A 5% Glucose Infusion Fluid Provokes Significant Precipitation of Phenytoin Sodium Injection via Interruption of the Cosolvent Effect of Propylene Glycol

The precipitation of phenytoin sodium injection provoked by mixing with infusion fluids renders its use in clinical practice difficult, as rapid intravenous (i.v.) push and i.v. infusion are supposed to be avoided. As some of its aspects remain unclear, this study tried to elucidate this precipitati...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2012/01/01, Vol.60(1), pp.86-93
Hauptverfasser:	Onuki, Yoshinori, Ikegami-Kawai, Mayumi, Ishitsuka, Kazumi, Hayashi, Yoshihiro, Takayama, Kozo
Format:	Artikel
Sprache:	eng
Schlagworte:	2-dimensional nuclear Overhauser effect spectroscopy Crystallization Glucose - chemistry glucose infusion fluid Humans Hydrogen-Ion Concentration Injections, Intravenous Magnetic Resonance Spectroscopy phenytoin Phenytoin - chemistry precipitation propylene glycol Propylene Glycol - chemistry Solubility Solvents - chemistry
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