Significance of vascular endothelial growth factor, interleukin-18 and nitric oxide in patients with breast cancer: correlation with carbohydrate antigen 15.3
The aim of this study was to determine serum concentrations of angiogenic factors including vascular endothelial growth factor (VEGF), interleukin 18 (IL-18) and nitric oxide (NO) in patients with breast cancer and to evaluate whether these factors will be correlated with CA 15.3, as a routine tumor...
Gespeichert in:
| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2011-12, Vol.28 (Suppl 1), p.15-21 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 21 |
|---|---|
| container_issue | Suppl 1 |
| container_start_page | 15 |
| container_title | Medical oncology (Northwood, London, England) |
| container_volume | 28 |
| creator | Metwally, Fatehya M. EL-mezayen, Hatem A. Ahmed, Hanaa H. |
| description | The aim of this study was to determine serum concentrations of angiogenic factors including vascular endothelial growth factor (VEGF), interleukin 18 (IL-18) and nitric oxide (NO) in patients with breast cancer and to evaluate whether these factors will be correlated with CA 15.3, as a routine tumor marker for breast cancer or not. This study was conducted on 44 patients with breast cancer and 15 healthy individuals as a control group. The results demonstrated significant increase in serum IL-18, NO and CA 15.3 levels in sera of breast cancer patients when compared to those of the control group (
P
|
| doi_str_mv | 10.1007/s12032-010-9657-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_913719834</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>913719834</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-48f50866fb21cd4d4d0196a71556f93ddaed24bb9e35ccee52350b05b29dee733</originalsourceid><addsrcrecordid>eNp1kU9vFSEUxSfGxtbqB3BjiBs3Tr3AMAzumsZ_SRMXauKOMHDnPeo8eAJj7ZfpZy11ak1MDAsI53fOJZymeUbhhALI15ky4KwFCq3qhWzZg-aICqFayum3h_XM6yWIHg6bxzlfADAqmHrUHDKQTAwgj5rrz34T_OStCRZJnMhPk-0ym0QwuFi2OHszk02Kl2VLJmNLTK-IDwXTjMt3H1o6EBMcCb4kb0n85R1WnexN8RhKJpe-GseEJhfye0h6Q2xMCedKxLDq1qQxbq9cMgVrXPEbDISKE_6kOZjMnPHp3X7cfH339svZh_b80_uPZ6fnreUSStsNk4Ch76eRUeu6uoCq3sj6Gf2kuHMGHevGUSEX1iIKxgWMIEamHKLk_Lh5uebuU_yxYC5657PFeTYB45K1olxSNfCuki_-IS_ikkJ9XIUYU0OnZIXoCtkUc0446X3yO5OuNAV9W51eq9O1On1bnWbV8_wueBl36O4df7qqAFuBXKWwwfR38v9TbwAgU6ZW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>912298497</pqid></control><display><type>article</type><title>Significance of vascular endothelial growth factor, interleukin-18 and nitric oxide in patients with breast cancer: correlation with carbohydrate antigen 15.3</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Metwally, Fatehya M. ; EL-mezayen, Hatem A. ; Ahmed, Hanaa H.</creator><creatorcontrib>Metwally, Fatehya M. ; EL-mezayen, Hatem A. ; Ahmed, Hanaa H.</creatorcontrib><description>The aim of this study was to determine serum concentrations of angiogenic factors including vascular endothelial growth factor (VEGF), interleukin 18 (IL-18) and nitric oxide (NO) in patients with breast cancer and to evaluate whether these factors will be correlated with CA 15.3, as a routine tumor marker for breast cancer or not. This study was conducted on 44 patients with breast cancer and 15 healthy individuals as a control group. The results demonstrated significant increase in serum IL-18, NO and CA 15.3 levels in sera of breast cancer patients when compared to those of the control group (
P
< 0.001,
P
= 0.016 and
P
< 0.001, respectively). However, the mean serum level of VEGF in patients as showed insignificant increase compared to that of the controls was not significant (
P
