237c$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,781,785,2766,27081,27929,27930,56743,56793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25344191$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22103713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ardiansyah</creatorcontrib><creatorcontrib>Shirakawa, Hitoshi</creatorcontrib><creatorcontrib>Koseki, Takuya</creatorcontrib><creatorcontrib>Hiwatashi, Kazuyuki</creatorcontrib><creatorcontrib>Takahasi, Saori</creatorcontrib><creatorcontrib>Akiyama, Yoshinobu</creatorcontrib><creatorcontrib>Komai, Michio</creatorcontrib><title>Novel Effect of Adenosine 5′-Monophosphate on Ameliorating Hypertension and the Metabolism of Lipids and Glucose in Stroke-Prone Spontaneously Hypertensive Rats</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>The aim of the study was to investigate the effects of adenosine 5′-monophosphate (AMP) in stroke-prone spontaneously hypertensive rats (SHRSP). Male rats (10 weeks old) were divided into three groups: a control group fed an AIN-93 M diet and two others fed supplemental AMP (17.5 and 87.5 mg/kg diet) for 3 weeks. AMP effectively improved hypertension, plasma triglyceride, and HDL-cholesterol, glucose, kidney function parameters, hepatic lipid, enhances plasma nitric oxide, and plasma adiponectin accompanied by the up-regulation of mRNA expression levels of the hepatic adiponectin receptor 2. Single and chronic oral administration of AMP affected the hepatic mRNA expression levels of genes involved in β-oxidation, fatty acid synthesis, and AMP-activated protein kinase. Furthermore, a single oral dose of AMP (40 mg/kg body weight) improved hypertension and hyperglycemia in SHRSP. In conclusion, AMP displays a novel effect in ameliorating metabolic-related diseases in SHRSP and could be beneficial as a functional food.</description><subject>adenosine</subject><subject>adenosine monophosphate</subject><subject>Adenosine Monophosphate - administration & dosage</subject><subject>adiponectin</subject><subject>AMP-activated protein kinase</subject><subject>Animals</subject><subject>beta oxidation</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>body weight</subject><subject>Cholesterol, HDL - blood</subject><subject>Diet</subject><subject>fatty acids</subject><subject>Food industries</subject><subject>functional foods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gene expression</subject><subject>glucose</subject><subject>Hyperglycemia - drug therapy</subject><subject>Hyperlipidemias - drug therapy</subject><subject>hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Liver - chemistry</subject><subject>Male</subject><subject>messenger RNA</subject><subject>nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>oral administration</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>renal function</subject><subject>RNA, Messenger - analysis</subject><subject>Stroke</subject><subject>Triglycerides - blood</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc9u00AQhy0EoqFw4AVgLwhxMMx4_9g-RlVpkVJAhJ6ttT3bbHB23d1Npdx4Fh6BR-JJcEloOXCaw-_TN6P5ZdlzhLcIBb5bmwJ4wcvuQTZDWUAuEauH2QymMK-kwqPsSYxrAKhkCY-zo6JA4CXyWfbjo7-hgZ0aQ11i3rB5T85H64jJX99_5hfe-XHl47jSiZh3bL6hwfqgk3VX7Hw3Ukjkop0S7XqWVsQuKOnWDzZubn0LO9o-_gnPhm3nIzHr2DIF_43yz8FPi5ajd0k78ts47P5x3hD7olN8mj0yeoj07DCPs8v3p19PzvPFp7MPJ_NFrrkSKa9a1UqhVYWVMiUHUqarW22kUH2hS1MRVEUtUJkaWsNRIpTAUZUguFDA-XH2eu8dg7_eUkzNxsaOhmF_WlOjBAGqKibyzZ7sgo8xkGnGYDc67BqE5raR5q6RiX1xsG7bDfV35N8KJuDVAdCx04MJ2nU23nOSC4E1TtzLPWe0b_RVmJjLZQEoABBFWct7k-5is_bb4KZ3_eek36UYqkE</recordid><startdate>20111228</startdate><enddate>20111228</enddate><creator>Ardiansyah</creator><creator>Shirakawa, Hitoshi</creator><creator>Koseki, Takuya</creator><creator>Hiwatashi, Kazuyuki</creator><creator>Takahasi, Saori</creator><creator>Akiyama, Yoshinobu</creator><creator>Komai, Michio</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111228</creationdate><title>Novel Effect of Adenosine 5′-Monophosphate on Ameliorating Hypertension and the Metabolism of Lipids and Glucose in Stroke-Prone Spontaneously Hypertensive Rats</title><author>Ardiansyah ; Shirakawa, Hitoshi ; Koseki, Takuya ; Hiwatashi, Kazuyuki ; Takahasi, Saori ; Akiyama, Yoshinobu ; Komai, Michio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a364t-8b6b54a68186f730e6fc9baf546d2a7f8e0829416f90bf3151070316704346033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>adenosine</topic><topic>adenosine monophosphate</topic><topic>Adenosine Monophosphate - administration & dosage</topic><topic>adiponectin</topic><topic>AMP-activated protein kinase</topic><topic>Animals</topic><topic>beta oxidation</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>body weight</topic><topic>Cholesterol, HDL - blood</topic><topic>Diet</topic><topic>fatty acids</topic><topic>Food industries</topic><topic>functional foods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gene expression</topic><topic>glucose</topic><topic>Hyperglycemia - drug therapy</topic><topic>Hyperlipidemias - drug therapy</topic><topic>hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Liver - chemistry</topic><topic>Male</topic><topic>messenger RNA</topic><topic>nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>oral administration</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>renal function</topic><topic>RNA, Messenger - analysis</topic><topic>Stroke</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ardiansyah</creatorcontrib><creatorcontrib>Shirakawa, Hitoshi</creatorcontrib><creatorcontrib>Koseki, Takuya</creatorcontrib><creatorcontrib>Hiwatashi, Kazuyuki</creatorcontrib><creatorcontrib>Takahasi, Saori</creatorcontrib><creatorcontrib>Akiyama, Yoshinobu</creatorcontrib><creatorcontrib>Komai, Michio</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ardiansyah</au><au>Shirakawa, Hitoshi</au><au>Koseki, Takuya</au><au>Hiwatashi, Kazuyuki</au><au>Takahasi, Saori</au><au>Akiyama, Yoshinobu</au><au>Komai, Michio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel Effect of Adenosine 5′-Monophosphate on Ameliorating Hypertension and the Metabolism of Lipids and Glucose in Stroke-Prone Spontaneously Hypertensive Rats</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2011-12-28</date><risdate>2011</risdate><volume>59</volume><issue>24</issue><spage>13238</spage><epage>13245</epage><pages>13238-13245</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>The aim of the study was to investigate the effects of adenosine 5′-monophosphate (AMP) in stroke-prone spontaneously hypertensive rats (SHRSP). Male rats (10 weeks old) were divided into three groups: a control group fed an AIN-93 M diet and two others fed supplemental AMP (17.5 and 87.5 mg/kg diet) for 3 weeks. AMP effectively improved hypertension, plasma triglyceride, and HDL-cholesterol, glucose, kidney function parameters, hepatic lipid, enhances plasma nitric oxide, and plasma adiponectin accompanied by the up-regulation of mRNA expression levels of the hepatic adiponectin receptor 2. Single and chronic oral administration of AMP affected the hepatic mRNA expression levels of genes involved in β-oxidation, fatty acid synthesis, and AMP-activated protein kinase. Furthermore, a single oral dose of AMP (40 mg/kg body weight) improved hypertension and hyperglycemia in SHRSP. In conclusion, AMP displays a novel effect in ameliorating metabolic-related diseases in SHRSP and could be beneficial as a functional food.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>22103713</pmid><doi>10.1021/jf203237c</doi><tpages>8</tpages></addata></record> |
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| subjects | adenosine adenosine monophosphate Adenosine Monophosphate - administration & dosage adiponectin AMP-activated protein kinase Animals beta oxidation Biological and medical sciences Blood Glucose - analysis body weight Cholesterol, HDL - blood Diet fatty acids Food industries functional foods Fundamental and applied biological sciences. Psychology gene expression glucose Hyperglycemia - drug therapy Hyperlipidemias - drug therapy hypertension Hypertension - drug therapy Liver - chemistry Male messenger RNA nitric oxide Nitric Oxide - blood oral administration Rats Rats, Inbred SHR renal function RNA, Messenger - analysis Stroke Triglycerides - blood |
| title | Novel Effect of Adenosine 5′-Monophosphate on Ameliorating Hypertension and the Metabolism of Lipids and Glucose in Stroke-Prone Spontaneously Hypertensive Rats |
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