Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis
To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive 'lone' hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage. Sera were obtained from a total of 99 pa...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2011-11, Vol.29 (6), p.1006-1009 |
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| creator | DOLZANI, P ASSIRELLI, E PULSATELLI, L ADDIMANDA, O MANCARELLA, L PERI, G MANTOVANI, A FACCHINI, A MELICONI, R |
| description | To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive 'lone' hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage.
Sera were obtained from a total of 99 patients with HOA (52 patients with erosive HOA and 47 patients with non-erosive HOA) and from 50 control subjects (NC). Hand radiographs were obtained from all patients and scored for joint damage according to the Kellgren-Lawrence and the Kallman scores. Serum levels of high-sensitivity CRP (hsCRP), IL-6, pentraxin-3 (PTX-3), anti-CCP and anti-modified citrullinated vimentin (MCV) antibodies were evaluated by a sandwich ELISA.
Circulating levels of inflammatory biomarkers hsCRP, IL-6 and PTX3 were not significantly different in the two groups of patients with erosive and non-erosive HOA compared to NC and no significant difference was seen between non-erosive and erosive HOA. Anti-CCP positivity was detected respectively in 1 patient (2.1%) with non-erosive HOA and 1 patient (1.9%) with erosive HOA. Anti-MCV antibodies were present in 4 patients (8.5%) with non-erosive HOA, and 4 patients (7.7%) with erosive HOA. In the control group, one subject (2%) was positive for anti-CCP and 2 subjects (4%) had anti-MCV antibodies. Significant correlation was obtained only between body mass index and hsCRP concentration (r=0.4071; p |
| format | Article |
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Sera were obtained from a total of 99 patients with HOA (52 patients with erosive HOA and 47 patients with non-erosive HOA) and from 50 control subjects (NC). Hand radiographs were obtained from all patients and scored for joint damage according to the Kellgren-Lawrence and the Kallman scores. Serum levels of high-sensitivity CRP (hsCRP), IL-6, pentraxin-3 (PTX-3), anti-CCP and anti-modified citrullinated vimentin (MCV) antibodies were evaluated by a sandwich ELISA.
Circulating levels of inflammatory biomarkers hsCRP, IL-6 and PTX3 were not significantly different in the two groups of patients with erosive and non-erosive HOA compared to NC and no significant difference was seen between non-erosive and erosive HOA. Anti-CCP positivity was detected respectively in 1 patient (2.1%) with non-erosive HOA and 1 patient (1.9%) with erosive HOA. Anti-MCV antibodies were present in 4 patients (8.5%) with non-erosive HOA, and 4 patients (7.7%) with erosive HOA. In the control group, one subject (2%) was positive for anti-CCP and 2 subjects (4%) had anti-MCV antibodies. Significant correlation was obtained only between body mass index and hsCRP concentration (r=0.4071; p<0.0001). No correlation between inflammation markers/autoantibodies and disease duration and radiological scores was found.
Our study underlines the lack of systemic inflammation and autoimmunity in 'lone' HOA and confirms the association between BMI and CRP levels.</description><identifier>ISSN: 0392-856X</identifier><identifier>EISSN: 1593-098X</identifier><identifier>PMID: 22032420</identifier><language>eng</language><publisher>Pisa: Clinical and Experimental Rheumatology</publisher><subject>Aged ; Aged, 80 and over ; Autoimmunity ; Biological and medical sciences ; Biomarkers - blood ; C-Reactive Protein - analysis ; Diseases of the osteoarticular system ; Female ; Hand Joints - diagnostic imaging ; Hand Joints - pathology ; Humans ; Inflammation - blood ; Inflammation - diagnostic imaging ; Inflammation - pathology ; Interleukin-6 - blood ; Male ; Medical sciences ; Middle Aged ; Miscellaneous. Osteoarticular involvement in other diseases ; Osteoarthritis ; Osteoarthritis - blood ; Osteoarthritis - diagnosis ; Osteoarthritis - diagnostic imaging ; Peptides, Cyclic - immunology ; Radiography ; Serum Amyloid P-Component - analysis</subject><ispartof>Clinical and experimental rheumatology, 2011-11, Vol.29 (6), p.1006-1009</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25482539$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22032420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DOLZANI, P</creatorcontrib><creatorcontrib>ASSIRELLI, E</creatorcontrib><creatorcontrib>PULSATELLI, L</creatorcontrib><creatorcontrib>ADDIMANDA, O</creatorcontrib><creatorcontrib>MANCARELLA, L</creatorcontrib><creatorcontrib>PERI, G</creatorcontrib><creatorcontrib>MANTOVANI, A</creatorcontrib><creatorcontrib>FACCHINI, A</creatorcontrib><creatorcontrib>MELICONI, R</creatorcontrib><title>Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description>To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive 'lone' hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage.
