Development of a bar adsorptive micro-extraction–large-volume injection–gas chromatography–mass spectrometric method for pharmaceuticals and personal care products in environmental water matrices
The combination of bar adsorptive micro-extraction using activated carbon (AC) and polystyrene–divinylbenzene copolymer (PS-DVB) sorbent phases, followed by liquid desorption and large-volume injection gas chromatography coupled to mass spectrometry, under selected ion monitoring mode acquisition, w...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2012, Vol.402 (3), p.1355-1364 |
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| creator | Neng, N. R. Nogueira, J. M. F. |
| description | The combination of bar adsorptive micro-extraction using activated carbon (AC) and polystyrene–divinylbenzene copolymer (PS-DVB) sorbent phases, followed by liquid desorption and large-volume injection gas chromatography coupled to mass spectrometry, under selected ion monitoring mode acquisition, was developed for the first time to monitor pharmaceutical and personal care products (PPCPs) in environmental water matrices. Assays performed on 25 mL water samples spiked (100 ng L
−1
) with caffeine, gemfibrozil, triclosan, propranolol, carbamazepine and diazepam, selected as model compounds, yielded recoveries ranging from 74% to 99% under optimised experimental conditions (equilibrium time, 16 h (1,000 rpm); matrix characteristics: pH 5, 5% NaCl for AC phase; LD: methanol/acetonitrile (1:1), 45 min). The analytical performance showed good precision (RSD 0.99), where the PS-DVB sorbent phase showed a much better efficiency. By using the standard addition methodology, the application of the present analytical approach on tap, ground, sea, estuary and wastewater samples allowed very good performance at the trace level. The proposed method proved to be a suitable sorption-based micro-extraction alternative for the analysis of priority pollutants with medium-polar to polar characteristics, showing to be easy to implement, reliable, sensitive and requiring a low sample volume to monitor PPCPs in water matrices. |
| doi_str_mv | 10.1007/s00216-011-5515-0 |
| format | Article |
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−1
) with caffeine, gemfibrozil, triclosan, propranolol, carbamazepine and diazepam, selected as model compounds, yielded recoveries ranging from 74% to 99% under optimised experimental conditions (equilibrium time, 16 h (1,000 rpm); matrix characteristics: pH 5, 5% NaCl for AC phase; LD: methanol/acetonitrile (1:1), 45 min). The analytical performance showed good precision (RSD < 18%), convenient detection limits (5–20 ng L
−1
) and excellent linear dynamic range (20–800 ng L
−1
) with remarkable determination coefficients (
r
2
> 0.99), where the PS-DVB sorbent phase showed a much better efficiency. By using the standard addition methodology, the application of the present analytical approach on tap, ground, sea, estuary and wastewater samples allowed very good performance at the trace level. The proposed method proved to be a suitable sorption-based micro-extraction alternative for the analysis of priority pollutants with medium-polar to polar characteristics, showing to be easy to implement, reliable, sensitive and requiring a low sample volume to monitor PPCPs in water matrices.</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-011-5515-0</identifier><identifier>PMID: 22076312</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adsorption ; Adsorptivity ; Analytical Chemistry ; Biochemistry ; Characterization and Evaluation of Materials ; Charcoal - chemistry ; Chemistry ; Chemistry and Materials Science ; Copolymers ; Cosmetics - analysis ; Food Science ; Gas chromatography ; Gas Chromatography-Mass Spectrometry - instrumentation ; Gas Chromatography-Mass Spectrometry - methods ; Laboratory Medicine ; Mass spectrometry ; Mathematical analysis ; Matrices ; Matrix methods ; Methods ; Monitoring/Environmental Analysis ; Monitors ; Original Paper ; Personal care industry ; Pharmaceutical Preparations - analysis ; Pharmaceuticals ; Phases ; Polystyrenes - chemistry ; Reproducibility of Results ; Sensitivity and Specificity ; Solid Phase Extraction - instrumentation ; Solid Phase Extraction - methods ; Sorbents ; Toiletries ; Water ; Water Pollutants, Chemical - analysis</subject><ispartof>Analytical and bioanalytical chemistry, 2012, Vol.402 (3), p.1355-1364</ispartof><rights>Springer-Verlag 2011</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-532eeea1f82f48ce7446e01d23956fe1c100835afb2a88b44d61745559d2fafd3</citedby><cites>FETCH-LOGICAL-c514t-532eeea1f82f48ce7446e01d23956fe1c100835afb2a88b44d61745559d2fafd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-011-5515-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-011-5515-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22076312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neng, N. R.