Treatment of Neonatal Sepsis with Immune Globulin
To the Editor: The International Neonatal Immunotherapy Study (INIS) Collaborative Group (Sept. 29 issue) 1 reports that therapy with intravenous immune globulin was not associated with decreased mortality in neonatal sepsis. However, many patients who were included in this study had cultures growin...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 2012-01, Vol.366 (1), p.91-91 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 91 |
|---|---|
| container_issue | 1 |
| container_start_page | 91 |
| container_title | The New England journal of medicine |
| container_volume | 366 |
| creator | Oba, Yuichiro Iwata, Kentaro Stenson, Ben Brocklehurst, Peter King, Andrew |
| description | To the Editor:
The International Neonatal Immunotherapy Study (INIS) Collaborative Group (Sept. 29 issue)
1
reports that therapy with intravenous immune globulin was not associated with decreased mortality in neonatal sepsis. However, many patients who were included in this study had cultures growing coagulase-negative staphylococci, which are usually less pathogenic and are associated with a better outcome than are coagulase-positive staphylococci. In addition, such cultures often contain contaminants from skin. Since severe sepsis was not strictly defined in this study, many patients could have conditions that were falsely diagnosed as sepsis, with relatively mild symptoms and a false positive blood culture. . . . |
| doi_str_mv | 10.1056/NEJMc1112575 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_914665220</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>914665220</sourcerecordid><originalsourceid>FETCH-LOGICAL-c346t-1a87a9b9c392b70830c2e6f8c716af47c0106f421dac4fd83202f49afc98a43e3</originalsourceid><addsrcrecordid>eNpt0MFLwzAUBvAgis7pzbMUEbxYzUvSNDnKmHMy58F5DmmWYEfTzKZF_O_t2BQR3-Vdfnx8fAidAb4BnPHb-fjxyQAAyfJsDw0gozRlDPN9NMCYiJTlkh6h4xhXuD9g8hAdEUKAi4wNECwaq1tv6zYJLpnbUOtWV8mLXccyJh9l-5ZMve9qm0yqUHRVWZ-gA6eraE93f4he78eL0UM6e55MR3ez1FDG2xS0yLUspKGSFDkWFBtiuRMmB64dyw0GzB0jsNSGuaWgBBPHpHZGCs2opUN0tc1dN-G9s7FVvozGVpWubeiiksA4zwjBvbz4I1eha-q-3AbRjFEuenS9RaYJMTbWqXVTet18KsBqM6T6PWTPz3eZXeHt8gd_L9eDyy3wPqrarvz_OV_YEnZT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>914354368</pqid></control><display><type>article</type><title>Treatment of Neonatal Sepsis with Immune Globulin</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>New England Journal of Medicine</source><creator>Oba, Yuichiro ; Iwata, Kentaro ; Stenson, Ben ; Brocklehurst, Peter ; King, Andrew</creator><creatorcontrib>Oba, Yuichiro ; Iwata, Kentaro ; Stenson, Ben ; Brocklehurst, Peter ; King, Andrew</creatorcontrib><description>To the Editor:
The International Neonatal Immunotherapy Study (INIS) Collaborative Group (Sept. 29 issue)
1
reports that therapy with intravenous immune globulin was not associated with decreased mortality in neonatal sepsis. However, many patients who were included in this study had cultures growing coagulase-negative staphylococci, which are usually less pathogenic and are associated with a better outcome than are coagulase-positive staphylococci. In addition, such cultures often contain contaminants from skin. Since severe sepsis was not strictly defined in this study, many patients could have conditions that were falsely diagnosed as sepsis, with relatively mild symptoms and a false positive blood culture. . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMc1112575</identifier><identifier>PMID: 22216854</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Blood culture ; Coagulase ; Contaminants ; Female ; Globulins ; Humans ; Immunoglobulins ; Immunoglobulins, Intravenous - therapeutic use ; Immunologic Factors - therapeutic use ; Immunotherapy ; Intravenous administration ; Male ; Neonates ; Patients ; Sepsis ; Sepsis - drug therapy ; Skin</subject><ispartof>The New England journal of medicine, 2012-01, Vol.366 (1), p.91-91</ispartof><rights>Copyright © 2012 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-1a87a9b9c392b70830c2e6f8c716af47c0106f421dac4fd83202f49afc98a43e3</citedby><cites>FETCH-LOGICAL-c346t-1a87a9b9c392b70830c2e6f8c716af47c0106f421dac4fd83202f49afc98a43e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMc1112575$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMc1112575$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22216854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oba, Yuichiro</creatorcontrib><creatorcontrib>Iwata, Kentaro</creatorcontrib><creatorcontrib>Stenson, Ben</creatorcontrib><creatorcontrib>Brocklehurst, Peter</creatorcontrib><creatorcontrib>King, Andrew</creatorcontrib><title>Treatment of Neonatal Sepsis with Immune Globulin</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
The International Neonatal Immunotherapy Study (INIS) Collaborative Group (Sept. 29 issue)
1
