Maternal Serum Alpha-Fetoprotein in Normal Pregnancy at 11–13 Weeks’ Gestation
Objective: To establish a reference distribution of maternal serum alpha-fetoprotein (AFP) at 11–13 weeks’ gestation and define the contribution of maternal variables that influence the measured concentration of AFP. Methods: Serum concentration of AFP at 11–13 weeks was measured in 1,500 singleton...
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| Veröffentlicht in: | Fetal diagnosis and therapy 2011-01, Vol.30 (4), p.274-279 |
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| creator | Bredaki, Foteini E. Wright, David Akolekar, Ranjit Cruz, Grasielle Nicolaides, Kypros H. |
| description | Objective: To establish a reference distribution of maternal serum alpha-fetoprotein (AFP) at 11–13 weeks’ gestation and define the contribution of maternal variables that influence the measured concentration of AFP. Methods: Serum concentration of AFP at 11–13 weeks was measured in 1,500 singleton pregnancies which were not complicated by hypertensive disorders or diabetes mellitus and resulted in the live birth at or after 37 weeks of phenotypically normal neonates with birth weights above the 5th and below the 95th percentile. Multiple regression analysis was used to account for maternal characteristics that influence the measured concentration of AFP and a distribution of log multiples of the median (MoM) values was fitted. Results: Log 10 AFP increased with gestational age, decreased with maternal weight and was significantly affected by maternal racial origin, smoking status and method of conception. Compared with values in Caucasian women who were non-smokers and conceived spontaneously, AFP MoM was on average 23% higher in Afro-Caribbeans and 8% lower in East Asians, 11% higher in smokers and 10% higher in those conceiving by in vitro fertilization. Conclusion: In normal pregnancies at 11–13 weeks, serum AFP increases with gestational age and is affected by maternal race, weight, smoking status and method of conception. |
| doi_str_mv | 10.1159/000330200 |
| format | Article |
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Methods: Serum concentration of AFP at 11–13 weeks was measured in 1,500 singleton pregnancies which were not complicated by hypertensive disorders or diabetes mellitus and resulted in the live birth at or after 37 weeks of phenotypically normal neonates with birth weights above the 5th and below the 95th percentile. Multiple regression analysis was used to account for maternal characteristics that influence the measured concentration of AFP and a distribution of log multiples of the median (MoM) values was fitted. Results: Log 10 AFP increased with gestational age, decreased with maternal weight and was significantly affected by maternal racial origin, smoking status and method of conception. Compared with values in Caucasian women who were non-smokers and conceived spontaneously, AFP MoM was on average 23% higher in Afro-Caribbeans and 8% lower in East Asians, 11% higher in smokers and 10% higher in those conceiving by in vitro fertilization. Conclusion: In normal pregnancies at 11–13 weeks, serum AFP increases with gestational age and is affected by maternal race, weight, smoking status and method of conception.</description><identifier>ISSN: 1015-3837</identifier><identifier>EISSN: 1421-9964</identifier><identifier>DOI: 10.1159/000330200</identifier><identifier>PMID: 22156386</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>alpha-Fetoproteins - metabolism ; Biological and medical sciences ; Delivery. Postpartum. Lactation ; Female ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Original Paper ; Pregnancy - blood ; Pregnancy Trimester, First - blood ; Regression Analysis ; Serum - chemistry</subject><ispartof>Fetal diagnosis and therapy, 2011-01, Vol.30 (4), p.274-279</ispartof><rights>2011 S. Karger AG, Basel</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-77e03c7b836f555b31ae5820db540b844097b28d8def9b21fb6243f6d3f57a463</citedby><cites>FETCH-LOGICAL-c362t-77e03c7b836f555b31ae5820db540b844097b28d8def9b21fb6243f6d3f57a463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25416929$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22156386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bredaki, Foteini E.</creatorcontrib><creatorcontrib>Wright, David</creatorcontrib><creatorcontrib>Akolekar, Ranjit</creatorcontrib><creatorcontrib>Cruz, Grasielle</creatorcontrib><creatorcontrib>Nicolaides, Kypros H.</creatorcontrib><title>Maternal Serum Alpha-Fetoprotein in Normal Pregnancy at 11–13 Weeks’ Gestation</title><title>Fetal diagnosis and therapy</title><addtitle>Fetal Diagn Ther</addtitle><description>Objective: To establish a reference distribution of maternal serum alpha-fetoprotein (AFP) at 11–13 weeks’ gestation and define the contribution of maternal variables that influence the measured concentration of AFP. Methods: Serum concentration of AFP at 11–13 weeks was measured in 1,500 singleton pregnancies which were not complicated by hypertensive disorders or diabetes mellitus and resulted in the live birth at or after 37 weeks of phenotypically normal neonates with birth weights above the 5th and below the 95th percentile. Multiple regression analysis was used to account for maternal characteristics that influence the measured concentration of AFP and a distribution of log multiples of the median (MoM) values was fitted. Results: Log 10 AFP increased with gestational age, decreased with maternal weight and was significantly affected by maternal racial origin, smoking status and method of conception. Compared with values in Caucasian women who were non-smokers and conceived spontaneously, AFP MoM was on average 23% higher in Afro-Caribbeans and 8% lower in East Asians, 11% higher in smokers and 10% higher in those conceiving by in vitro fertilization. Conclusion: In normal pregnancies at 11–13 weeks, serum AFP increases with gestational age and is affected by maternal race, weight, smoking status and method of conception.