Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors

Recent genome wide association studies have identified susceptibility loci for adult testicular germ cell tumors (GCT) near KITLG, SPRY4, BAK1, and DMRT1. We evaluated variants in these four genes to determine whether these are also susceptibility loci for pediatric GCTs. DNA was isolated from 52 pe...

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Veröffentlicht in:	Genes chromosomes & cancer 2012-03, Vol.51 (3), p.266-271
Hauptverfasser:	Poynter, Jenny N., Hooten, Anthony J., Lindsay Frazier, A., Ross, Julie A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Factors bcl-2 Homologous Antagonist-Killer Protein - genetics Child Child, Preschool Endodermal Sinus Tumor - genetics Female Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Infant, Newborn Intracellular Signaling Peptides and Proteins - genetics Male Molecular Typing Neoplasms, Germ Cell and Embryonal - genetics Nerve Tissue Proteins - genetics Phenotype Polymerase Chain Reaction Polymorphism, Single Nucleotide Sex Factors Stem Cell Factor - genetics Teratoma - genetics Testicular Neoplasms - genetics Transcription Factors - genetics Young Adult
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