The bile steroid chenodeoxycholate is a potent antagonist at NMDA and GABA(A) receptors

The bile steroids (BS) cholic acid and chenodeoxycholic acid are produced in hepatocytes and in the brain. Nothing is known about neuronal actions of BS. Deficiency in a 27-hydroxylase enzyme coincides with reduced production of chenodeoxycholic acid (CDCA) and a relative increase in cholic acid in...

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Veröffentlicht in:	Neuroscience letters 2012-01, Vol.506 (2), p.322-326
Hauptverfasser:	Schubring, S R, Fleischer, W, Lin, J S, Haas, H L, Sergeeva, O A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Chenodeoxycholic Acid - metabolism Chenodeoxycholic Acid - pharmacology Excitatory Amino Acid Antagonists - metabolism Excitatory Amino Acid Antagonists - pharmacology GABA-A Receptor Antagonists - metabolism GABA-A Receptor Antagonists - pharmacology Hypothalamus - drug effects Hypothalamus - metabolism Mice Neurons - drug effects Neurons - metabolism Patch-Clamp Techniques Receptors, GABA-A - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism
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