</description><subject>alpha-Fetoproteins - metabolism</subject><subject>Biological and medical sciences</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Female</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Original Paper</subject><subject>Pregnancy - blood</subject><subject>Pregnancy Trimester, First - blood</subject><subject>Regression Analysis</subject><subject>Serum - chemistry</subject><issn>1015-3837</issn><issn>1421-9964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0MtKw0AUBuBBFKvVhXuRIIi4iM49k2Uptgr1ghdchklyomlzqTPJoru-gytfr0_ilNYKwsCZxce5_AgdEXxJiAivMMaMYYrxFtojnBI_DCXfdn9MhM8UCzpo39qxYypgchd1KCVCMiX30NOdbsBUuvCewbSl1yumH9ofQFNPTd1AXnnu3demdOLRwHulq2Tm6cYjZDH_Isx7A5jYxfzbG4JtdJPX1QHayXRh4XBdu-h1cP3Sv_FHD8Pbfm_kJ0zSxg8CwCwJYsVkJoSIGdEgFMVpLDiOFec4DGKqUpVCFsaUZLGknGUyZZkINJesi85Xfd2mn62bHpW5TaAodAV1a6OQUMmppMrJ039yXLfLox2STBDKA-zQxQolprbWQBZNTV5qM4sIjpYxR5uYnT1ZN2zjEtKN_M3VgbM10DbRRWZcbLn9c4ITGdLQueOVm2jzDmYD1nN-AAFljBI</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Bredaki, Foteini E.</creator><creator>Wright, David</creator><creator>Akolekar, Ranjit</creator><creator>Cruz, Grasielle</creator><creator>Nicolaides, Kypros H.</creator><general>Karger</general><general>S. 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Postpartum. Lactation</topic><topic>Female</topic><topic>General aspects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Original Paper</topic><topic>Pregnancy - blood</topic><topic>Pregnancy Trimester, First - blood</topic><topic>Regression Analysis</topic><topic>Serum - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bredaki, Foteini E.</creatorcontrib><creatorcontrib>Wright, David</creatorcontrib><creatorcontrib>Akolekar, Ranjit</creatorcontrib><creatorcontrib>Cruz, Grasielle</creatorcontrib><creatorcontrib>Nicolaides, Kypros H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Fetal diagnosis and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bredaki, Foteini E.</au><au>Wright, David</au><au>Akolekar, Ranjit</au><au>Cruz, Grasielle</au><au>Nicolaides, Kypros H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal Serum Alpha-Fetoprotein in Normal Pregnancy at 11–13 Weeks’ Gestation</atitle><jtitle>Fetal diagnosis and therapy</jtitle><addtitle>Fetal Diagn Ther</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>30</volume><issue>4</issue><spage>274</spage><epage>279</epage><pages>274-279</pages><issn>1015-3837</issn><eissn>1421-9964</eissn><abstract>Objective: To establish a reference distribution of maternal serum alpha-fetoprotein (AFP) at 11–13 weeks’ gestation and define the contribution of maternal variables that influence the measured concentration of AFP. Methods: Serum concentration of AFP at 11–13 weeks was measured in 1,500 singleton pregnancies which were not complicated by hypertensive disorders or diabetes mellitus and resulted in the live birth at or after 37 weeks of phenotypically normal neonates with birth weights above the 5th and below the 95th percentile. Multiple regression analysis was used to account for maternal characteristics that influence the measured concentration of AFP and a distribution of log multiples of the median (MoM) values was fitted. Results: Log 10 AFP increased with gestational age, decreased with maternal weight and was significantly affected by maternal racial origin, smoking status and method of conception. Compared with values in Caucasian women who were non-smokers and conceived spontaneously, AFP MoM was on average 23% higher in Afro-Caribbeans and 8% lower in East Asians, 11% higher in smokers and 10% higher in those conceiving by in vitro fertilization. Conclusion: In normal pregnancies at 11–13 weeks, serum AFP increases with gestational age and is affected by maternal race, weight, smoking status and method of conception.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>22156386</pmid><doi>10.1159/000330200</doi><tpages>6</tpages></addata></record> |
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| ispartof | Fetal diagnosis and therapy, 2011-01, Vol.30 (4), p.274-279 |
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| subjects | alpha-Fetoproteins - metabolism Biological and medical sciences Delivery. Postpartum. Lactation Female General aspects Gynecology. Andrology. Obstetrics Humans Medical sciences Original Paper Pregnancy - blood Pregnancy Trimester, First - blood Regression Analysis Serum - chemistry |
| title | Maternal Serum Alpha-Fetoprotein in Normal Pregnancy at 11–13 Weeks’ Gestation |
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