reports that therapy with intravenous immune globulin was not associated with decreased mortality in neonatal sepsis. However, many patients who were included in this study had cultures growing coagulase-negative staphylococci, which are usually less pathogenic and are associated with a better outcome than are coagulase-positive staphylococci. In addition, such cultures often contain contaminants from skin. Since severe sepsis was not strictly defined in this study, many patients could have conditions that were falsely diagnosed as sepsis, with relatively mild symptoms and a false positive blood culture. . . .</description><subject>Blood culture</subject><subject>Coagulase</subject><subject>Contaminants</subject><subject>Female</subject><subject>Globulins</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>Immunologic Factors - therapeutic use</subject><subject>Immunotherapy</subject><subject>Intravenous administration</subject><subject>Male</subject><subject>Neonates</subject><subject>Patients</subject><subject>Sepsis</subject><subject>Sepsis - drug therapy</subject><subject>Skin</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0MFLwzAUBvAgis7pzbMUEbxYzUvSNDnKmHMy58F5DmmWYEfTzKZF_O_t2BQR3-Vdfnx8fAidAb4BnPHb-fjxyQAAyfJsDw0gozRlDPN9NMCYiJTlkh6h4xhXuD9g8hAdEUKAi4wNECwaq1tv6zYJLpnbUOtWV8mLXccyJh9l-5ZMve9qm0yqUHRVWZ-gA6eraE93f4he78eL0UM6e55MR3ez1FDG2xS0yLUspKGSFDkWFBtiuRMmB64dyw0GzB0jsNSGuaWgBBPHpHZGCs2opUN0tc1dN-G9s7FVvozGVpWubeiiksA4zwjBvbz4I1eha-q-3AbRjFEuenS9RaYJMTbWqXVTet18KsBqM6T6PWTPz3eZXeHt8gd_L9eDyy3wPqrarvz_OV_YEnZT</recordid><startdate>20120105</startdate><enddate>20120105</enddate><creator>Oba, Yuichiro</creator><creator>Iwata, Kentaro</creator><creator>Stenson, Ben</creator><creator>Brocklehurst, Peter</creator><creator>King, Andrew</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120105</creationdate><title>Treatment of Neonatal Sepsis with Immune Globulin</title><author>Oba, Yuichiro ; Iwata, Kentaro ; Stenson, Ben ; Brocklehurst, Peter ; King, Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-1a87a9b9c392b70830c2e6f8c716af47c0106f421dac4fd83202f49afc98a43e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Blood culture</topic><topic>Coagulase</topic><topic>Contaminants</topic><topic>Female</topic><topic>Globulins</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Immunoglobulins, Intravenous - therapeutic use</topic><topic>Immunologic Factors - therapeutic use</topic><topic>Immunotherapy</topic><topic>Intravenous administration</topic><topic>Male</topic><topic>Neonates</topic><topic>Patients</topic><topic>Sepsis</topic><topic>Sepsis - drug therapy</topic><topic>Skin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oba, Yuichiro</creatorcontrib><creatorcontrib>Iwata, Kentaro</creatorcontrib><creatorcontrib>Stenson, Ben</creatorcontrib><creatorcontrib>Brocklehurst, Peter</creatorcontrib><creatorcontrib>King, Andrew</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oba, Yuichiro</au><au>Iwata, Kentaro</au><au>Stenson, Ben</au><au>Brocklehurst, Peter</au><au>King, Andrew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Neonatal Sepsis with Immune Globulin</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2012-01-05</date><risdate>2012</risdate><volume>366</volume><issue>1</issue><spage>91</spage><epage>91</epage><pages>91-91</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
The International Neonatal Immunotherapy Study (INIS) Collaborative Group (Sept. 29 issue)
1
reports that therapy with intravenous immune globulin was not associated with decreased mortality in neonatal sepsis. However, many patients who were included in this study had cultures growing coagulase-negative staphylococci, which are usually less pathogenic and are associated with a better outcome than are coagulase-positive staphylococci. In addition, such cultures often contain contaminants from skin. Since severe sepsis was not strictly defined in this study, many patients could have conditions that were falsely diagnosed as sepsis, with relatively mild symptoms and a false positive blood culture. . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>22216854</pmid><doi>10.1056/NEJMc1112575</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2012-01, Vol.366 (1), p.91-91 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_914665220 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Blood culture Coagulase Contaminants Female Globulins Humans Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Immunologic Factors - therapeutic use Immunotherapy Intravenous administration Male Neonates Patients Sepsis Sepsis - drug therapy Skin |
| title | Treatment of Neonatal Sepsis with Immune Globulin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T06%3A20%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Treatment%20of%20Neonatal%20Sepsis%20with%20Immune%20Globulin&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Oba,%20Yuichiro&rft.date=2012-01-05&rft.volume=366&rft.issue=1&rft.spage=91&rft.epage=91&rft.pages=91-91&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJMc1112575&rft_dat=%3Cproquest_cross%3E914665220%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=914354368&rft_id=info:pmid/22216854&rfr_iscdi=true |