Myocardial G Protein Receptor–Coupled Kinase Expression Correlates With Functional Parameters and Clinical Severity in Advanced Heart Failure

Abstract Background In heart failure (HF), sympathetic hyperactivation induces deleterious effects in myocardial β-adrenergic signaling, with receptor down-regulation and desensitization mediated by G protein receptor–coupled kinases (GRKs). We hypothesised that changes in GRK isoforms may be associ...

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Veröffentlicht in:	Journal of cardiac failure 2012, Vol.18 (1), p.53-61
Hauptverfasser:	Agüero, Jaime, MD, Almenar, Luis, MD, PhD, Montó, FermÍ, MS, Oliver, Eduardo, PhD, Sánchez-Lázaro, Ignacio, MD, Vicente, Diana, MS, MartÍnez-Dolz, Luis, MD, PhD, D’Ocon, Pilar, PhD, Rueda, Joaquin, MD, PhD, Salvador, Antonio, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	adrenergic system Cardiovascular Down-Regulation Female G protein receptor kinase G-Protein-Coupled Receptor Kinase 2 - genetics G-Protein-Coupled Receptor Kinase 5 - genetics G-Protein-Coupled Receptor Kinases - chemistry G-Protein-Coupled Receptor Kinases - genetics G-Protein-Coupled Receptor Kinases - metabolism Gene Expression Regulation, Enzymologic genomics Heart Failure - enzymology Heart Failure - genetics Heart Failure - physiopathology Heart-Assist Devices Humans INTERMACS Male Middle Aged Myocardium - enzymology Polymerase Chain Reaction Registries RNA, Messenger - analysis Severity of Illness Index Spain
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