Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature
We present the case of a 60‐year‐old male with known stage IA mycosis fungoides (MF) who developed a suspicious tumor within a pre‐existing lymphomatous plaque of the right forearm. Microscopy revealed an unusual mixed fibrohistiocytic proliferation as well as atypical intraepidermal and dermal lymp...
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| Veröffentlicht in: | Journal of cutaneous pathology 2012-01, Vol.39 (1), p.40-46 |
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| creator | Morcos, Sarah M. Girardi, Michael Subtil, Antonio Wilson, Lynn D. Cowper, Shawn E. |
| description | We present the case of a 60‐year‐old male with known stage IA mycosis fungoides (MF) who developed a suspicious tumor within a pre‐existing lymphomatous plaque of the right forearm. Microscopy revealed an unusual mixed fibrohistiocytic proliferation as well as atypical intraepidermal and dermal lymphocytes. There was no evidence of large‐cell transformation. Histopathological, immunohistochemical and clinical clues suggest this lesion might not have represented a dermatofibroma, but rather a hitherto unreported dermatofibroma‐like process arising within a lesion of MF. The potential impact of this atypical lesion on the prognosis and clinical management of this patient highlights the importance of recognizing unusual clinical presentations of more common, benign lesions within this patient population.
Morcos SM, Girardi M, Subtil A, Wilson LD, Cowper SE. Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature. |
| doi_str_mv | 10.1111/j.1600-0560.2011.01804.x |
| format | Article |
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Morcos SM, Girardi M, Subtil A, Wilson LD, Cowper SE. Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/j.1600-0560.2011.01804.x</identifier><identifier>PMID: 22059953</identifier><identifier>CODEN: JCUPBN</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Cell Proliferation ; cutaneous T-cell lymphoma ; dermatofibroma ; Dermatology ; Dermis - metabolism ; Dermis - pathology ; Diagnosis, Differential ; fibrotic ; Hematologic and hematopoietic diseases ; Histiocytoma, Benign Fibrous - metabolism ; Histiocytoma, Benign Fibrous - pathology ; Humans ; Immunohistochemistry - methods ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocytes - metabolism ; Lymphocytes - pathology ; Male ; Medical sciences ; Middle Aged ; mycosis fungoides ; Mycosis Fungoides - metabolism ; Mycosis Fungoides - pathology ; Neoplasm Staging ; simulant ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology</subject><ispartof>Journal of cutaneous pathology, 2012-01, Vol.39 (1), p.40-46</ispartof><rights>Copyright © 2011 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4364-73a9da6cef22807fee57929f013299b732a5ed3d0743c7faceaa5c70e44f2b8e3</citedby><cites>FETCH-LOGICAL-c4364-73a9da6cef22807fee57929f013299b732a5ed3d0743c7faceaa5c70e44f2b8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0560.2011.01804.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0560.2011.01804.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25298592$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22059953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morcos, Sarah M.</creatorcontrib><creatorcontrib>Girardi, Michael</creatorcontrib><creatorcontrib>Subtil, Antonio</creatorcontrib><creatorcontrib>Wilson, Lynn D.</creatorcontrib><creatorcontrib>Cowper, Shawn E.</creatorcontrib><title>Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>We present the case of a 60‐year‐old male with known stage IA mycosis fungoides (MF) who developed a suspicious tumor within a pre‐existing lymphomatous plaque of the right forearm. Microscopy revealed an unusual mixed fibrohistiocytic proliferation as well as atypical intraepidermal and dermal lymphocytes. There was no evidence of large‐cell transformation. Histopathological, immunohistochemical and clinical clues suggest this lesion might not have represented a dermatofibroma, but rather a hitherto unreported dermatofibroma‐like process arising within a lesion of MF. The potential impact of this atypical lesion on the prognosis and clinical management of this patient highlights the importance of recognizing unusual clinical presentations of more common, benign lesions within this patient population.