Sera were obtained from a total of 99 patients with HOA (52 patients with erosive HOA and 47 patients with non-erosive HOA) and from 50 control subjects (NC). Hand radiographs were obtained from all patients and scored for joint damage according to the Kellgren-Lawrence and the Kallman scores. Serum levels of high-sensitivity CRP (hsCRP), IL-6, pentraxin-3 (PTX-3), anti-CCP and anti-modified citrullinated vimentin (MCV) antibodies were evaluated by a sandwich ELISA.
Circulating levels of inflammatory biomarkers hsCRP, IL-6 and PTX3 were not significantly different in the two groups of patients with erosive and non-erosive HOA compared to NC and no significant difference was seen between non-erosive and erosive HOA. Anti-CCP positivity was detected respectively in 1 patient (2.1%) with non-erosive HOA and 1 patient (1.9%) with erosive HOA. Anti-MCV antibodies were present in 4 patients (8.5%) with non-erosive HOA, and 4 patients (7.7%) with erosive HOA. In the control group, one subject (2%) was positive for anti-CCP and 2 subjects (4%) had anti-MCV antibodies. Significant correlation was obtained only between body mass index and hsCRP concentration (r=0.4071; p<0.0001). No correlation between inflammation markers/autoantibodies and disease duration and radiological scores was found.
Our study underlines the lack of systemic inflammation and autoimmunity in 'lone' HOA and confirms the association between BMI and CRP levels.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autoimmunity</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Hand Joints - diagnostic imaging</subject><subject>Hand Joints - pathology</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Inflammation - diagnostic imaging</subject><subject>Inflammation - pathology</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - blood</subject><subject>Osteoarthritis - diagnosis</subject><subject>Osteoarthritis - diagnostic imaging</subject><subject>Peptides, Cyclic - immunology</subject><subject>Radiography</subject><subject>Serum Amyloid P-Component - analysis</subject><issn>0392-856X</issn><issn>1593-098X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0EtLxDAUBeAgijOO_gXpRlwV0iRNm6UMvmDAhQ7MrtzmwUTSpCbpYv69FSsuLmdxP87inKF1VQtaYtEeztEaU0HKtuaHFbpK6RNjwmveXKIVIZgSRvAa7d9PKevBysJ642AYINvgC_Bqvmz7oKxORQ6FtDlOzlkPWati1GO2av5YXxx_cJhbAsR8jDbbdI0uDLikb5bcoP3T48f2pdy9Pb9uH3blSBjOpeBEVIIxYH0roWJUUwHUVFQbJqisDJVAWtWIHisOupGMc2KUJI3EQDmjG3T_2zvG8DXplLvBJqmdA6_DlDpRUTZvgNtZ3i5y6getujHaAeKp-1tiBncLgCTBmQhe2vTvataSmgr6DS9daXs</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>DOLZANI, P</creator><creator>ASSIRELLI, E</creator><creator>PULSATELLI, L</creator><creator>ADDIMANDA, O</creator><creator>MANCARELLA, L</creator><creator>PERI, G</creator><creator>MANTOVANI, A</creator><creator>FACCHINI, A</creator><creator>MELICONI, R</creator><general>Clinical and Experimental Rheumatology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis</title><author>DOLZANI, P ; ASSIRELLI, E ; PULSATELLI, L ; ADDIMANDA, O ; MANCARELLA, L ; PERI, G ; MANTOVANI, A ; FACCHINI, A ; MELICONI, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p240t-96291944a4b8ca143e39a3f13ef493c1f3ca28d79b0d6ae7c4662fdc27c0a3643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autoimmunity</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Hand Joints - diagnostic imaging</topic><topic>Hand Joints - pathology</topic><topic>Humans</topic><topic>Inflammation - blood</topic><topic>Inflammation - diagnostic imaging</topic><topic>Inflammation - pathology</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - blood</topic><topic>Osteoarthritis - diagnosis</topic><topic>Osteoarthritis - diagnostic imaging</topic><topic>Peptides, Cyclic - immunology</topic><topic>Radiography</topic><topic>Serum Amyloid P-Component - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DOLZANI, P</creatorcontrib><creatorcontrib>ASSIRELLI, E</creatorcontrib><creatorcontrib>PULSATELLI, L</creatorcontrib><creatorcontrib>ADDIMANDA, O</creatorcontrib><creatorcontrib>MANCARELLA, L</creatorcontrib><creatorcontrib>PERI, G</creatorcontrib><creatorcontrib>MANTOVANI, A</creatorcontrib><creatorcontrib>FACCHINI, A</creatorcontrib><creatorcontrib>MELICONI, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DOLZANI, P</au><au>ASSIRELLI, E</au><au>PULSATELLI, L</au><au>ADDIMANDA, O</au><au>MANCARELLA, L</au><au>PERI, G</au><au>MANTOVANI, A</au><au>FACCHINI, A</au><au>MELICONI, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>29</volume><issue>6</issue><spage>1006</spage><epage>1009</epage><pages>1006-1009</pages><issn>0392-856X</issn><eissn>1593-098X</eissn><abstract>To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive 'lone' hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage.
Sera were obtained from a total of 99 patients with HOA (52 patients with erosive HOA and 47 patients with non-erosive HOA) and from 50 control subjects (NC). Hand radiographs were obtained from all patients and scored for joint damage according to the Kellgren-Lawrence and the Kallman scores. Serum levels of high-sensitivity CRP (hsCRP), IL-6, pentraxin-3 (PTX-3), anti-CCP and anti-modified citrullinated vimentin (MCV) antibodies were evaluated by a sandwich ELISA.
Circulating levels of inflammatory biomarkers hsCRP, IL-6 and PTX3 were not significantly different in the two groups of patients with erosive and non-erosive HOA compared to NC and no significant difference was seen between non-erosive and erosive HOA. Anti-CCP positivity was detected respectively in 1 patient (2.1%) with non-erosive HOA and 1 patient (1.9%) with erosive HOA. Anti-MCV antibodies were present in 4 patients (8.5%) with non-erosive HOA, and 4 patients (7.7%) with erosive HOA. In the control group, one subject (2%) was positive for anti-CCP and 2 subjects (4%) had anti-MCV antibodies. Significant correlation was obtained only between body mass index and hsCRP concentration (r=0.4071; p<0.0001). No correlation between inflammation markers/autoantibodies and disease duration and radiological scores was found.
Our study underlines the lack of systemic inflammation and autoimmunity in 'lone' HOA and confirms the association between BMI and CRP levels.</abstract><cop>Pisa</cop><pub>Clinical and Experimental Rheumatology</pub><pmid>22032420</pmid><tpages>4</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Autoimmunity Biological and medical sciences Biomarkers - blood C-Reactive Protein - analysis Diseases of the osteoarticular system Female Hand Joints - diagnostic imaging Hand Joints - pathology Humans Inflammation - blood Inflammation - diagnostic imaging Inflammation - pathology Interleukin-6 - blood Male Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Osteoarthritis Osteoarthritis - blood Osteoarthritis - diagnosis Osteoarthritis - diagnostic imaging Peptides, Cyclic - immunology Radiography Serum Amyloid P-Component - analysis |
| title | Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis |
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