Vegetarianism, bone loss, fracture and vitamin D: a longitudinal study in Asian vegans and non-vegans
Background/Objectives: The effect of vegan diet on bone loss has not been studied. The aim of this study was to examine the association between veganism and bone loss in postmenopausal women. Subjects/Methods: The study was designed as a prospective longitudinal investigation with 210 women, includi...
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| Veröffentlicht in: | European journal of clinical nutrition 2012-01, Vol.66 (1), p.75-82 |
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| creator | Ho-Pham, L T Vu, B Q Lai, T Q Nguyen, N D Nguyen, T V |
| description | Background/Objectives:
The effect of vegan diet on bone loss has not been studied. The aim of this study was to examine the association between veganism and bone loss in postmenopausal women.
Subjects/Methods:
The study was designed as a prospective longitudinal investigation with 210 women, including 105 vegans and 105 omnivores. Femoral neck (FN) bone mineral density (BMD) was measured in 2008 and 2010 by dual-energy X-ray absorptiometry (Hologic QDR4500). The incidence of vertebral fracture was ascertained by X-ray report. Serum levels of C-terminal telopeptide of type I collagen (βCTX) and N-terminal propeptide of type I procollagen (PINP) were measured by Roche Elecsys assays. Serum concentration of 25-hydroxyvitamin D and parathyroid hormone were measured by electrochemiluminescence.
Results:
Among the 210 women who initially participated in the study in 2008, 181 women had completed the study and 29 women were lost to follow-up. The rate of loss in FN BMD was −1.91±3.45%/year in omnivores and −0.86±3.81%/year (
P
=0.08) in vegans. Lower body weight, higher intakes of animal protein and lipid, and corticosteroid use were associated with greater rate of bone loss. The 2-year incidence of fracture was 5.7% (
n
=5/88) in vegans, which was not significantly different from omnivores (5.4%,
n
=6/93). There were no significant differences in βCTX and PINP between vegans and omnivores. The prevalence of vitamin D insufficiency in vegans was higher than in omnivores (73% versus 46%;
P
=0.0003).
Conclusions:
Vegan diet did not have adverse effect on bone loss and fracture. Corticosteroid use and high intakes of animal protein and animal lipid were negatively associated with bone loss. |
| doi_str_mv | 10.1038/ejcn.2011.131 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_914299950</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A277270613</galeid><sourcerecordid>A277270613</sourcerecordid><originalsourceid>FETCH-LOGICAL-c596t-5e5269b2587bbdba20c27cc11e729fb01dfe89ecc12fb9c5ca32a8db2854efa23</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhiMEokvhyBVZIAqHZrGddRxzW5VPqRIX4BpNnEnqVeIUO6nUf8-ku7CAIuSDP-aZsef1myRPBV8LnhVvcGf9WnIh1iIT95KV2Og8VfmG309W3KhNmnGuT5JHMe44p6CWD5MTKQohpMlWCX7HFkcIDryL_TmrBo-sG2I8Z00AO04BGfia3bgReufZu7cMKO5bN06189CxSItbRqFtpCLsBlvw8S7HDz7dbx8nDxroIj45zKfJtw_vv158Si-_fPx8sb1MrTL5mCpUMjeVVIWuqroCya3U1gqBWpqm4qJusDBIJ7KpjFUWMglFXclCbbABmZ0mr_Z1r8PwY8I4lr2LFrsOPA5TLI3YSGOM4kS-_i8puCy4lDpXhD7_B90NU6DW53p5lhmlNEEv9lALHZbON8NI8s01y60k0TXPRUZUukC16DEAiYqNo-O_-PUCT6PG3tnFhLM_Eq4QuvEqDt00usHHxZfYQJ8dsCmvg-sh3FLn5WyscjZWORurJGMR_-wgwlT1WP-mfzmJgJcHAKKFjszjrYtHjkQSptDHliKFfIvhqObyzT8BGfTiHA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>916339557</pqid></control><display><type>article</type><title>Vegetarianism, bone loss, fracture and vitamin D: a longitudinal study in Asian vegans and non-vegans</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Ho-Pham, L T ; Vu, B Q ; Lai, T Q ; Nguyen, N D ; Nguyen, T V</creator><creatorcontrib>Ho-Pham, L T ; Vu, B Q ; Lai, T Q ; Nguyen, N D ; Nguyen, T V</creatorcontrib><description>Background/Objectives:
The effect of vegan diet on bone loss has not been studied. The aim of this study was to examine the association between veganism and bone loss in postmenopausal women.
