Transplantation of amniotic membrane in corneal ulcers and persistant epithelial defects
Amniotic membrane transplantation (AMT) leads to reduction of inflammatory symptoms and causes faster epithelisation in corneal ulcers and persistant epithelial defect. 21 patients with corneal ulcer (n = 18) or non-healing epithelial defect (n = 3) unresponsive to conventional treatment were includ...
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| Veröffentlicht in: | Collegium antropologicum 2011-09, Vol.35 Suppl 2 (Supp. 2), p.167-170 |
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| container_end_page | 170 |
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| container_issue | Supp. 2 |
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| container_title | Collegium antropologicum |
| container_volume | 35 Suppl 2 |
| creator | Grzetić-Lenac, Renata Merlak, Maja Balog, Tihomir Babić, Marijana Bilen Dekaris, Iva |
| description | Amniotic membrane transplantation (AMT) leads to reduction of inflammatory symptoms and causes faster epithelisation in corneal ulcers and persistant epithelial defect. 21 patients with corneal ulcer (n = 18) or non-healing epithelial defect (n = 3) unresponsive to conventional treatment were included in the study. All patients were treated by AMT. Corneal epithelial cells in patients suffering from corneal ulcer secreted 3.51 +/- 1.79 of IL-1alpha, 64.27 +/- 31.53 pg/mL of TNFalpha and 209.07 +/- 201.82 pg/mL of VEGF. Levels of all 3 investigated cytokines were significantly higher as compared to controls (p < 0.005). Amniotic membranes that were used contained 775.69 +/- 613.98 pg/mL of IL-1alpha, 0.036 +/- 0.033 pg/mL of sTNF and 175.01 +/- 166.63 pg/mL of VEGF-R. Supporting effect of the AMT could be explained by the fact that AM secretes its natural antinflammatory antagonists IL-1ra, sTNF and VEGF-R. |
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All patients were treated by AMT. Corneal epithelial cells in patients suffering from corneal ulcer secreted 3.51 +/- 1.79 of IL-1alpha, 64.27 +/- 31.53 pg/mL of TNFalpha and 209.07 +/- 201.82 pg/mL of VEGF. Levels of all 3 investigated cytokines were significantly higher as compared to controls (p < 0.005). Amniotic membranes that were used contained 775.69 +/- 613.98 pg/mL of IL-1alpha, 0.036 +/- 0.033 pg/mL of sTNF and 175.01 +/- 166.63 pg/mL of VEGF-R. 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All patients were treated by AMT. Corneal epithelial cells in patients suffering from corneal ulcer secreted 3.51 +/- 1.79 of IL-1alpha, 64.27 +/- 31.53 pg/mL of TNFalpha and 209.07 +/- 201.82 pg/mL of VEGF. Levels of all 3 investigated cytokines were significantly higher as compared to controls (p < 0.005). Amniotic membranes that were used contained 775.69 +/- 613.98 pg/mL of IL-1alpha, 0.036 +/- 0.033 pg/mL of sTNF and 175.01 +/- 166.63 pg/mL of VEGF-R. Supporting effect of the AMT could be explained by the fact that AM secretes its natural antinflammatory antagonists IL-1ra, sTNF and VEGF-R.</description><subject>Amnion - immunology</subject><subject>Amnion - secretion</subject><subject>Amnion - transplantation</subject><subject>Blindness</subject><subject>Corneal Ulcer - immunology</subject><subject>Corneal Ulcer - surgery</subject><subject>Graft Survival - immunology</subject><subject>Humans</subject><subject>Interleukin 1 Receptor Antagonist Protein - immunology</subject><subject>Interleukin 1 Receptor Antagonist Protein - secretion</subject><subject>Keratitis - immunology</subject><subject>Keratitis - surgery</subject><subject>Medical treatment</subject><subject>Pharmaceuticals</subject><subject>Prospective Studies</subject><subject>Receptors, Vascular Endothelial Growth Factor - immunology</subject><subject>Receptors, Vascular Endothelial Growth Factor - secretion</subject><subject>Sight</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Tumor Necrosis Factor-alpha - secretion</subject><issn>0350-6134</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90EtLxDAQAOAcFHdd_QuSm14KaR6T9CiLL1jwsoK3kiZTjLRpbdKD_96A69W5zMB8MzBzRrZMKFZBLeSGXKb0yZjSwOCCbHgJJrnekvfjYmOaBxuzzWGKdOqpHWOYcnB0xLErbaQhUjctEe1A18HhkqiNns6lCCmXUYpzyB84hAI89uhyuiLnvR0SXp_yjrw9Phz3z9Xh9ellf3-o5lqLXClgxjgplVXeW92brvESOo3eGSONA4m2Nl4zZQGBSy6U1FJIyRlnnlmxI7e_e-dl-lox5XYMyeFQLsJpTW1TSwDQ0BR596-sJWOGCwBe6M2Jrt2Ivp2XMNrlu_37m_gBcwxoaw</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Grzetić-Lenac, Renata</creator><creator>Merlak, Maja</creator><creator>Balog, Tihomir</creator><creator>Babić, Marijana