Paenibacillus polymyxa PKB1 Produces Variants of Polymyxin B-Type Antibiotics

Polymyxins are cationic lipopeptide antibiotics active against many species of Gram-negative bacteria. We sequenced the gene cluster for polymyxin biosynthesis from Paenibacillus polymyxa PKB1. The 40.8 kb gene cluster comprises three nonribosomal peptide synthetase-encoding genes and two ABC transp...

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Veröffentlicht in:	Chemistry & biology 2011-12, Vol.18 (12), p.1640-1648
Hauptverfasser:	Shaheen, Mohamed, Li, Jingru, Ross, Avena C., Vederas, John C., Jensen, Susan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Chromatography, High Pressure Liquid Gas Chromatography-Mass Spectrometry Molecular Sequence Data Multigene Family Paenibacillus - enzymology Paenibacillus - genetics Paenibacillus - metabolism Peptide Synthases - genetics Peptide Synthases - metabolism Polymyxins - analogs & derivatives Polymyxins - biosynthesis Polymyxins - chemistry Stereoisomerism Tandem Mass Spectrometry
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