STK39 variation predicts the ambulatory blood pressure response to losartan in hypertensive men

Large-scale genome-wide association studies (GWASs) have identified significant associations of common genetic variants with blood pressure (BP) levels. To obtain more evidence for the role of these variants in BP regulation, we studied their association with BP responses to four different antihyper...

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Veröffentlicht in:	Hypertension research 2012-01, Vol.35 (1), p.107-114
Hauptverfasser:	Donner, Kati M, Hiltunen, Timo P, Hannila-Handelberg, Tuula, Suonsyrjä, Timo, Kontula, Kimmo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Amlodipine - pharmacology Amlodipine - therapeutic use Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Bisoprolol - pharmacology Bisoprolol - therapeutic use Blood Pressure - drug effects Blood Pressure Monitoring, Ambulatory Genotype Humans Hydrochlorothiazide - pharmacology Hydrochlorothiazide - therapeutic use Hypertension - drug therapy Hypertension - genetics Losartan - pharmacology Losartan - therapeutic use Male Middle Aged Polymorphism, Single Nucleotide Protein-Serine-Threonine Kinases - genetics
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