Morcos SM, Girardi M, Subtil A, Wilson LD, Cowper SE. Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature.</description><subject>Biological and medical sciences</subject><subject>Cell Proliferation</subject><subject>cutaneous T-cell lymphoma</subject><subject>dermatofibroma</subject><subject>Dermatology</subject><subject>Dermis - metabolism</subject><subject>Dermis - pathology</subject><subject>Diagnosis, Differential</subject><subject>fibrotic</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Histiocytoma, Benign Fibrous - metabolism</subject><subject>Histiocytoma, Benign Fibrous - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mycosis fungoides</subject><subject>Mycosis Fungoides - metabolism</subject><subject>Mycosis Fungoides - pathology</subject><subject>Neoplasm Staging</subject><subject>simulant</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1v0zAUhi3ExLrCX0C5QVwl-COOYyQuUFk3pHWAxAR3luMcby75KHaytf9-ztqVW3zjo-PnPcd6EEoIzkg8H9YZKTBOMS9wRjEhGSYlzrPtCzQ7PrxEM8wwSwtZilN0FsIaY1KUBX-FTinFXErOZghWO9MHFxI7dre9qyEksL1zlRtcd5tY0MPoY6-3iU5q8K0eeusq37f6Y-wYHSDxsOn9kOiujuW9g4eJHu4gadwA_mnAa3RidRPgzeGeo5vl-c_FZXr17eLr4vNVanJW5KlgWta6MGApLbGwAFxIKi0mjEpZCUY1h5rVWOTMCKsNaM2NwJDnllYlsDl6v5-78f3fEcKgWhcMNI3uoB-DkoSJ6CtqmaNyTxrfh-DBqo13rfY7RbCaHKu1mlSqSaWaHKsnx2obo28PS8aqhfoYfJYagXcHQAejG-t1Z1z4x3EqSy5p5D7tuQfXwO6_P6AWN9-nKubTfd6FAbbHvPZ_VCGY4OrX9YX6_WV1uVxer9QP9gj_XqfL</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Morcos, Sarah M.</creator><creator>Girardi, Michael</creator><creator>Subtil, Antonio</creator><creator>Wilson, Lynn D.</creator><creator>Cowper, Shawn E.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature</title><author>Morcos, Sarah M. ; Girardi, Michael ; Subtil, Antonio ; Wilson, Lynn D. ; Cowper, Shawn E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4364-73a9da6cef22807fee57929f013299b732a5ed3d0743c7faceaa5c70e44f2b8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Cell Proliferation</topic><topic>cutaneous T-cell lymphoma</topic><topic>dermatofibroma</topic><topic>Dermatology</topic><topic>Dermis - metabolism</topic><topic>Dermis - pathology</topic><topic>Diagnosis, Differential</topic><topic>fibrotic</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Histiocytoma, Benign Fibrous - metabolism</topic><topic>Histiocytoma, Benign Fibrous - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mycosis fungoides</topic><topic>Mycosis Fungoides - metabolism</topic><topic>Mycosis Fungoides - pathology</topic><topic>Neoplasm Staging</topic><topic>simulant</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morcos, Sarah M.</creatorcontrib><creatorcontrib>Girardi, Michael</creatorcontrib><creatorcontrib>Subtil, Antonio</creatorcontrib><creatorcontrib>Wilson, Lynn D.</creatorcontrib><creatorcontrib>Cowper, Shawn E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morcos, Sarah M.</au><au>Girardi, Michael</au><au>Subtil, Antonio</au><au>Wilson, Lynn D.</au><au>Cowper, Shawn E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>2012-01</date><risdate>2012</risdate><volume>39</volume><issue>1</issue><spage>40</spage><epage>46</epage><pages>40-46</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><coden>JCUPBN</coden><abstract>We present the case of a 60‐year‐old male with known stage IA mycosis fungoides (MF) who developed a suspicious tumor within a pre‐existing lymphomatous plaque of the right forearm. Microscopy revealed an unusual mixed fibrohistiocytic proliferation as well as atypical intraepidermal and dermal lymphocytes. There was no evidence of large‐cell transformation. Histopathological, immunohistochemical and clinical clues suggest this lesion might not have represented a dermatofibroma, but rather a hitherto unreported dermatofibroma‐like process arising within a lesion of MF. The potential impact of this atypical lesion on the prognosis and clinical management of this patient highlights the importance of recognizing unusual clinical presentations of more common, benign lesions within this patient population.
Morcos SM, Girardi M, Subtil A, Wilson LD, Cowper SE. Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22059953</pmid><doi>10.1111/j.1600-0560.2011.01804.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological and medical sciences Cell Proliferation cutaneous T-cell lymphoma dermatofibroma Dermatology Dermis - metabolism Dermis - pathology Diagnosis, Differential fibrotic Hematologic and hematopoietic diseases Histiocytoma, Benign Fibrous - metabolism Histiocytoma, Benign Fibrous - pathology Humans Immunohistochemistry - methods Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes - metabolism Lymphocytes - pathology Male Medical sciences Middle Aged mycosis fungoides Mycosis Fungoides - metabolism Mycosis Fungoides - pathology Neoplasm Staging simulant Skin Neoplasms - metabolism Skin Neoplasms - pathology |
| title | Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature |
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