Subjects/Methods:
The study was designed as a prospective longitudinal investigation with 210 women, including 105 vegans and 105 omnivores. Femoral neck (FN) bone mineral density (BMD) was measured in 2008 and 2010 by dual-energy X-ray absorptiometry (Hologic QDR4500). The incidence of vertebral fracture was ascertained by X-ray report. Serum levels of C-terminal telopeptide of type I collagen (βCTX) and N-terminal propeptide of type I procollagen (PINP) were measured by Roche Elecsys assays. Serum concentration of 25-hydroxyvitamin D and parathyroid hormone were measured by electrochemiluminescence.
Results:
Among the 210 women who initially participated in the study in 2008, 181 women had completed the study and 29 women were lost to follow-up. The rate of loss in FN BMD was −1.91±3.45%/year in omnivores and −0.86±3.81%/year (
P
=0.08) in vegans. Lower body weight, higher intakes of animal protein and lipid, and corticosteroid use were associated with greater rate of bone loss. The 2-year incidence of fracture was 5.7% (
n
=5/88) in vegans, which was not significantly different from omnivores (5.4%,
n
=6/93). There were no significant differences in βCTX and PINP between vegans and omnivores. The prevalence of vitamin D insufficiency in vegans was higher than in omnivores (73% versus 46%;
P
=0.0003).
Conclusions:
Vegan diet did not have adverse effect on bone loss and fracture. Corticosteroid use and high intakes of animal protein and animal lipid were negatively associated with bone loss.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2011.131</identifier><identifier>PMID: 21811293</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Absorptiometry, Photon ; Adrenal Cortex Hormones - adverse effects ; Aged ; Asian Continental Ancestry Group ; Asian people ; Biological and medical sciences ; Body Weight ; Bone Density ; Bone mineral density ; Bone Resorption - blood ; Bone Resorption - etiology ; Bones ; Clinical Nutrition ; Collagen Type I - blood ; Density ; Diet ; Diet, Vegetarian - adverse effects ; Dietary Fats - adverse effects ; Dietary Proteins - adverse effects ; Diseases of the osteoarticular system ; Epidemiology ; Feeding Behavior ; Feeding. Feeding behavior ; Female ; Fractures ; Fractures, Bone ; Fundamental and applied biological sciences. Psychology ; Health aspects ; Humans ; Internal Medicine ; Longitudinal Studies ; Lost to Follow-Up ; Medical sciences ; Medicine ; Medicine & Public Health ; Menopause ; Metabolic Diseases ; Middle Aged ; Omnivores ; original-article ; Osteoporosis, Postmenopausal - blood ; Osteoporosis, Postmenopausal - etiology ; Osteoporosis. Osteomalacia. Paget disease ; Peptides - blood ; Physiological aspects ; Prevalence ; Prospective Studies ; Public Health ; Risk factors ; Veganism ; Vegetarianism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vietnam - epidemiology ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - epidemiology ; Women ; Womens health</subject><ispartof>European journal of clinical nutrition, 2012-01, Vol.66 (1), p.75-82</ispartof><rights>Macmillan Publishers Limited 2012</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596t-5e5269b2587bbdba20c27cc11e729fb01dfe89ecc12fb9c5ca32a8db2854efa23</citedby><cites>FETCH-LOGICAL-c596t-5e5269b2587bbdba20c27cc11e729fb01dfe89ecc12fb9c5ca32a8db2854efa23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ejcn.2011.131$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ejcn.2011.131$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25571987$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21811293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ho-Pham, L T</creatorcontrib><creatorcontrib>Vu, B Q</creatorcontrib><creatorcontrib>Lai, T Q</creatorcontrib><creatorcontrib>Nguyen, N D</creatorcontrib><creatorcontrib>Nguyen, T V</creatorcontrib><title>Vegetarianism, bone loss, fracture and vitamin D: a longitudinal study in Asian vegans and non-vegans</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives:
The effect of vegan diet on bone loss has not been studied. The aim of this study was to examine the association between veganism and bone loss in postmenopausal women.
Subjects/Methods:
The study was designed as a prospective longitudinal investigation with 210 women, including 105 vegans and 105 omnivores. Femoral neck (FN) bone mineral density (BMD) was measured in 2008 and 2010 by dual-energy X-ray absorptiometry (Hologic QDR4500). The incidence of vertebral fracture was ascertained by X-ray report. Serum levels of C-terminal telopeptide of type I collagen (βCTX) and N-terminal propeptide of type I procollagen (PINP) were measured by Roche Elecsys assays. Serum concentration of 25-hydroxyvitamin D and parathyroid hormone were measured by electrochemiluminescence.