= 0.311). Sensitivity of CA 15.3, VEGF, IL-18 and NO to detect patients with disease was 52.2, 21.3, 77.2 and 70.4 %, respectively. In addition, positive status of serum CA 15.3 and/or IL-18 was found in 39 out of 44 (88.6 %) patients, and the positive status of serum CA 15.3 and/or NO was only found in 35 out of 44 (79.5 %). In conclusion, the simultaneous determination of IL-18 or NO in combination with the CA 15.3 may increase the sensitivity to diagnose breast cancer and may aid in disease prognosis.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-010-9657-2</identifier><identifier>PMID: 20725807</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Biomarkers, Tumor - blood ; Breast cancer ; Breast Neoplasms - blood ; Breast Neoplasms - diagnosis ; Case-Control Studies ; Female ; Hematology ; Humans ; Interleukin-18 - blood ; Internal Medicine ; Medicine ; Medicine & Public Health ; Middle Aged ; Mucin-1 - blood ; Nitric Oxide - blood ; Oncology ; Original Paper ; Pathology ; Vascular Endothelial Growth Factor A - blood ; Young Adult</subject><ispartof>Medical oncology (Northwood, London, England), 2011-12, Vol.28 (Suppl 1), p.15-21</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-48f50866fb21cd4d4d0196a71556f93ddaed24bb9e35ccee52350b05b29dee733</citedby><cites>FETCH-LOGICAL-c370t-48f50866fb21cd4d4d0196a71556f93ddaed24bb9e35ccee52350b05b29dee733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-010-9657-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-010-9657-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20725807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Metwally, Fatehya M.</creatorcontrib><creatorcontrib>EL-mezayen, Hatem A.</creatorcontrib><creatorcontrib>Ahmed, Hanaa H.</creatorcontrib><title>Significance of vascular endothelial growth factor, interleukin-18 and nitric oxide in patients with breast cancer: correlation with carbohydrate antigen 15.3</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>The aim of this study was to determine serum concentrations of angiogenic factors including vascular endothelial growth factor (VEGF), interleukin 18 (IL-18) and nitric oxide (NO) in patients with breast cancer and to evaluate whether these factors will be correlated with CA 15.3, as a routine tumor marker for breast cancer or not. This study was conducted on 44 patients with breast cancer and 15 healthy individuals as a control group. The results demonstrated significant increase in serum IL-18, NO and CA 15.3 levels in sera of breast cancer patients when compared to those of the control group (
P
< 0.001,
P
= 0.016 and
P
< 0.001, respectively). However, the mean serum level of VEGF in patients as showed insignificant increase compared to that of the controls was not significant (
P
= 0.311). Sensitivity of CA 15.3, VEGF, IL-18 and NO to detect patients with disease was 52.2, 21.3, 77.2 and 70.4 %, respectively. In addition, positive status of serum CA 15.3 and/or IL-18 was found in 39 out of 44 (88.6 %) patients, and the positive status of serum CA 15.3 and/or NO was only found in 35 out of 44 (79.5 %). In conclusion, the simultaneous determination of IL-18 or NO in combination with the CA 15.3 may increase the sensitivity to diagnose breast cancer and may aid in disease prognosis.</description><subject>Adult</subject><subject>Biomarkers, Tumor - blood</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Interleukin-18 - blood</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mucin-1 - blood</subject><subject>Nitric Oxide - blood</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><subject>Young Adult</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU9vFSEUxSfGxtbqB3BjiBs3Tr3AMAzumsZ_SRMXauKOMHDnPeo8eAJj7ZfpZy11ak1MDAsI53fOJZymeUbhhALI15ky4KwFCq3qhWzZg-aICqFayum3h_XM6yWIHg6bxzlfADAqmHrUHDKQTAwgj5rrz34T_OStCRZJnMhPk-0ym0QwuFi2OHszk02Kl2VLJmNLTK-IDwXTjMt3H1o6EBMcCb4kb0n85R1WnexN8RhKJpe-GseEJhfye0h6Q2xMCedKxLDq1qQxbq9cMgVrXPEbDISKE_6kOZjMnPHp3X7cfH339svZh_b80_uPZ6fnreUSStsNk4Ch76eRUeu6uoCq3sj6Gf2kuHMGHevGUSEX1iIKxgWMIEamHKLk_Lh5uebuU_yxYC5657PFeTYB45K1olxSNfCuki_-IS_ikkJ9XIUYU0OnZIXoCtkUc0446X3yO5OuNAV9W51eq9O1On1bnWbV8_wueBl36O4df7qqAFuBXKWwwfR38v9TbwAgU6ZW</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Metwally, Fatehya M.</creator><creator>EL-mezayen, Hatem A.</creator><creator>Ahmed, Hanaa H.