</creatorcontrib><creatorcontrib>Nogueira, J. M. F.</creatorcontrib><title>Development of a bar adsorptive micro-extraction–large-volume injection–gas chromatography–mass spectrometric method for pharmaceuticals and personal care products in environmental water matrices</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>The combination of bar adsorptive micro-extraction using activated carbon (AC) and polystyrene–divinylbenzene copolymer (PS-DVB) sorbent phases, followed by liquid desorption and large-volume injection gas chromatography coupled to mass spectrometry, under selected ion monitoring mode acquisition, was developed for the first time to monitor pharmaceutical and personal care products (PPCPs) in environmental water matrices. Assays performed on 25 mL water samples spiked (100 ng L
−1
) with caffeine, gemfibrozil, triclosan, propranolol, carbamazepine and diazepam, selected as model compounds, yielded recoveries ranging from 74% to 99% under optimised experimental conditions (equilibrium time, 16 h (1,000 rpm); matrix characteristics: pH 5, 5% NaCl for AC phase; LD: methanol/acetonitrile (1:1), 45 min). The analytical performance showed good precision (RSD < 18%), convenient detection limits (5–20 ng L
−1
) and excellent linear dynamic range (20–800 ng L
−1
) with remarkable determination coefficients (
r
2
> 0.99), where the PS-DVB sorbent phase showed a much better efficiency. By using the standard addition methodology, the application of the present analytical approach on tap, ground, sea, estuary and wastewater samples allowed very good performance at the trace level. The proposed method proved to be a suitable sorption-based micro-extraction alternative for the analysis of priority pollutants with medium-polar to polar characteristics, showing to be easy to implement, reliable, sensitive and requiring a low sample volume to monitor PPCPs in water matrices.</description><subject>Adsorption</subject><subject>Adsorptivity</subject><subject>Analytical Chemistry</subject><subject>Biochemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Charcoal - chemistry</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Copolymers</subject><subject>Cosmetics - analysis</subject><subject>Food Science</subject><subject>Gas chromatography</subject><subject>Gas Chromatography-Mass Spectrometry - instrumentation</subject><subject>Gas Chromatography-Mass Spectrometry - methods</subject><subject>Laboratory Medicine</subject><subject>Mass spectrometry</subject><subject>Mathematical analysis</subject><subject>Matrices</subject><subject>Matrix methods</subject><subject>Methods</subject><subject>Monitoring/Environmental Analysis</subject><subject>Monitors</subject><subject>Original Paper</subject><subject>Personal care industry</subject><subject>Pharmaceutical Preparations - analysis</subject><subject>Pharmaceuticals</subject><subject>Phases</subject><subject>Polystyrenes - chemistry</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Solid Phase Extraction - instrumentation</subject><subject>Solid Phase Extraction - methods</subject><subject>Sorbents</subject><subject>Toiletries</subject><subject>Water</subject><subject>Water Pollutants, Chemical - analysis</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9u1DAQxiMEoqXwAFyQb3BJ8Th24j1W5a9UiQuco1lnvJtVEgc7WeiNd-CpeA2ehInS9tgiH8aa-c03I_vLspcgz0HK6m2SUkGZS4DcGDC5fJSdQgk2V6WRj-_uWp1kz1I6SAnGQvk0O1FKVmUB6jT7846O1IWxp2ESwQsUW4wCmxTiOLVHEn3rYsjp5xTRTW0Y_v763WHcUX4M3dyTaIcD3RZ2mITbx9DjFHYRx_01J3tMSaSRIS7QFFsnOOxDI3yIYtxj7NHRPLUOuyRwaMRIMYUBO-EwkhhjaGY3JZ4kaDi2MQzLslz-gRNFwcNYk9Lz7IlnBXpxE8-ybx_ef738lF99-fj58uIqdwb0lJtCERGCt8pr66jSuiQJjSo2pvQEjl_WFgb9VqG1W62bEiptjNk0yqNvirPs9arLi32fKU113yZHXYcDhTnVGyh0URmrmHxzL8m6ugJtpflfFMryYRQqsJU1qnoYlVYpsEW1qJ6v6A47qtvBh-XD-TTEDggD-ZbzF7qQoItCLQ2wNrA9Uork6zG2PcZrVq0Xd9arO2t2Z724s5bc8-pmn3nbU3PXcWtHBtQKJC4NO4r1IcyRrZDuUf0Hcc729Q</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Neng, N. R.</creator><creator>Nogueira, J. M. F.</creator><general>Springer-Verlag</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7TV</scope><scope>7UA</scope><scope>C1K</scope><scope>7SR</scope><scope>7SU</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Development of a bar adsorptive micro-extraction–large-volume injection–gas chromatography–mass spectrometric method for pharmaceuticals and personal care products in environmental water matrices</title><author>Neng, N. R. ; Nogueira, J. M. