Variations in thermal physiology and energetics of the tree shrew (Tupaia belangeri) in response to cold acclimation
Variations in environmental factors instigate significant changes in the physiology and behavior of animals, necessary for their survival. The present study investigated the hypothesis that ambient temperature is a cue capable of inducing changes in body mass, energy intake, and thermogenic capacity...
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| Veröffentlicht in: | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology Biochemical, systemic, and environmental physiology, 2012-01, Vol.182 (1), p.167-176 |
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| creator | Zhang, Lin Liu, Peng-fei Zhu, Wan-long Cai, Jin-hong Wang, Zheng-kun |
| description | Variations in environmental factors instigate significant changes in the physiology and behavior of animals, necessary for their survival. The present study investigated the hypothesis that ambient temperature is a cue capable of inducing changes in body mass, energy intake, and thermogenic capacity. Moreover, the current study determined the potential role of leptin in regulating adaptive thermogenesis in tree shrews (
Tupaia belangeri
). The tree shrew was chosen as the experimental animal as they inhabit a wide area of Asia and must acclimatize to the cold. Animals were subjected to either 5°C over 28 days to simulate cold acclimation, or maintained under the original climate of room temperature. At 28 days cold-acclimatized shrews had increased body mass by 9.41 g compared to controls. The increase in body mass was found primarily to be due to growth of the digestive organs, combined with significantly increased food intake. Under cold acclimation, uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT) was significantly elevated, while serum leptin concentration was significantly depressed below control levels. Serum leptin concentration was negatively correlated with body mass, energy intake, and thermogenic capacity during cold acclimation. In summary, these findings indicate that tree shrews adjust energy intake, thermogenic capacity, and body reserves in response to the cold, and further suggest that circulating leptin may act as a key signaling protein to regulate these adaptations. |
| doi_str_mv | 10.1007/s00360-011-0606-y |
| format | Article |
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Tupaia belangeri
). The tree shrew was chosen as the experimental animal as they inhabit a wide area of Asia and must acclimatize to the cold. Animals were subjected to either 5°C over 28 days to simulate cold acclimation, or maintained under the original climate of room temperature. At 28 days cold-acclimatized shrews had increased body mass by 9.41 g compared to controls. The increase in body mass was found primarily to be due to growth of the digestive organs, combined with significantly increased food intake. Under cold acclimation, uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT) was significantly elevated, while serum leptin concentration was significantly depressed below control levels. Serum leptin concentration was negatively correlated with body mass, energy intake, and thermogenic capacity during cold acclimation. In summary, these findings indicate that tree shrews adjust energy intake, thermogenic capacity, and body reserves in response to the cold, and further suggest that circulating leptin may act as a key signaling protein to regulate these adaptations.</description><identifier>ISSN: 0174-1578</identifier><identifier>EISSN: 1432-136X</identifier><identifier>DOI: 10.1007/s00360-011-0606-y</identifier><identifier>PMID: 21842263</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Acclimatization ; Acclimatization - physiology ; Adaptation, Physiological - physiology ; Adipose tissue ; Adipose Tissue, Brown - metabolism ; Ambient temperature ; Animal behavior ; Animal Physiology ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Body fat ; Body mass ; Body Weight - physiology ; Cold ; Cold Temperature ; Eating - physiology ; Energy consumption ; Energy Intake ; Environmental factors ; Female ; Food ; Human Physiology ; Humidity ; Hypotheses ; Ion Channels - metabolism ; Leptin - blood ; Leptin - metabolism ; Life Sciences ; Male ; Metabolism ; Mitochondrial Proteins - metabolism ; Original Paper ; Physiology ; Proteins ; Small mammals ; Temperature ; Thermogenesis ; Thermogenesis - physiology ; Tupaia - physiology ; Uncoupling Protein 1 ; Zoology</subject><ispartof>Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2012-01, Vol.182 (1), p.167-176</ispartof><rights>Springer-Verlag 