Dual energy computed tomography for quantification of tissue urate deposits in tophaceous gout: help from modern physics in the management of an ancient disease
Gout has been recognized for centuries but is also a modern day scourge. It is the most common type of inflammatory arthritis in men and appears to be increasing in both incidence and prevalence (Arromdee et al. in J Rheumatol 29(11):2403–2406, 2002). Despite these facts, few advances have been made...
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| Veröffentlicht in: | Rheumatology international 2012, Vol.32 (1), p.235-239 |
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| creator | Bacani, A. Kirstin McCollough, Cynthia H. Glazebrook, Katrina N. Bond, Jeffrey R. Michet, Clement J. Milks, Jeffrey Manek, Nisha J. |
| description | Gout has been recognized for centuries but is also a modern day scourge. It is the most common type of inflammatory arthritis in men and appears to be increasing in both incidence and prevalence (Arromdee et al. in J Rheumatol 29(11):2403–2406, 2002). Despite these facts, few advances have been made in the diagnosis and treatment of gout for over 50 years. Difficult cases of gout challenge available therapeutic options. It is only recently that the Food and Drug Administration has approved febuxostat as a treatment option for patients intolerant of allopurinol. We describe a difficult case of tophaceous gout notable for several reasons: utilization of rasburicase as uricolytic treatment to dramatically reduce tissue urate burden; treatment of gout flares with interleukin-1β inhibition; and quantification of tissue urate with novel dual energy computed tomography technology before and after uricolytic therapy. |
| doi_str_mv | 10.1007/s00296-009-1295-7 |
| format | Article |
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We describe a difficult case of tophaceous gout notable for several reasons: utilization of rasburicase as uricolytic treatment to dramatically reduce tissue urate burden; treatment of gout flares with interleukin-1β inhibition; and quantification of tissue urate with novel dual energy computed tomography technology before and after uricolytic therapy.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-009-1295-7</identifier><identifier>PMID: 20016988</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Case Report ; Gout - diagnostic imaging ; Gout - drug therapy ; Gout - metabolism ; Gout Suppressants - pharmacology ; Gout Suppressants - therapeutic use ; Hand Joints - diagnostic imaging ; Hand Joints - drug effects ; Hand Joints - metabolism ; Humans ; Interleukin 1 Receptor Antagonist Protein - pharmacology ; Interleukin 1 Receptor Antagonist Protein - therapeutic use ; Interleukin-1beta - antagonists & inhibitors ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Rheumatology ; Tomography, X-Ray Computed - methods ; Treatment Outcome ; Urate Oxidase - pharmacology ; Urate Oxidase - therapeutic use ; Uric Acid - metabolism ; Wrist Joint - diagnostic imaging ; Wrist Joint - drug effects ; Wrist Joint - metabolism</subject><ispartof>Rheumatology international, 2012, Vol.32 (1), p.235-239</ispartof><rights>Springer-Verlag 2009</rights><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-105930f9f8a3b3fd23e6259226ba9ff48a6cb6caf9ee382b5879c66ef41d5c573</citedby><cites>FETCH-LOGICAL-c370t-105930f9f8a3b3fd23e6259226ba9ff48a6cb6caf9ee382b5879c66ef41d5c573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00296-009-1295-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00296-009-1295-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20016988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bacani, A. 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| fulltext | fulltext |
| identifier | ISSN: 0172-8172 |
| ispartof | Rheumatology international, 2012, Vol.32 (1), p.235-239 |
| issn | 0172-8172 1437-160X |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Case Report Gout - diagnostic imaging Gout - drug therapy Gout - metabolism Gout Suppressants - pharmacology Gout Suppressants - therapeutic use Hand Joints - diagnostic imaging Hand Joints - drug effects Hand Joints - metabolism Humans Interleukin 1 Receptor Antagonist Protein - pharmacology Interleukin 1 Receptor Antagonist Protein - therapeutic use Interleukin-1beta - antagonists & inhibitors Male Medicine Medicine & Public Health Middle Aged Rheumatology Tomography, X-Ray Computed - methods Treatment Outcome Urate Oxidase - pharmacology Urate Oxidase - therapeutic use Uric Acid - metabolism Wrist Joint - diagnostic imaging Wrist Joint - drug effects Wrist Joint - metabolism |
| title | Dual energy computed tomography for quantification of tissue urate deposits in tophaceous gout: help from modern physics in the management of an ancient disease |
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