Origin and evolution of TNF and TNF receptor superfamilies

The tumor necrosis factor superfamily (TNFSF) and the TNF receptor superfamily (TNFRSF) have an ancient evolutionary origin that can be traced back to single copy genes within Arthropods. In humans, 18 TNFSF and 29 TNFRSF genes have been identified. Evolutionary models account for the increase in ge...

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Veröffentlicht in:	Developmental and comparative immunology 2011-12, Vol.35 (12), p.1324-1335
Hauptverfasser:	Wiens, Gregory D., Glenney, Gavin W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthropoda Biological Evolution Computational Biology Danio rerio Databases, Genetic Disease Resistance - immunology Evolution Expressed Sequence Tags Fishes - genetics Fishes - immunology Freshwater Gene Duplication Genome Genome duplication Humans Immunity, Innate Phylogeny Receptors, Tumor Necrosis Factor - chemistry Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - immunology Teleost Teleostei Tumor necrosis factor superfamily Tumor Necrosis Factors - chemistry Tumor Necrosis Factors - genetics Tumor Necrosis Factors - immunology Vertebrates - genetics Vertebrates - immunology
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