Analysis of molecular forms of urine Retinol-Binding Protein in Fanconi Syndrome and design of an accurate immunoassay

Retinol-Binding Protein in urine (uRBP), a biomarker for the proximal renal tubular disease of congenital and acquired Fanconi Syndrome (FS) occurs in multiple forms. However these have not had quantitative mass spectrometric (MS) analysis, nor is there a validated assay for defined molecular specie...

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Veröffentlicht in:	Clinica chimica acta 2012-02, Vol.413 (3), p.483-489
Hauptverfasser:	Burling, Keith A., Cutillas, Pedro R., Church, David, Lapsley, Marta, Norden, Anthony G.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Biotinylation Dissociation-enhanced lanthanide fluorescence immunoassay Fanconi Syndrome - genetics Fanconi Syndrome - urine Humans Immunoassay - methods Immunoassay - standards Limit of Detection Linear Models Prealbumin - metabolism Recombinant Proteins - blood Recombinant Proteins - metabolism Reference Values Renal Fanconi Syndrome Reproducibility of Results Retinol-Binding Protein Retinol-Binding Protein 4 Retinol-Binding Proteins - immunology Retinol-Binding Proteins - urine Retinol-Binding Proteins, Plasma - genetics Retinol-Binding Proteins, Plasma - metabolism Sensitivity and Specificity Sequence Deletion Tubular proteinuria Urinalysis - methods Urinalysis - standards ‘Top-down’ protein mass spectrometry
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