The expression of interleukin-1 alpha, TNF and VEGF in corneal cells of patients with bullous keratopathy
Bullous keratopathy (BK) is a chronic corneal edema with or without subepithelial bullae as a result of a loss of the endothelial cells. 15 patients with BK after cataract surgery with intraocular lens implantation, due to Fuchs dystrophy (n = 3) or corneal endothelial trauma (n = 12) were included...
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| Veröffentlicht in: | Collegium antropologicum 2011-09, Vol.35 Suppl 2 (Supp. 2), p.171-174 |
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| container_issue | Supp. 2 |
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| container_title | Collegium antropologicum |
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| creator | Grzetić-Lenac, Renata Merlak, Maja Balog, Tihomir Markusić, Vedran Dekaris, Iva |
| description | Bullous keratopathy (BK) is a chronic corneal edema with or without subepithelial bullae as a result of a loss of the endothelial cells. 15 patients with BK after cataract surgery with intraocular lens implantation, due to Fuchs dystrophy (n = 3) or corneal endothelial trauma (n = 12) were included in the study. All patients were treated by amniotic membrane transplantation (AMT). Corneal epithelial cells in patients suffering from BK secreted 3.91 +/- 3.09 pg/mL of IL-1 alpha, 4446 +/- 16.8 pg/mL of TNF and 81.43 +/- 37.81 pg/mL of VEGF-I. Levels of all 3 investigated cytokines were significantly higher as compared to controls (p < 0.005). Amniotic membranes that were used to treat investigated patients contained 638.98 +/- 613.98 pg/mL of IL-1ra, 0.026 +/- 0.009 pg/mL of sTNF and 81.39 +/- 21.01 pg/mL of VEGF-R. Beneficial clinical effect of the AMT in treating BK could be explained by its natural production of pro-inflammatory cytokine antagonists such as IL-ra, sTNF antagonist and VEGF-R. |
| format | Article |
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All patients were treated by amniotic membrane transplantation (AMT). Corneal epithelial cells in patients suffering from BK secreted 3.91 +/- 3.09 pg/mL of IL-1 alpha, 4446 +/- 16.8 pg/mL of TNF and 81.43 +/- 37.81 pg/mL of VEGF-I. Levels of all 3 investigated cytokines were significantly higher as compared to controls (p < 0.005). Amniotic membranes that were used to treat investigated patients contained 638.98 +/- 613.98 pg/mL of IL-1ra, 0.026 +/- 0.009 pg/mL of sTNF and 81.39 +/- 21.01 pg/mL of VEGF-R. 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All patients were treated by amniotic membrane transplantation (AMT). Corneal epithelial cells in patients suffering from BK secreted 3.91 +/- 3.09 pg/mL of IL-1 alpha, 4446 +/- 16.8 pg/mL of TNF and 81.43 +/- 37.81 pg/mL of VEGF-I. Levels of all 3 investigated cytokines were significantly higher as compared to controls (p < 0.005). Amniotic membranes that were used to treat investigated patients contained 638.98 +/- 613.98 pg/mL of IL-1ra, 0.026 +/- 0.009 pg/mL of sTNF and 81.39 +/- 21.01 pg/mL of VEGF-R. Beneficial clinical effect of the AMT in treating BK could be explained by its natural production of pro-inflammatory cytokine antagonists such as IL-ra, sTNF antagonist and VEGF-R.</description><subject>Amnion - immunology</subject><subject>Amnion - metabolism</subject><subject>Amnion - transplantation</subject><subject>Blindness</subject><subject>Cornea - immunology</subject><subject>Cornea - metabolism</subject><subject>Cornea - surgery</subject><subject>Corneal Edema - immunology</subject><subject>Corneal Edema - surgery</subject><subject>Fuchs' Endothelial Dystrophy - immunology</subject><subject>Fuchs' Endothelial Dystrophy - surgery</subject><subject>Graft Survival - immunology</subject><subject>Humans</subject><subject>Interleukin-1alpha - immunology</subject><subject>Interleukin-1alpha - metabolism</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Receptors, Vascular Endothelial Growth Factor - immunology</subject><subject>Receptors, Vascular Endothelial Growth Factor - metabolism</subject><subject>Sight</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0350-6134</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDFPwzAUhD2AaCn8BeQNBiI5sWPHI6raglTBUlgj23lRTF0n2I6g_54gyspbbnjfnU53huaEliTjOWUzdBnjOyGl4IRfoFkxHWFFNUd21wGGryFAjLb3uG-x9QmCg3FvfZZj5YZO3ePd8xor3-C31WY9Edj0wYNy2IBz8cc1qGTBp4g_beqwHp3rx4j3EFTqp193vELnrXIRrk-6QK_r1W75mG1fNk_Lh2025IKmjLZGl7LQrGil4BWtuKpMq4XRRUWV4A1oKUXVCFlCTlsKRjDJlKGNLkoFnC7Q7W_uEPqPEWKqDzb-1FQepkq1zBnnXAgykXf_kjkjpCoonxZcoJsTOuoDNPUQ7EGFY_03JP0GSsFuGg</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Grzetić-Lenac, Renata</creator><creator>Merlak, Maja</creator><creator>Balog, Tihomir</creator><creator>Markusić, Vedran</creator><creator>Dekaris, Iva</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>The expression of interleukin-1 alpha, TNF and VEGF in corneal cells of patients with bullous keratopathy</title><author>Grzetić-Lenac, Renata ; 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All patients were treated by amniotic membrane transplantation (AMT). Corneal epithelial cells in patients suffering from BK secreted 3.91 +/- 3.09 pg/mL of IL-1 alpha, 4446 +/- 16.8 pg/mL of TNF and 81.43 +/- 37.81 pg/mL of VEGF-I. Levels of all 3 investigated cytokines were significantly higher as compared to controls (p < 0.005). Amniotic membranes that were used to treat investigated patients contained 638.98 +/- 613.98 pg/mL of IL-1ra, 0.026 +/- 0.009 pg/mL of sTNF and 81.39 +/- 21.01 pg/mL of VEGF-R. Beneficial clinical effect of the AMT in treating BK could be explained by its natural production of pro-inflammatory cytokine antagonists such as IL-ra, sTNF antagonist and VEGF-R.</abstract><cop>Croatia</cop><pmid>22220428</pmid><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Amnion - immunology Amnion - metabolism Amnion - transplantation Blindness Cornea - immunology Cornea - metabolism Cornea - surgery Corneal Edema - immunology Corneal Edema - surgery Fuchs' Endothelial Dystrophy - immunology Fuchs' Endothelial Dystrophy - surgery Graft Survival - immunology Humans Interleukin-1alpha - immunology Interleukin-1alpha - metabolism Medical treatment Medicine Patients Prospective Studies Receptors, Vascular Endothelial Growth Factor - immunology Receptors, Vascular Endothelial Growth Factor - metabolism Sight Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism |
| title | The expression of interleukin-1 alpha, TNF and VEGF in corneal cells of patients with bullous keratopathy |
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