Constitutive Activation of IKKβ in Adipose Tissue Prevents Diet-Induced Obesity in Mice

The IκB kinase β (IKKβ) is a master kinase involved in obesity-related inflammation and insulin resistance through nuclear factor κB dependent and independent pathways. However, the effect of IKKβ activation in adipose tissue, the organ critical for storage of excessive energy and initiation of infl...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2012-01, Vol.153 (1), p.154-165
Hauptverfasser:	Jiao, Ping, Feng, Bin, Ma, Jie, Nie, Yaohui, Paul, Erin, Li, Yujie, Xu, Haiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipose tissue Adipose Tissue - enzymology Adipose Tissue - pathology Age Animals Biological and medical sciences Blood levels Body fat Body Weight Body weight gain Diet Diet, High-Fat - adverse effects Eating Energy expenditure Energy Metabolism Enzyme Activation Fatty acid-binding protein Fatty Acid-Binding Proteins - genetics Fatty acids Female Food intake Fundamental and applied biological sciences. Psychology Gene Expression Glucose Glucose tolerance High fat diet I-kappa B Kinase - genetics I-kappa B Kinase - metabolism IKK protein Inflammation Inflammation Mediators - metabolism Insulin Insulin Resistance Kinases Male Medical sciences Metabolic diseases Metabolism Mice Mice, Inbred C57BL Mice, Transgenic Obesity Obesity - enzymology Obesity - etiology Obesity - pathology Obesity - prevention & control Promoter Regions, Genetic Protein turnover Resistance factors Transgenic mice Triglycerides Vertebrates: endocrinology
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