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Significance of vascular endothelial growth factor, interleukin-18 and nitric oxide in patients with breast cancer: correlation with carbohydrate antigen 15.3</title><author>Metwally, Fatehya M. ; EL-mezayen, Hatem A. ; Ahmed, Hanaa H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-48f50866fb21cd4d4d0196a71556f93ddaed24bb9e35ccee52350b05b29dee733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biomarkers, Tumor - blood</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Interleukin-18 - blood</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mucin-1 - blood</topic><topic>Nitric Oxide - blood</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Metwally, Fatehya M.</creatorcontrib><creatorcontrib>EL-mezayen, Hatem A.</creatorcontrib><creatorcontrib>Ahmed, Hanaa H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Metwally, Fatehya M.</au><au>EL-mezayen, Hatem A.</au><au>Ahmed, Hanaa H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of vascular endothelial growth factor, interleukin-18 and nitric oxide in patients with breast cancer: correlation with carbohydrate antigen 15.3</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>28</volume><issue>Suppl 1</issue><spage>15</spage><epage>21</epage><pages>15-21</pages><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>The aim of this study was to determine serum concentrations of angiogenic factors including vascular endothelial growth factor (VEGF), interleukin 18 (IL-18) and nitric oxide (NO) in patients with breast cancer and to evaluate whether these factors will be correlated with CA 15.3, as a routine tumor marker for breast cancer or not. This study was conducted on 44 patients with breast cancer and 15 healthy individuals as a control group. The results demonstrated significant increase in serum IL-18, NO and CA 15.3 levels in sera of breast cancer patients when compared to those of the control group (
P
< 0.001,
P
= 0.016 and
P
< 0.001, respectively). However, the mean serum level of VEGF in patients as showed insignificant increase compared to that of the controls was not significant (
P
= 0.311). Sensitivity of CA 15.3, VEGF, IL-18 and NO to detect patients with disease was 52.2, 21.3, 77.2 and 70.4 %, respectively. In addition, positive status of serum CA 15.3 and/or IL-18 was found in 39 out of 44 (88.6 %) patients, and the positive status of serum CA 15.3 and/or NO was only found in 35 out of 44 (79.5 %). In conclusion, the simultaneous determination of IL-18 or NO in combination with the CA 15.3 may increase the sensitivity to diagnose breast cancer and may aid in disease prognosis.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>20725807</pmid><doi>10.1007/s12032-010-9657-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1357-0560 |
| ispartof | Medical oncology (Northwood, London, England), 2011-12, Vol.28 (Suppl 1), p.15-21 |
| issn | 1357-0560 1559-131X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_913719834 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Biomarkers, Tumor - blood Breast cancer Breast Neoplasms - blood Breast Neoplasms - diagnosis Case-Control Studies Female Hematology Humans Interleukin-18 - blood Internal Medicine Medicine Medicine & Public Health Middle Aged Mucin-1 - blood Nitric Oxide - blood Oncology Original Paper Pathology Vascular Endothelial Growth Factor A - blood Young Adult |
| title | Significance of vascular endothelial growth factor, interleukin-18 and nitric oxide in patients with breast cancer: correlation with carbohydrate antigen 15.3 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T23%3A58%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Significance%20of%20vascular%20endothelial%20growth%20factor,%20interleukin-18%20and%20nitric%20oxide%20in%20patients%20with%20breast%20cancer:%20correlation%20with%20carbohydrate%20antigen%2015.3&rft.jtitle=Medical%20oncology%20(Northwood,%20London,%20England)&rft.au=Metwally,%20Fatehya%20M.&rft.date=2011-12-01&rft.volume=28&rft.issue=Suppl%201&rft.spage=15&rft.epage=21&rft.pages=15-21&rft.issn=1357-0560&rft.eissn=1559-131X&rft.coden=MONCEZ&rft_id=info:doi/10.1007/s12032-010-9657-2&rft_dat=%3Cproquest_cross%3E913719834%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=912298497&rft_id=info:pmid/20725807&rfr_iscdi=true |