Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel

Both osteoporosis and high blood pressure are major diseases in aging populations. Recent studies demonstrated that some antihypertensive drugs reduced the risk of bone fracture in elderly patients. Although calcium channel blockers (CCB) are widely used as first-line antihypertensive agents, there...

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Veröffentlicht in:	Hypertension research 2012-01, Vol.35 (1), p.77-81
Hauptverfasser:	Shimizu, Hideo, Nakagami, Hironori, Yasumasa, Natsuki, Mariana, Osako Kiomy, Kyutoku, Mariko, Koriyama, Hiroshi, Nakagami, Futoshi, Shimamura, Munehisa, Rakugi, Hiromi, Morishita, Ryuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amlodipine - pharmacology Amlodipine - therapeutic use Animals Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Bone and Bones - drug effects Bone and Bones - metabolism Bone Density - drug effects Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Calcium Channels, N-Type - metabolism Dihydropyridines - pharmacology Dihydropyridines - therapeutic use Female Osteoporosis - drug therapy Ovariectomy Rats Rats, Inbred SHR
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