Bilen</creator><creator>Dekaris, Iva</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>Transplantation of amniotic membrane in corneal ulcers and persistant epithelial defects</title><author>Grzetić-Lenac, Renata ; Merlak, Maja ; Balog, Tihomir ; Babić, Marijana Bilen ; Dekaris, Iva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p173t-56088c445a5dda7f8b9d46b7edc8848c64ea18d705a6e6242354743442020d0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Amnion - immunology</topic><topic>Amnion - secretion</topic><topic>Amnion - transplantation</topic><topic>Blindness</topic><topic>Corneal Ulcer - immunology</topic><topic>Corneal Ulcer - surgery</topic><topic>Graft Survival - immunology</topic><topic>Humans</topic><topic>Interleukin 1 Receptor Antagonist Protein - immunology</topic><topic>Interleukin 1 Receptor Antagonist Protein - secretion</topic><topic>Keratitis - immunology</topic><topic>Keratitis - surgery</topic><topic>Medical treatment</topic><topic>Pharmaceuticals</topic><topic>Prospective Studies</topic><topic>Receptors, Vascular Endothelial Growth Factor - immunology</topic><topic>Receptors, Vascular Endothelial Growth Factor - secretion</topic><topic>Sight</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><topic>Tumor Necrosis Factor-alpha - secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grzetić-Lenac, Renata</creatorcontrib><creatorcontrib>Merlak, Maja</creatorcontrib><creatorcontrib>Balog, Tihomir</creatorcontrib><creatorcontrib>Babić, Marijana Bilen</creatorcontrib><creatorcontrib>Dekaris, Iva</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>MEDLINE - Academic</collection><jtitle>Collegium antropologicum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grzetić-Lenac, Renata</au><au>Merlak, Maja</au><au>Balog, Tihomir</au><au>Babić, Marijana Bilen</au><au>Dekaris, Iva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transplantation of amniotic membrane in corneal ulcers and persistant epithelial defects</atitle><jtitle>Collegium antropologicum</jtitle><addtitle>Coll Antropol</addtitle><date>2011-09</date><risdate>2011</risdate><volume>35 Suppl 2</volume><issue>Supp. 2</issue><spage>167</spage><epage>170</epage><pages>167-170</pages><issn>0350-6134</issn><abstract>Amniotic membrane transplantation (AMT) leads to reduction of inflammatory symptoms and causes faster epithelisation in corneal ulcers and persistant epithelial defect. 21 patients with corneal ulcer (n = 18) or non-healing epithelial defect (n = 3) unresponsive to conventional treatment were included in the study. All patients were treated by AMT. Corneal epithelial cells in patients suffering from corneal ulcer secreted 3.51 +/- 1.79 of IL-1alpha, 64.27 +/- 31.53 pg/mL of TNFalpha and 209.07 +/- 201.82 pg/mL of VEGF. Levels of all 3 investigated cytokines were significantly higher as compared to controls (p < 0.005). Amniotic membranes that were used contained 775.69 +/- 613.98 pg/mL of IL-1alpha, 0.036 +/- 0.033 pg/mL of sTNF and 175.01 +/- 166.63 pg/mL of VEGF-R. Supporting effect of the AMT could be explained by the fact that AM secretes its natural antinflammatory antagonists IL-1ra, sTNF and VEGF-R.</abstract><cop>Croatia</cop><pmid>22220427</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Collegium antropologicum, 2011-09, Vol.35 Suppl 2 (Supp. 2), p.167-170 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Amnion - immunology Amnion - secretion Amnion - transplantation Blindness Corneal Ulcer - immunology Corneal Ulcer - surgery Graft Survival - immunology Humans Interleukin 1 Receptor Antagonist Protein - immunology Interleukin 1 Receptor Antagonist Protein - secretion Keratitis - immunology Keratitis - surgery Medical treatment Pharmaceuticals Prospective Studies Receptors, Vascular Endothelial Growth Factor - immunology Receptors, Vascular Endothelial Growth Factor - secretion Sight Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - secretion |
| title | Transplantation of amniotic membrane in corneal ulcers and persistant epithelial defects |
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