Effect of sodium-channel blockade on early repolarization in inferior/lateral leads in patients with idiopathic ventricular fibrillation and Brugada syndrome
Background A high incidence of early repolarization (ER) pattern in the inferolateral leads has been reported in patients with idiopathic ventricular fibrillation (IVF). Brugada syndrome (BS) is characterized by J-point or ST-segment elevation in the right precordial leads and ventricular fibrillati...
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| creator | Kawata, Hiro, MD Noda, Takashi, MD, PhD Yamada, Yuko, MD Okamura, Hideo, MD Satomi, Kazuhiro, MD, PhD Aiba, Takeshi, MD, PhD Takaki, Hiroshi, MD Aihara, Naohiko, MD Isobe, Mitsuaki, MD, PhD Kamakura, Shiro, MD, PhD Shimizu, Wataru, MD, PhD |
| description | Background A high incidence of early repolarization (ER) pattern in the inferolateral leads has been reported in patients with idiopathic ventricular fibrillation (IVF). Brugada syndrome (BS) is characterized by J-point or ST-segment elevation in the right precordial leads and ventricular fibrillation, and some patients with BS also have ER in the inferolateral leads. Objective To compare the clinical characteristics and effects of sodium-channel blockade on ER between IVF patients with ER (early repolarization syndrome [ERS]) and BS patients with or without ER. Methods Fourteen patients with ERS and 21 patients with BS were included in this study. ER was defined as an elevation of at least 0.1 mV from baseline in the QRS–T junction in the inferorolateral leads. Provocative tests with sodium-channel blockers were conducted in all patients with ERS to distinguish ERS from BS. Results In the ERS group, all patients were male and most patients experienced ventricular fibrillation during sleep or low activity (79%). ER was attenuated by sodium-channel blockers in most patients with ERS (13/14, 93%) and BS (5/5, 100%), whereas ST-segment elevation was augmented in the right precordial leads in the BS group. The rates of positive late potentials were significantly higher in the BS group (60%) than in the ERS group (7%) ( P |
| doi_str_mv | 10.1016/j.hrthm.2011.08.017 |
| format | Article |
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Brugada syndrome (BS) is characterized by J-point or ST-segment elevation in the right precordial leads and ventricular fibrillation, and some patients with BS also have ER in the inferolateral leads. Objective To compare the clinical characteristics and effects of sodium-channel blockade on ER between IVF patients with ER (early repolarization syndrome [ERS]) and BS patients with or without ER. Methods Fourteen patients with ERS and 21 patients with BS were included in this study. ER was defined as an elevation of at least 0.1 mV from baseline in the QRS–T junction in the inferorolateral leads. Provocative tests with sodium-channel blockers were conducted in all patients with ERS to distinguish ERS from BS. Results In the ERS group, all patients were male and most patients experienced ventricular fibrillation during sleep or low activity (79%). ER was attenuated by sodium-channel blockers in most patients with ERS (13/14, 93%) and BS (5/5, 100%), whereas ST-segment elevation was augmented in the right precordial leads in the BS group. The rates of positive late potentials were significantly higher in the BS group (60%) than in the ERS group (7%) ( P <.01). Conclusions Some similarities were observed between ERS and BS, including gender, arrhythmia triggers, and response of ER to sodium-channel blockers. Unlike the ST segment in the right precordial leads in BS, ER was attenuated in patients with both ERS and BS, suggesting a differential mechanism between ER in the inferolateral leads and ST elevation in the right precordial leads.