2011</rights><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-74507a5721d6f2ea0706d9dcc84e89d296c7f11e037eef34a3ded6e6116b451d3</citedby><cites>FETCH-LOGICAL-c436t-74507a5721d6f2ea0706d9dcc84e89d296c7f11e037eef34a3ded6e6116b451d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00360-011-0606-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00360-011-0606-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21842263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Liu, Peng-fei</creatorcontrib><creatorcontrib>Zhu, Wan-long</creatorcontrib><creatorcontrib>Cai, Jin-hong</creatorcontrib><creatorcontrib>Wang, Zheng-kun</creatorcontrib><title>Variations in thermal physiology and energetics of the tree shrew (Tupaia belangeri) in response to cold acclimation</title><title>Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology</title><addtitle>J Comp Physiol B</addtitle><addtitle>J Comp Physiol B</addtitle><description>Variations in environmental factors instigate significant changes in the physiology and behavior of animals, necessary for their survival. The present study investigated the hypothesis that ambient temperature is a cue capable of inducing changes in body mass, energy intake, and thermogenic capacity. Moreover, the current study determined the potential role of leptin in regulating adaptive thermogenesis in tree shrews (
Tupaia belangeri
). The tree shrew was chosen as the experimental animal as they inhabit a wide area of Asia and must acclimatize to the cold. Animals were subjected to either 5°C over 28 days to simulate cold acclimation, or maintained under the original climate of room temperature. At 28 days cold-acclimatized shrews had increased body mass by 9.41 g compared to controls. The increase in body mass was found primarily to be due to growth of the digestive organs, combined with significantly increased food intake. Under cold acclimation, uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT) was significantly elevated, while serum leptin concentration was significantly depressed below control levels. Serum leptin concentration was negatively correlated with body mass, energy intake, and thermogenic capacity during cold acclimation. In summary, these findings indicate that tree shrews adjust energy intake, thermogenic capacity, and body reserves in response to the cold, and further suggest that circulating leptin may act as a key signaling protein to regulate these adaptations.</description><subject>Acclimatization</subject><subject>Acclimatization - physiology</subject><subject>Adaptation, Physiological - physiology</subject><subject>Adipose tissue</subject><subject>Adipose Tissue, Brown - metabolism</subject><subject>Ambient temperature</subject><subject>Animal behavior</subject><subject>Animal Physiology</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body fat</subject><subject>Body mass</subject><subject>Body Weight - physiology</subject><subject>Cold</subject><subject>Cold Temperature</subject><subject>Eating - physiology</subject><subject>Energy consumption</subject><subject>Energy Intake</subject><subject>Environmental factors</subject><subject>Female</subject><subject>Food</subject><subject>Human Physiology</subject><subject>Humidity</subject><subject>Hypotheses</subject><subject>Ion Channels - metabolism</subject><subject>Leptin - blood</subject><subject>Leptin - metabolism</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Metabolism</subject><subject>Mitochondrial Proteins - metabolism</subject><subject>Original Paper</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Small mammals</subject><subject>Temperature</subject><subject>Thermogenesis</subject><subject>Thermogenesis - physiology</subject><subject>Tupaia - physiology</subject><subject>Uncoupling Protein 1</subject><subject>Zoology</subject><issn>0174-1578</issn><issn>1432-136X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1v1DAQhi0EotvCD-CCLC6UQ8pM7LWzx6rio1KlXgriZnntya6rbBzsRCj_vk63gITEaQ5-5p0ZP4y9QbhAAP0xAwgFFSBWoEBV8zO2QinqCoX68ZytALWscK2bE3aa8z0ASGzkS3ZSl1LXSqzY-N2mYMcQ-8xDz8c9pYPt-LCfc4hd3M3c9p5TT2lHY3CZx3aB-JiIeN4n-sXP76bBBsu31Nl-Ryl8WJIS5aGEFjJyFzvPrXNdODyOesVetLbL9PqpnrFvnz_dXX2tbm6_XF9d3lROCjVWWq5B27Wu0au2JgsalN945xpJzcbXG-V0i0ggNFErpBWevCKFqLZyjV6csffH3CHFnxPl0RxCdtSVPSlO2WxQSIla1YV89w95H6fUl-UWCLVoHiE8Qi7FnBO1ZkjlojQbBLMIMUchpggxixAzl563T8HT9kD-T8dvAwWoj0AuT8v3_Z38_9QHKwaXOw</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Zhang, Lin</creator><creator>Liu, Peng-fei</creator><creator>Zhu, Wan-long</creator><creator>Cai, Jin-hong</creator><creator>Wang, Zheng-kun</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>7X8</scope></search><sort><creationdate>20120101</creationdate><title>Variations in thermal physiology and energetics of the tree shrew (Tupaia belangeri) in response to cold acclimation</title><author>Zhang, Lin ; Liu, Peng-fei ; Zhu, Wan-long ; Cai, Jin-hong ; Wang, Zheng-kun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-74507a5721d6f2ea0706d9dcc84e89d296c7f11e037eef34a3ded6e6116b451d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acclimatization</topic><topic>Acclimatization - physiology</topic><topic>Adaptation, Physiological - physiology</topic><topic>Adipose tissue</topic><topic>Adipose Tissue, Brown - metabolism</topic><topic>Ambient temperature</topic><topic>Animal behavior</topic><topic>Animal Physiology</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body fat</topic><topic>Body mass</topic><topic>Body Weight - physiology</topic><topic>Cold</topic><topic>Cold Temperature</topic><topic>Eating - physiology</topic><topic>Energy consumption</topic><topic>Energy Intake</topic><topic>Environmental factors</topic><topic>Female</topic><topic>Food</topic><topic>Human Physiology</topic><topic>Humidity</topic><topic>Hypotheses</topic><topic>Ion Channels - metabolism</topic><topic>Leptin - blood</topic><topic>Leptin - metabolism</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Metabolism</topic><topic>Mitochondrial Proteins - metabolism</topic><topic>Original Paper</topic><topic>Physiology</topic><topic>Proteins</topic><topic>Small mammals</topic><topic>Temperature</topic><topic>Thermogenesis</topic><topic>Thermogenesis - physiology</topic><topic>Tupaia - physiology</topic><topic>Uncoupling Protein 1</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Liu, Peng-fei</creatorcontrib><creatorcontrib>Zhu, Wan-long</creatorcontrib><creatorcontrib>Cai, Jin-hong</creatorcontrib><creatorcontrib>Wang, Zheng-kun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Lin</au><au>Liu, Peng-fei</au><au>Zhu, Wan-long</au><au>Cai, Jin-hong</au><au>Wang, Zheng-kun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variations in thermal physiology and energetics of the tree shrew (Tupaia belangeri) in response to cold acclimation</atitle><jtitle>Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology</jtitle><stitle>J Comp Physiol B</stitle><addtitle>J Comp Physiol B</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>182</volume><issue>1</issue><spage>167</spage><epage>176</epage><pages>167-176</pages><issn>0174-1578</issn><eissn>1432-136X</eissn><abstract>Variations in environmental factors instigate significant changes in the physiology and behavior of animals, necessary for their survival. The present study investigated the hypothesis that ambient temperature is a cue capable of inducing changes in body mass, energy intake, and thermogenic capacity. Moreover, the current study determined the potential role of leptin in regulating adaptive thermogenesis in tree shrews (
Tupaia belangeri
). The tree shrew was chosen as the experimental animal as they inhabit a wide area of Asia and must acclimatize to the cold. Animals were subjected to either 5°C over 28 days to simulate cold acclimation, or maintained under the original climate of room temperature. At 28 days cold-acclimatized shrews had increased body mass by 9.41 g compared to controls. The increase in body mass was found primarily to be due to growth of the digestive organs, combined with significantly increased food intake. Under cold acclimation, uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT) was significantly elevated, while serum leptin concentration was significantly depressed below control levels. Serum leptin concentration was negatively correlated with body mass, energy intake, and thermogenic capacity during cold acclimation. In summary, these findings indicate that tree shrews adjust energy intake, thermogenic capacity, and body reserves in response to the cold, and further suggest that circulating leptin may act as a key signaling protein to regulate these adaptations.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21842263</pmid><doi>10.1007/s00360-011-0606-y</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2012-01, Vol.182 (1), p.167-176 |
| issn | 0174-1578 1432-136X |
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| subjects | Acclimatization Acclimatization - physiology Adaptation, Physiological - physiology Adipose tissue Adipose Tissue, Brown - metabolism Ambient temperature Animal behavior Animal Physiology Animals Biochemistry Biomedical and Life Sciences Biomedicine Body fat Body mass Body Weight - physiology Cold Cold Temperature Eating - physiology Energy consumption Energy Intake Environmental factors Female Food Human Physiology Humidity Hypotheses Ion Channels - metabolism Leptin - blood Leptin - metabolism Life Sciences Male Metabolism Mitochondrial Proteins - metabolism Original Paper Physiology Proteins Small mammals Temperature Thermogenesis Thermogenesis - physiology Tupaia - physiology Uncoupling Protein 1 Zoology |
| title | Variations in thermal physiology and energetics of the tree shrew (Tupaia belangeri) in response to cold acclimation |
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