High-Mobility Group Box-1 and Its Receptors Contribute to Proinflammatory Response in the Acute Phase of Spinal Cord Injury in Rats

To examine the localization and expression of high-mobility group box-1 (HMGB-1) protein and its receptors after rat spinal cord injury. To elucidate the contribution of HMGB-1 and its receptors as potential candidates in a specific upstream pathway to the proinflammatory response leading to a casca...

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Veröffentlicht in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 2011-12, Vol.36 (25), p.2122-2129
Hauptverfasser:	CHEN, Ke-Bing, UCHIDA, Kenzo, BABA, Hisatoshi, NAKAJIMA, Hideaki, YAYAMA, Takafumi, HIRAI, Takayuki, RODRIGUEZ GUERRERO, Alexander, KOBAYASHI, Shigeru, MA, Wei-Ying, LIU, Shao-Yu, PING ZHU
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Reaction - etiology Acute-Phase Reaction - metabolism Animals Anterior Horn Cells - metabolism Anterior Horn Cells - ultrastructure Biological and medical sciences Cerebrospinal fluid. Meninges. Spinal cord Cytokines - metabolism Fluorescent Antibody Technique HMGB1 Protein - metabolism Immunoblotting Immunohistochemistry Inflammation Mediators - metabolism Injuries of the nervous system and the skull. Diseases due to physical agents Interleukin-1 - metabolism Interleukin-6 - metabolism Macrophages - metabolism Medical sciences Microscopy, Immunoelectron Nervous system (semeiology, syndromes) Neurology Neurons - metabolism Protein Binding Rats Receptor for Advanced Glycation End Products Receptors, Immunologic - metabolism Spinal Cord Injuries - complications Spinal Cord Injuries - metabolism Time Factors Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - metabolism Traumas. Diseases due to physical agents Tumor Necrosis Factor-alpha - metabolism
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