Results:
Among the 210 women who initially participated in the study in 2008, 181 women had completed the study and 29 women were lost to follow-up. The rate of loss in FN BMD was −1.91±3.45%/year in omnivores and −0.86±3.81%/year (
P
=0.08) in vegans. Lower body weight, higher intakes of animal protein and lipid, and corticosteroid use were associated with greater rate of bone loss. The 2-year incidence of fracture was 5.7% (
n
=5/88) in vegans, which was not significantly different from omnivores (5.4%,
n
=6/93). There were no significant differences in βCTX and PINP between vegans and omnivores. The prevalence of vitamin D insufficiency in vegans was higher than in omnivores (73% versus 46%;
P
=0.0003).
Conclusions:
Vegan diet did not have adverse effect on bone loss and fracture. Corticosteroid use and high intakes of animal protein and animal lipid were negatively associated with bone loss.</description><subject>Absorptiometry, Photon</subject><subject>Adrenal Cortex Hormones - adverse effects</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group</subject><subject>Asian people</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Bone Density</subject><subject>Bone mineral density</subject><subject>Bone Resorption - blood</subject><subject>Bone Resorption - etiology</subject><subject>Bones</subject><subject>Clinical Nutrition</subject><subject>Collagen Type I - blood</subject><subject>Density</subject><subject>Diet</subject><subject>Diet, Vegetarian - adverse effects</subject><subject>Dietary Fats - adverse effects</subject><subject>Dietary Proteins - adverse effects</subject><subject>Diseases of the osteoarticular system</subject><subject>Epidemiology</subject><subject>Feeding Behavior</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fractures</subject><subject>Fractures, Bone</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Longitudinal Studies</subject><subject>Lost to Follow-Up</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menopause</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Omnivores</subject><subject>original-article</subject><subject>Osteoporosis, Postmenopausal - blood</subject><subject>Osteoporosis, Postmenopausal - etiology</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Peptides - blood</subject><subject>Physiological aspects</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Public Health</subject><subject>Risk factors</subject><subject>Veganism</subject><subject>Vegetarianism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vietnam - epidemiology</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Women</subject><subject>Womens health</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kk1v1DAQhiMEokvhyBVZIAqHZrGddRxzW5VPqRIX4BpNnEnqVeIUO6nUf8-ku7CAIuSDP-aZsef1myRPBV8LnhVvcGf9WnIh1iIT95KV2Og8VfmG309W3KhNmnGuT5JHMe44p6CWD5MTKQohpMlWCX7HFkcIDryL_TmrBo-sG2I8Z00AO04BGfia3bgReufZu7cMKO5bN06189CxSItbRqFtpCLsBlvw8S7HDz7dbx8nDxroIj45zKfJtw_vv158Si-_fPx8sb1MrTL5mCpUMjeVVIWuqroCya3U1gqBWpqm4qJusDBIJ7KpjFUWMglFXclCbbABmZ0mr_Z1r8PwY8I4lr2LFrsOPA5TLI3YSGOM4kS-_i8puCy4lDpXhD7_B90NU6DW53p5lhmlNEEv9lALHZbON8NI8s01y60k0TXPRUZUukC16DEAiYqNo-O_-PUCT6PG3tnFhLM_Eq4QuvEqDt00usHHxZfYQJ8dsCmvg-sh3FLn5WyscjZWORurJGMR_-wgwlT1WP-mfzmJgJcHAKKFjszjrYtHjkQSptDHliKFfIvhqObyzT8BGfTiHA</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Ho-Pham, L T</creator><creator>Vu, B Q</creator><creator>Lai, T Q</creator><creator>Nguyen, N D</creator><creator>Nguyen, T V</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120101</creationdate><title>Vegetarianism, bone loss, fracture and vitamin D: a longitudinal study in Asian vegans and non-vegans</title><author>Ho-Pham, L T ; Vu, B Q ; Lai, T Q ; Nguyen, N D ; Nguyen, T V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c596t-5e5269b2587bbdba20c27cc11e729fb01dfe89ecc12fb9c5ca32a8db2854efa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Absorptiometry, Photon</topic><topic>Adrenal Cortex Hormones - adverse effects</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group</topic><topic>Asian people</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Bone Density</topic><topic>Bone mineral density</topic><topic>Bone Resorption - blood</topic><topic>Bone Resorption - etiology</topic><topic>Bones</topic><topic>Clinical Nutrition</topic><topic>Collagen Type I - blood</topic><topic>Density</topic><topic>Diet</topic><topic>Diet, Vegetarian - adverse effects</topic><topic>Dietary Fats - adverse effects</topic><topic>Dietary Proteins - adverse effects</topic><topic>Diseases of the osteoarticular system</topic><topic>Epidemiology</topic><topic>Feeding Behavior</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fractures</topic><topic>Fractures, Bone</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Longitudinal Studies</topic><topic>Lost to Follow-Up</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menopause</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Omnivores</topic><topic>original-article</topic><topic>Osteoporosis, Postmenopausal - blood</topic><topic>Osteoporosis, Postmenopausal - etiology</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Peptides - blood</topic><topic>Physiological aspects</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Public Health</topic><topic>Risk factors</topic><topic>Veganism</topic><topic>Vegetarianism</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vietnam - epidemiology</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Women</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ho-Pham, L T</creatorcontrib><creatorcontrib>Vu, B Q</creatorcontrib><creatorcontrib>Lai, T Q</creatorcontrib><creatorcontrib>Nguyen, N D</creatorcontrib><creatorcontrib>Nguyen, T V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ho-Pham, L T</au><au>Vu, B Q</au><au>Lai, T Q</au><au>Nguyen, N D</au><au>Nguyen, T V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vegetarianism, bone loss, fracture and vitamin D: a longitudinal study in Asian vegans and non-vegans</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>66</volume><issue>1</issue><spage>75</spage><epage>82</epage><pages>75-82</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background/Objectives:
The effect of vegan diet on bone loss has not been studied. The aim of this study was to examine the association between veganism and bone loss in postmenopausal women.
