A model for predicting size distributions delivered from pMDIs with suspended drug

A new model has been developed for predicting size distributions delivered from pressurized metered dose inhalers (pMDIs) that contain suspended drug particles. This model enables the residual particle size distribution to be predicted for a broad range of formulations. It expands on previous models...

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Bibliographische Detailangaben
Veröffentlicht in:	International journal of pharmaceutics 2012-01, Vol.422 (1), p.101-115
Hauptverfasser:	Stein, Stephen W., Sheth, Poonam, Myrdal, Paul B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerodynamic particle size Aerosols Albuterol - administration & dosage Albuterol - chemistry Bronchodilator Agents - administration & dosage Bronchodilator Agents - chemistry Chemistry, Pharmaceutical Drug Compounding Metered Dose Inhalers Models, Chemical Particle Size Pressurized metered dose inhaler (pMDI) Reproducibility of Results Simulation model Suspension formulation Technology, Pharmaceutical - methods
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