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-532eeea1f82f48ce7446e01d23956fe1c100835afb2a88b44d61745559d2fafd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adsorption</topic><topic>Adsorptivity</topic><topic>Analytical Chemistry</topic><topic>Biochemistry</topic><topic>Characterization and Evaluation of Materials</topic><topic>Charcoal - chemistry</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Copolymers</topic><topic>Cosmetics - analysis</topic><topic>Food Science</topic><topic>Gas chromatography</topic><topic>Gas Chromatography-Mass Spectrometry - instrumentation</topic><topic>Gas Chromatography-Mass Spectrometry - methods</topic><topic>Laboratory Medicine</topic><topic>Mass spectrometry</topic><topic>Mathematical analysis</topic><topic>Matrices</topic><topic>Matrix methods</topic><topic>Methods</topic><topic>Monitoring/Environmental Analysis</topic><topic>Monitors</topic><topic>Original Paper</topic><topic>Personal care industry</topic><topic>Pharmaceutical Preparations - analysis</topic><topic>Pharmaceuticals</topic><topic>Phases</topic><topic>Polystyrenes - chemistry</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Solid Phase Extraction - instrumentation</topic><topic>Solid Phase Extraction - methods</topic><topic>Sorbents</topic><topic>Toiletries</topic><topic>Water</topic><topic>Water Pollutants, Chemical - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neng, N. R.</creatorcontrib><creatorcontrib>Nogueira, J. M. 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R.</au><au>Nogueira, J. M. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a bar adsorptive micro-extraction–large-volume injection–gas chromatography–mass spectrometric method for pharmaceuticals and personal care products in environmental water matrices</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2012</date><risdate>2012</risdate><volume>402</volume><issue>3</issue><spage>1355</spage><epage>1364</epage><pages>1355-1364</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>The combination of bar adsorptive micro-extraction using activated carbon (AC) and polystyrene–divinylbenzene copolymer (PS-DVB) sorbent phases, followed by liquid desorption and large-volume injection gas chromatography coupled to mass spectrometry, under selected ion monitoring mode acquisition, was developed for the first time to monitor pharmaceutical and personal care products (PPCPs) in environmental water matrices. Assays performed on 25 mL water samples spiked (100 ng L
−1
) with caffeine, gemfibrozil, triclosan, propranolol, carbamazepine and diazepam, selected as model compounds, yielded recoveries ranging from 74% to 99% under optimised experimental conditions (equilibrium time, 16 h (1,000 rpm); matrix characteristics: pH 5, 5% NaCl for AC phase; LD: methanol/acetonitrile (1:1), 45 min). The analytical performance showed good precision (RSD < 18%), convenient detection limits (5–20 ng L
−1
) and excellent linear dynamic range (20–800 ng L
−1
) with remarkable determination coefficients (
r
2
> 0.99), where the PS-DVB sorbent phase showed a much better efficiency. By using the standard addition methodology, the application of the present analytical approach on tap, ground, sea, estuary and wastewater samples allowed very good performance at the trace level. The proposed method proved to be a suitable sorption-based micro-extraction alternative for the analysis of priority pollutants with medium-polar to polar characteristics, showing to be easy to implement, reliable, sensitive and requiring a low sample volume to monitor PPCPs in water matrices.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22076312</pmid><doi>10.1007/s00216-011-5515-0</doi><tpages>10</tpages></addata></record> |
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| subjects | Adsorption Adsorptivity Analytical Chemistry Biochemistry Characterization and Evaluation of Materials Charcoal - chemistry Chemistry Chemistry and Materials Science Copolymers Cosmetics - analysis Food Science Gas chromatography Gas Chromatography-Mass Spectrometry - instrumentation Gas Chromatography-Mass Spectrometry - methods Laboratory Medicine Mass spectrometry Mathematical analysis Matrices Matrix methods Methods Monitoring/Environmental Analysis Monitors Original Paper Personal care industry Pharmaceutical Preparations - analysis Pharmaceuticals Phases Polystyrenes - chemistry Reproducibility of Results Sensitivity and Specificity Solid Phase Extraction - instrumentation Solid Phase Extraction - methods Sorbents Toiletries Water Water Pollutants, Chemical - analysis |
| title | Development of a bar adsorptive micro-extraction–large-volume injection–gas chromatography–mass spectrometric method for pharmaceuticals and personal care products in environmental water matrices |
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