Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma

Huanming Yang, Zhiming Cai, Jun Wang and colleagues report whole-exome sequencing of 10 clear cell renal cell carcinomas followed by a screen of ~1,100 genes in a total of 98 tumors. They found 12 new disease-associated genes and detected frequent alterations in the ubiquitin-mediated proteolysis pa...

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Veröffentlicht in:	Nature genetics 2012-01, Vol.44 (1), p.17-19
Hauptverfasser:	Guo, Guangwu, Gui, Yaoting, Gao, Shengjie, Tang, Aifa, Hu, Xueda, Huang, Yi, Jia, Wenlong, Li, Zesong, He, Minghui, Sun, Liang, Song, Pengfei, Sun, Xiaojuan, Zhao, Xiaokun, Yang, Sangming, Liang, Chaozhao, Wan, Shengqing, Zhou, Fangjian, Chen, Chao, Zhu, Jialou, Li, Xianxin, Jian, Minghan, Zhou, Liang, Ye, Rui, Huang, Peide, Chen, Jing, Jiang, Tao, Liu, Xiao, Wang, Yong, Zou, Jing, Jiang, Zhimao, Wu, Renhua, Wu, Song, Fan, Fan, Zhang, Zhongfu, Liu, Lin, Yang, Ruilin, Liu, Xingwang, Wu, Haibo, Yin, Weihua, Zhao, Xia, Liu, Yuchen, Peng, Huanhuan, Jiang, Binghua, Feng, Qingxin, Li, Cailing, Xie, Jun, Lu, Jingxiao, Kristiansen, Karsten, Li, Yingrui, Zhang, Xiuqing, Li, Songgang, Wang, Jian, Yang, Huanming, Cai, Zhiming, Wang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/144/68 692/699/67/589/1588/1351 Agriculture Animal Genetics and Genomics Basic Helix-Loop-Helix Transcription Factors - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Cancer Research Carcinoma, Renal cell Carcinoma, Renal Cell - genetics Censuses Epigenetics Fundamental and applied biological sciences. Psychology Gene Function Gene mutations Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Health aspects Human Genetics Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Kidney Neoplasms - genetics Kidneys Medical sciences Methods Mutation Mutation Rate Nephrology. Urinary tract diseases Pathogenesis Physiological aspects Proteolysis Risk factors Signal Transduction Studies Tumors of the urinary system Ubiquitin Ubiquitination
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