New Rhodamine Nitroxide Based Fluorescent Probes for Intracellular Hydroxyl Radical Identification in Living Cells
The synthesis, characteristics, and biological applications of a series of new rhodamine nitroxide fluorescent probes that enable imaging of hydroxyl radicals (•OH) in living cells are described. These probes are highly selective for •OH in aqueous solution, avoiding interference from other reactive...
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| Veröffentlicht in: | Organic letters 2012-01, Vol.14 (1), p.50-53 |
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| creator | Yapici, Nazmiye B Jockusch, Steffen Moscatelli, Alberto Mandalapu, Srinivas Rao Itagaki, Yasuhiro Bates, Dallas K Wiseman, Sherri Gibson, K. Michael Turro, Nicholas J Bi, Lanrong |
| description | The synthesis, characteristics, and biological applications of a series of new rhodamine nitroxide fluorescent probes that enable imaging of hydroxyl radicals (•OH) in living cells are described. These probes are highly selective for •OH in aqueous solution, avoiding interference from other reactive oxygen species (ROS), and they facilitate •OH imaging in biologically active samples. The robust nature of these probes (high specificity and selectivity, and facile synthesis) offer distinct advantages over previous methods for •OH detection. |
| doi_str_mv | 10.1021/ol202816m |
| format | Article |
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Michael</creatorcontrib><creatorcontrib>Turro, Nicholas J</creatorcontrib><creatorcontrib>Bi, Lanrong</creatorcontrib><title>New Rhodamine Nitroxide Based Fluorescent Probes for Intracellular Hydroxyl Radical Identification in Living Cells</title><title>Organic letters</title><addtitle>Org. Lett</addtitle><description>The synthesis, characteristics, and biological applications of a series of new rhodamine nitroxide fluorescent probes that enable imaging of hydroxyl radicals (•OH) in living cells are described. These probes are highly selective for •OH in aqueous solution, avoiding interference from other reactive oxygen species (ROS), and they facilitate •OH imaging in biologically active samples. The robust nature of these probes (high specificity and selectivity, and facile synthesis) offer distinct advantages over previous methods for •OH detection.</description><subject>Cell Line</subject><subject>Cell Survival</subject><subject>Fluorescent Dyes - analysis</subject><subject>Fluorescent Dyes - chemical synthesis</subject><subject>Humans</subject><subject>Hydroxyl Radical - analysis</subject><subject>Hydroxyl Radical - chemistry</subject><subject>Intracellular Space - chemistry</subject><subject>Molecular Structure</subject><subject>Nitrogen Oxides - analysis</subject><subject>Nitrogen Oxides - chemistry</subject><subject>Oxidative Stress</subject><subject>Rhodamines - chemistry</subject><issn>1523-7060</issn><issn>1523-7052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMFOwzAQRC0EoqVw4AeQLwhxCNix4yRHqCitVBVUwTly4jW4SuJiJ0D_HleFnjjtaPVmtDsInVNyQ0lMb20dkzijojlAQ5rELEpJEh_utSADdOL9ihAaNvkxGsQxTUWSZkPkFvCFl-9Wyca0gBemc_bbKMD30oPCk7q3DnwFbYefnS3BY20dnrWdkxXUdV9Lh6cbFUybGi-lMpWs8UwF3uigO2NbbFo8N5-mfcPjYPGn6EjL2sPZ7xyh18nDy3gazZ8eZ-O7eSQZ5V2UgEwZZEJzAZrkVOS6ZJyXZVnlRGgGOWM8YyWRlJdxkiqugNHgSrgSSlVshK52uWtnP3rwXdEYvz1atmB7X-SUC5EIQgJ5vSMrZ713oIu1M410m4KSYttwsW84sBe_qX3ZgNqTf5UG4HIHyMoXK9u7Njz5T9APDbWDxg</recordid><startdate>20120106</startdate><enddate>20120106</enddate><creator>Yapici, Nazmiye B</creator><creator>Jockusch, Steffen</creator><creator>Moscatelli, Alberto</creator><creator>Mandalapu, Srinivas Rao</creator><creator>Itagaki, Yasuhiro</creator><creator>Bates, Dallas K</creator><creator>Wiseman, Sherri</creator><creator>Gibson, K. 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Michael</au><au>Turro, Nicholas J</au><au>Bi, Lanrong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Rhodamine Nitroxide Based Fluorescent Probes for Intracellular Hydroxyl Radical Identification in Living Cells</atitle><jtitle>Organic letters</jtitle><addtitle>Org. Lett</addtitle><date>2012-01-06</date><risdate>2012</risdate><volume>14</volume><issue>1</issue><spage>50</spage><epage>53</epage><pages>50-53</pages><issn>1523-7060</issn><eissn>1523-7052</eissn><abstract>The synthesis, characteristics, and biological applications of a series of new rhodamine nitroxide fluorescent probes that enable imaging of hydroxyl radicals (•OH) in living cells are described. These probes are highly selective for •OH in aqueous solution, avoiding interference from other reactive oxygen species (ROS), and they facilitate •OH imaging in biologically active samples. 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| fulltext | fulltext |
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| ispartof | Organic letters, 2012-01, Vol.14 (1), p.50-53 |
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| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Cell Line Cell Survival Fluorescent Dyes - analysis Fluorescent Dyes - chemical synthesis Humans Hydroxyl Radical - analysis Hydroxyl Radical - chemistry Intracellular Space - chemistry Molecular Structure Nitrogen Oxides - analysis Nitrogen Oxides - chemistry Oxidative Stress Rhodamines - chemistry |
| title | New Rhodamine Nitroxide Based Fluorescent Probes for Intracellular Hydroxyl Radical Identification in Living Cells |
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