Anti-angiogenic therapy via cationic liposome-mediated systemic siRNA delivery

siRNA has been touted as a therapeutic molecule against genetic diseases, which include cancers. But several challenging issues remain in order to achieve efficient systemic siRNA delivery and a sufficient therapeutic effect for siRNA in vivo. Cationic liposome shows promise as a carrier for nucleic...

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Veröffentlicht in:	International journal of pharmaceutics 2012-01, Vol.422 (1), p.280-289
Hauptverfasser:	Tagami, Tatsuaki, Suzuki, Takuya, Matsunaga, Mariko, Nakamura, Kazuya, Moriyoshi, Naoto, Ishida, Tatsuhiro, Kiwada, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects air sacs Air Sacs - blood supply Animals Anti-angiogenic therapy Argonaute Proteins - genetics Argonaute Proteins - metabolism Argonaute2 (Ago2) blood vessels Carcinoma, Lewis Lung - blood supply Carcinoma, Lewis Lung - genetics Carcinoma, Lewis Lung - metabolism Carcinoma, Lewis Lung - pathology Carcinoma, Lewis Lung - therapy Cationic liposome Cations Cell Cycle Checkpoints Cell Proliferation Cholesterol - chemistry cytotoxicity Ethanolamines - chemistry genes genetic disorders Genetic Therapy - adverse effects Genetic Therapy - methods lipid composition Lipids - chemistry Lipids - toxicity Liposomes lung neoplasms Male Mice Myristates - chemistry Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control Neovascularization, Physiologic - genetics PEG-coated siRNA-lipoplex Phosphatidylcholines - chemistry Phosphatidylethanolamines - chemistry polyethylene glycol Polyethylene Glycols - chemistry RNA Interference RNA, Small Interfering - chemistry RNA, Small Interfering - metabolism RNA, Small Interfering - toxicity screening small interfering RNA Small interfering RNA (siRNA) therapeutics Time Factors Transfection Tumor Burden
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