Overexpressed HER2 in NSCLC is a Possible Therapeutic Target of EGFR Inhibitors

"Oncogene addiction" is a concept in which tumor cells exhibit dependence on certain oncogene(s) for their sustained proliferation and survival, thus providing the rationale for molecular targeted therapies. Cancer cells addicted to epidermal growth factor receptor (EGFR) bear activated mu...

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Veröffentlicht in:	Anticancer research 2011-12, Vol.31 (12), p.4155-4161
Hauptverfasser:	ISE, Nobuyuki, OMI, Kazuya, NAMBARA, Daisuke, HIGASHIYAMA, Shigeki, GOISHI, Katsutoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomarkers, Tumor Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Erlotinib Hydrochloride Humans Immunohistochemistry - methods Lung Neoplasms - metabolism Medical sciences Mice Mutation Neoplasm Transplantation Pneumology Quinazolines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, ErbB-2 - biosynthesis Treatment Outcome Tumors Tumors of the respiratory system and mediastinum
Online-Zugang:	Volltext
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