</description><identifier>ISSN: 1547-5271</identifier><identifier>EISSN: 1556-3871</identifier><identifier>DOI: 10.1016/j.hrthm.2011.08.017</identifier><identifier>PMID: 21855521</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Arrhythmias, Cardiac - drug therapy ; Arrhythmias, Cardiac - physiopathology ; Brugada syndrome ; Brugada Syndrome - drug therapy ; Brugada Syndrome - physiopathology ; Cardiovascular ; Early repolarization ; Electrocardiography - drug effects ; Humans ; Idiopathic ventricular fibrillation ; J wave ; Male ; Middle Aged ; Sodium Channel Blockers - pharmacology ; Sodium Channel Blockers - therapeutic use ; Sodium-channel blocker ; Sudden death ; Ventricular Fibrillation - drug therapy ; Ventricular Fibrillation - physiopathology</subject><ispartof>Heart rhythm, 2012, Vol.9 (1), p.77-83</ispartof><rights>Heart Rhythm Society</rights><rights>2012 Heart Rhythm Society</rights><rights>Copyright © 2012 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-988962a055f6fb7c433fba32ca74dc0bb8126e53a8e81b66835cdddb474ff0043</citedby><cites>FETCH-LOGICAL-c458t-988962a055f6fb7c433fba32ca74dc0bb8126e53a8e81b66835cdddb474ff0043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1547527111009465$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21855521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawata, Hiro, MD</creatorcontrib><creatorcontrib>Noda, Takashi, MD, PhD</creatorcontrib><creatorcontrib>Yamada, Yuko, MD</creatorcontrib><creatorcontrib>Okamura, Hideo, MD</creatorcontrib><creatorcontrib>Satomi, Kazuhiro, MD, PhD</creatorcontrib><creatorcontrib>Aiba, Takeshi, MD, PhD</creatorcontrib><creatorcontrib>Takaki, Hiroshi, MD</creatorcontrib><creatorcontrib>Aihara, Naohiko, MD</creatorcontrib><creatorcontrib>Isobe, Mitsuaki, MD, PhD</creatorcontrib><creatorcontrib>Kamakura, Shiro, MD, PhD</creatorcontrib><creatorcontrib>Shimizu, Wataru, MD, PhD</creatorcontrib><title>Effect of sodium-channel blockade on early repolarization in inferior/lateral leads in patients with idiopathic ventricular fibrillation and Brugada syndrome</title><title>Heart rhythm</title><addtitle>Heart Rhythm</addtitle><description>Background A high incidence of early repolarization (ER) pattern in the inferolateral leads has been reported in patients with idiopathic ventricular fibrillation (IVF). Brugada syndrome (BS) is characterized by J-point or ST-segment elevation in the right precordial leads and ventricular fibrillation, and some patients with BS also have ER in the inferolateral leads. Objective To compare the clinical characteristics and effects of sodium-channel blockade on ER between IVF patients with ER (early repolarization syndrome [ERS]) and BS patients with or without ER. Methods Fourteen patients with ERS and 21 patients with BS were included in this study. ER was defined as an elevation of at least 0.1 mV from baseline in the QRS–T junction in the inferorolateral leads. Provocative tests with sodium-channel blockers were conducted in all patients with ERS to distinguish ERS from BS. Results In the ERS group, all patients were male and most patients experienced ventricular fibrillation during sleep or low activity (79%). ER was attenuated by sodium-channel blockers in most patients with ERS (13/14, 93%) and BS (5/5, 100%), whereas ST-segment elevation was augmented in the right precordial leads in the BS group. The rates of positive late potentials were significantly higher in the BS group (60%) than in the ERS group (7%) ( P <.01). Conclusions Some similarities were observed between ERS and BS, including gender, arrhythmia triggers, and response of ER to sodium-channel blockers. Unlike the ST segment in the right precordial leads in BS, ER was attenuated in patients with both ERS and BS, suggesting a differential mechanism between ER in the inferolateral leads and ST elevation in the right precordial leads.