Subjects/Methods:
The study was designed as a prospective longitudinal investigation with 210 women, including 105 vegans and 105 omnivores. Femoral neck (FN) bone mineral density (BMD) was measured in 2008 and 2010 by dual-energy X-ray absorptiometry (Hologic QDR4500). The incidence of vertebral fracture was ascertained by X-ray report. Serum levels of C-terminal telopeptide of type I collagen (βCTX) and N-terminal propeptide of type I procollagen (PINP) were measured by Roche Elecsys assays. Serum concentration of 25-hydroxyvitamin D and parathyroid hormone were measured by electrochemiluminescence.
Results:
Among the 210 women who initially participated in the study in 2008, 181 women had completed the study and 29 women were lost to follow-up. The rate of loss in FN BMD was −1.91±3.45%/year in omnivores and −0.86±3.81%/year (
P
=0.08) in vegans. Lower body weight, higher intakes of animal protein and lipid, and corticosteroid use were associated with greater rate of bone loss. The 2-year incidence of fracture was 5.7% (
n
=5/88) in vegans, which was not significantly different from omnivores (5.4%,
n
=6/93). There were no significant differences in βCTX and PINP between vegans and omnivores. The prevalence of vitamin D insufficiency in vegans was higher than in omnivores (73% versus 46%;
P
=0.0003).
Conclusions:
Vegan diet did not have adverse effect on bone loss and fracture. Corticosteroid use and high intakes of animal protein and animal lipid were negatively associated with bone loss.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21811293</pmid><doi>10.1038/ejcn.2011.131</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2012-01, Vol.66 (1), p.75-82 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_914299950 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Absorptiometry, Photon Adrenal Cortex Hormones - adverse effects Aged Asian Continental Ancestry Group Asian people Biological and medical sciences Body Weight Bone Density Bone mineral density Bone Resorption - blood Bone Resorption - etiology Bones Clinical Nutrition Collagen Type I - blood Density Diet Diet, Vegetarian - adverse effects Dietary Fats - adverse effects Dietary Proteins - adverse effects Diseases of the osteoarticular system Epidemiology Feeding Behavior Feeding. Feeding behavior Female Fractures Fractures, Bone Fundamental and applied biological sciences. Psychology Health aspects Humans Internal Medicine Longitudinal Studies Lost to Follow-Up Medical sciences Medicine Medicine & Public Health Menopause Metabolic Diseases Middle Aged Omnivores original-article Osteoporosis, Postmenopausal - blood Osteoporosis, Postmenopausal - etiology Osteoporosis. Osteomalacia. Paget disease Peptides - blood Physiological aspects Prevalence Prospective Studies Public Health Risk factors Veganism Vegetarianism Vertebrates: anatomy and physiology, studies on body, several organs or systems Vietnam - epidemiology Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - epidemiology Women Womens health |
| title | Vegetarianism, bone loss, fracture and vitamin D: a longitudinal study in Asian vegans and non-vegans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T05%3A15%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vegetarianism,%20bone%20loss,%20fracture%20and%20vitamin%20D:%20a%20longitudinal%20study%20in%20Asian%20vegans%20and%20non-vegans&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=Ho-Pham,%20L%20T&rft.date=2012-01-01&rft.volume=66&rft.issue=1&rft.spage=75&rft.epage=82&rft.pages=75-82&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/ejcn.2011.131&rft_dat=%3Cgale_proqu%3EA277270613%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=916339557&rft_id=info:pmid/21811293&rft_galeid=A277270613&rfr_iscdi=true |