Functional characterisation of the bovine neuropeptide Y gene promoter and evaluation of the transcriptional activities of promoter haplotypes

Neuropeptide Y (NPY) is a potent orexigenic agent. The molecular mechanisms underlying the regulation of bovine NPY gene expression by its promoter region is currently unknown. The objectives of this research were to: (i) identify the SNPs in the promoter region of the bovine NPY gene, (ii) investig...

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Veröffentlicht in:	Molecular biology reports 2012-02, Vol.39 (2), p.919-928
Hauptverfasser:	Alam, Tanweer, Bahar, Bojlul, Waters, Sinéad M., McGee, Mark, O’Doherty, John V., Sweeney, Torres
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Animals Base Sequence Biomedical and Life Sciences Cattle - genetics DNA Primers - genetics Enhancers Gene expression Gene Expression Regulation - genetics Genetic Variation Guanylate cyclase Haplotypes Haplotypes - genetics Histology Life Sciences Linear Models Linkage Disequilibrium Molecular biology Molecular modelling Molecular Sequence Data Morphology Neuropeptide Y Neuropeptide Y - genetics Neuropeptide Y - metabolism Peptides Polymerase Chain Reaction Polymorphism Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic - genetics Promoters Protein Interaction Domains and Motifs - genetics Repressors Sequence Analysis, DNA Single-nucleotide polymorphism Sp1 protein Tata box TATA-binding protein Transcription factors
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