</description><subject>Adult</subject><subject>Arrhythmias, Cardiac - drug therapy</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>Brugada syndrome</subject><subject>Brugada Syndrome - drug therapy</subject><subject>Brugada Syndrome - physiopathology</subject><subject>Cardiovascular</subject><subject>Early repolarization</subject><subject>Electrocardiography - drug effects</subject><subject>Humans</subject><subject>Idiopathic ventricular fibrillation</subject><subject>J wave</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Sodium Channel Blockers - pharmacology</subject><subject>Sodium Channel Blockers - therapeutic use</subject><subject>Sodium-channel blocker</subject><subject>Sudden death</subject><subject>Ventricular Fibrillation - drug therapy</subject><subject>Ventricular Fibrillation - physiopathology</subject><issn>1547-5271</issn><issn>1556-3871</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk2P1SAUbYzG-dBfYGLYuWqHj0LpQhNnMo4mk7hQ14TCxfKGlie0Y57_xf8q9Y0u3JiQQA7nnAv33Kp6QXBDMBEXu2ZMyzg1FBPSYNlg0j2qTgnnomayI4-3c9vVnHbkpDrLeYcx7QVmT6sTSiTnnJLT6ue1c2AWFB3K0fp1qs2o5xkCGkI0d9oCijMCncIBJdjHoJP_oRdfQL8tB8nHdBH0AkkHFEDbvN3sCwfmJaPvfhmRtz4WZPQG3Rc0ebMWI-T8kHwIRzs9W3SZ1q_aapQPs01xgmfVE6dDhucP-3n15d3156v39e3Hmw9Xb29r03K51L2UvaAac-6EGzrTMuYGzajRXWsNHgZJqADOtARJBiEk48ZaO7Rd6xzGLTuvXh199yl-WyEvavLZQHnaDHHNqidUYsE7WpjsyDQp5pzAqX3yk04HRbDaYlE79TsWtcWisFQllqJ6-eC_DhPYv5o_ORTC6yMByi_vPSSVTemfAetTiUfZ6P9T4M0_ehP87I0Od3CAvItrmksDFVGZKqw-bZOxDQYhGPet4OwXnEO4rQ</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Kawata, Hiro, MD</creator><creator>Noda, Takashi, MD, PhD</creator><creator>Yamada, Yuko, MD</creator><creator>Okamura, Hideo, MD</creator><creator>Satomi, Kazuhiro, MD, PhD</creator><creator>Aiba, Takeshi, MD, PhD</creator><creator>Takaki, Hiroshi, MD</creator><creator>Aihara, Naohiko, MD</creator><creator>Isobe, Mitsuaki, MD, PhD</creator><creator>Kamakura, Shiro, MD, PhD</creator><creator>Shimizu, Wataru, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Effect of sodium-channel blockade on early repolarization in inferior/lateral leads in patients with idiopathic ventricular fibrillation and Brugada syndrome</title><author>Kawata, Hiro, MD ; Noda, Takashi, MD, PhD ; Yamada, Yuko, MD ; Okamura, Hideo, MD ; Satomi, Kazuhiro, MD, PhD ; Aiba, Takeshi, MD, PhD ; Takaki, Hiroshi, MD ; Aihara, Naohiko, MD ; Isobe, Mitsuaki, MD, PhD ; Kamakura, Shiro, MD, PhD ; Shimizu, Wataru, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-988962a055f6fb7c433fba32ca74dc0bb8126e53a8e81b66835cdddb474ff0043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Arrhythmias, Cardiac - drug therapy</topic><topic>Arrhythmias, Cardiac - physiopathology</topic><topic>Brugada syndrome</topic><topic>Brugada Syndrome - drug therapy</topic><topic>Brugada Syndrome - physiopathology</topic><topic>Cardiovascular</topic><topic>Early repolarization</topic><topic>Electrocardiography - drug effects</topic><topic>Humans</topic><topic>Idiopathic ventricular fibrillation</topic><topic>J wave</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Sodium Channel Blockers - pharmacology</topic><topic>Sodium Channel Blockers - therapeutic use</topic><topic>Sodium-channel blocker</topic><topic>Sudden death</topic><topic>Ventricular Fibrillation - drug therapy</topic><topic>Ventricular Fibrillation - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawata, Hiro, MD</creatorcontrib><creatorcontrib>Noda, Takashi, MD, PhD</creatorcontrib><creatorcontrib>Yamada, Yuko, MD</creatorcontrib><creatorcontrib>Okamura, Hideo, MD</creatorcontrib><creatorcontrib>Satomi, Kazuhiro, MD, PhD</creatorcontrib><creatorcontrib>Aiba, Takeshi, MD, PhD</creatorcontrib><creatorcontrib>Takaki, Hiroshi, MD</creatorcontrib><creatorcontrib>Aihara, Naohiko, MD</creatorcontrib><creatorcontrib>Isobe, Mitsuaki, MD, PhD</creatorcontrib><creatorcontrib>Kamakura, Shiro, MD, PhD</creatorcontrib><creatorcontrib>Shimizu, Wataru, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Heart rhythm</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawata, Hiro, MD</au><au>Noda, Takashi, MD, PhD</au><au>Yamada, Yuko, MD</au><au>Okamura, Hideo, MD</au><au>Satomi, Kazuhiro, MD, PhD</au><au>Aiba, Takeshi, MD, PhD</au><au>Takaki, Hiroshi, MD</au><au>Aihara, Naohiko, MD</au><au>Isobe, Mitsuaki, MD, PhD</au><au>Kamakura, Shiro, MD, PhD</au><au>Shimizu, Wataru, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of sodium-channel blockade on early repolarization in inferior/lateral leads in patients with idiopathic ventricular fibrillation and Brugada syndrome</atitle><jtitle>Heart rhythm</jtitle><addtitle>Heart Rhythm</addtitle><date>2012</date><risdate>2012</risdate><volume>9</volume><issue>1</issue><spage>77</spage><epage>83</epage><pages>77-83</pages><issn>1547-5271</issn><eissn>1556-3871</eissn><abstract>Background A high incidence of early repolarization (ER) pattern in the inferolateral leads has been reported in patients with idiopathic ventricular fibrillation (IVF). Brugada syndrome (BS) is characterized by J-point or ST-segment elevation in the right precordial leads and ventricular fibrillation, and some patients with BS also have ER in the inferolateral leads. Objective To compare the clinical characteristics and effects of sodium-channel blockade on ER between IVF patients with ER (early repolarization syndrome [ERS]) and BS patients with or without ER. Methods Fourteen patients with ERS and 21 patients with BS were included in this study. ER was defined as an elevation of at least 0.1 mV from baseline in the QRS–T junction in the inferorolateral leads. Provocative tests with sodium-channel blockers were conducted in all patients with ERS to distinguish ERS from BS. Results In the ERS group, all patients were male and most patients experienced ventricular fibrillation during sleep or low activity (79%). ER was attenuated by sodium-channel blockers in most patients with ERS (13/14, 93%) and BS (5/5, 100%), whereas ST-segment elevation was augmented in the right precordial leads in the BS group. The rates of positive late potentials were significantly higher in the BS group (60%) than in the ERS group (7%) ( P <.01). Conclusions Some similarities were observed between ERS and BS, including gender, arrhythmia triggers, and response of ER to sodium-channel blockers. Unlike the ST segment in the right precordial leads in BS, ER was attenuated in patients with both ERS and BS, suggesting a differential mechanism between ER in the inferolateral leads and ST elevation in the right precordial leads.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21855521</pmid><doi>10.1016/j.hrthm.2011.08.017</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - physiopathology Brugada syndrome Brugada Syndrome - drug therapy Brugada Syndrome - physiopathology Cardiovascular Early repolarization Electrocardiography - drug effects Humans Idiopathic ventricular fibrillation J wave Male Middle Aged Sodium Channel Blockers - pharmacology Sodium Channel Blockers - therapeutic use Sodium-channel blocker Sudden death Ventricular Fibrillation - drug therapy Ventricular Fibrillation - physiopathology |
| title | Effect of sodium-channel blockade on early repolarization in inferior/lateral leads in patients with idiopathic ventricular fibrillation and Brugada syndrome |
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