Facile Synthesis, Antioxidant and Antimicrobial Activity of Amino Methylene Bisphosphonates

A green and efficient preparation method for the amino bisphosphonates is accomplished by simple mixing and stirring of diethylphosphite, triethylorthoformate and various amines in the presence of amberlyst-15 as catalyst at room temperature under solvent free conditions. The title compounds are cha...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2012/01/01, Vol.60(1), pp.104-109
Hauptverfasser:	Kunda, Uma Maheswara Rao, Balam, Satheesh Krishna, Nemallapudi, Bakthavatchala Reddy, Chereddy, Syama Sundar, Nayak, Sandip Kumar, Cirandur, Suresh Reddy
Format:	Artikel
Sprache:	eng
Schlagworte:	amberlyst-15 Amines - chemistry amino methylene bisphosphonate Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology antimicrobial activity antioxidant activity Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Bacteria - drug effects Catalysis Diphosphonates - chemical synthesis Diphosphonates - chemistry Diphosphonates - pharmacology Formates - chemistry Fungi - drug effects Microbial Sensitivity Tests Phosphites - chemistry Styrenes - chemistry Temperature
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Zusammenfassung:	A green and efficient preparation method for the amino bisphosphonates is accomplished by simple mixing and stirring of diethylphosphite, triethylorthoformate and various amines in the presence of amberlyst-15 as catalyst at room temperature under solvent free conditions. The title compounds are characterized by IR, 1H-, 13C-, 31P-NMR and mass spectra, also studied their antimicrobial and antioxidant activity.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.60.104