Dual-Energy CT for Characterization of the Incidental Adrenal Mass: Preliminary Observations
The purpose of our study was to evaluate the accuracy of virtual unenhanced images reconstructed from contrast-enhanced dual-energy CT for the differentiation of incidental adrenal masses in comparison with standard unenhanced CT. One hundred-forty patients (mean age, 74±9 years) underwent unenhance...
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| Veröffentlicht in: | American journal of roentgenology (1976) 2012, Vol.198 (1), p.138-144 |
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| container_title | American journal of roentgenology (1976) |
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| creator | GNANNT, Ralph FISCHER, Michael GOETTI, Robert KARLO, Christoph LESCHKA, Sebastian ALKADHI, Hatem |
| description | The purpose of our study was to evaluate the accuracy of virtual unenhanced images reconstructed from contrast-enhanced dual-energy CT for the differentiation of incidental adrenal masses in comparison with standard unenhanced CT.
One hundred-forty patients (mean age, 74±9 years) underwent unenhanced and contrast-enhanced CT of the abdomen, the latter acquired with dual-energy for reconstruction of virtual unenhanced images. Two blinded and independent readers (R1 and R2) measured attenuation of each incidental adrenal mass on standard unenhanced and virtual unenhanced images using an optimized dual-energy three-material decomposition algorithm.
Fifty-one incidental adrenal masses were found in 42 of 135 patients (31%); 39 incidental adrenal masses were ≥1 cm. On the basis of unenhanced CT, 29 of 51 incidental adrenal masses and 22 of 39 incidental adrenal masses≥1 cm were classified as benign (HU |
| doi_str_mv | 10.2214/AJR.11.6957 |
| format | Article |
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One hundred-forty patients (mean age, 74±9 years) underwent unenhanced and contrast-enhanced CT of the abdomen, the latter acquired with dual-energy for reconstruction of virtual unenhanced images. Two blinded and independent readers (R1 and R2) measured attenuation of each incidental adrenal mass on standard unenhanced and virtual unenhanced images using an optimized dual-energy three-material decomposition algorithm.
Fifty-one incidental adrenal masses were found in 42 of 135 patients (31%); 39 incidental adrenal masses were ≥1 cm. On the basis of unenhanced CT, 29 of 51 incidental adrenal masses and 22 of 39 incidental adrenal masses≥1 cm were classified as benign (HU<10). Virtual unenhanced image quality was rated as good or with mild impairment (2.45±0.83 for R1, 2.45±0.99 for R2). Image noise was 12.7±3.6 HU in unenhanced images and 8.8±2.0 HU in virtual unenhanced images (p<0.001). There was no significant difference in incidental adrenal mass attenuation between unenhanced and virtual unenhanced images for all incidental adrenal masses (5.9±21.0 HU vs 7.0±20.6 HU, p=0.48) and for those≥1 cm (6.6±18.5 HU vs 7.9±18.3 HU, p=0.87). Sensitivity, specificity, and accuracy of virtual unenhanced images for the characterization of incidental adrenal masses as probably benign were 76%, 82%, and 78% for R1 and 79%, 95%, and 86% for R2, respectively. For incidental adrenal masses≥1 cm, sensitivity, specificity, and accuracy increased to 95%, 100%, and 97% for R1 and 91%, 100%, and 95% for R2.
Reconstruction of virtual unenhanced images from contrast-enhanced dual-energy CT of the abdomen allows the characterization of the incidental adrenal masses with a good accuracy compared with standard unenhanced CT, with the most favorable results in incidental adrenal masses measuring≥1 cm.</description><identifier>ISSN: 0361-803X</identifier><identifier>EISSN: 1546-3141</identifier><identifier>DOI: 10.2214/AJR.11.6957</identifier><identifier>PMID: 22194489</identifier><identifier>CODEN: AAJRDX</identifier><language>eng</language><publisher>Reston, VA: American Roentgen Ray Society</publisher><subject>Adrenal Gland Diseases - diagnostic imaging ; Adrenal Gland Neoplasms - diagnostic imaging ; Adult ; Aged ; Aged, 80 and over ; Algorithms ; Biological and medical sciences ; Chi-Square Distribution ; Contrast Media ; Female ; Humans ; Incidental Findings ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, X-Ray Computed - methods</subject><ispartof>American journal of roentgenology (1976), 2012, Vol.198 (1), p.138-144</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-c64b5a40b6881c7aadad551e85d661cf7642095bf8c2adc7238c7edab310a83f3</citedby><cites>FETCH-LOGICAL-c351t-c64b5a40b6881c7aadad551e85d661cf7642095bf8c2adc7238c7edab310a83f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,4106,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25505364$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22194489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GNANNT, Ralph</creatorcontrib><creatorcontrib>FISCHER, Michael</creatorcontrib><creatorcontrib>GOETTI, Robert</creatorcontrib><creatorcontrib>KARLO, Christoph</creatorcontrib><creatorcontrib>LESCHKA, Sebastian</creatorcontrib><creatorcontrib>ALKADHI, Hatem</creatorcontrib><title>Dual-Energy CT for Characterization of the Incidental Adrenal Mass: Preliminary Observations</title><title>American journal of roentgenology (1976)</title><addtitle>AJR Am J Roentgenol</addtitle><description>The purpose of our study was to evaluate the accuracy of virtual unenhanced images reconstructed from contrast-enhanced dual-energy CT for the differentiation of incidental adrenal masses in comparison with standard unenhanced CT.
One hundred-forty patients (mean age, 74±9 years) underwent unenhanced and contrast-enhanced CT of the abdomen, the latter acquired with dual-energy for reconstruction of virtual unenhanced images. Two blinded and independent readers (R1 and R2) measured attenuation of each incidental adrenal mass on standard unenhanced and virtual unenhanced images using an optimized dual-energy three-material decomposition algorithm.
Fifty-one incidental adrenal masses were found in 42 of 135 patients (31%); 39 incidental adrenal masses were ≥1 cm. On the basis of unenhanced CT, 29 of 51 incidental adrenal masses and 22 of 39 incidental adrenal masses≥1 cm were classified as benign (HU<10). Virtual unenhanced image quality was rated as good or with mild impairment (2.45±0.83 for R1, 2.45±0.99 for R2). Image noise was 12.7±3.6 HU in unenhanced images and 8.8±2.0 HU in virtual unenhanced images (p<0.001). There was no significant difference in incidental adrenal mass attenuation between unenhanced and virtual unenhanced images for all incidental adrenal masses (5.9±21.0 HU vs 7.0±20.6 HU, p=0.48) and for those≥1 cm (6.6±18.5 HU vs 7.9±18.3 HU, p=0.87). Sensitivity, specificity, and accuracy of virtual unenhanced images for the characterization of incidental adrenal masses as probably benign were 76%, 82%, and 78% for R1 and 79%, 95%, and 86% for R2, respectively. For incidental adrenal masses≥1 cm, sensitivity, specificity, and accuracy increased to 95%, 100%, and 97% for R1 and 91%, 100%, and 95% for R2.
Reconstruction of virtual unenhanced images from contrast-enhanced dual-energy CT of the abdomen allows the characterization of the incidental adrenal masses with a good accuracy compared with standard unenhanced CT, with the most favorable results in incidental adrenal masses measuring≥1 cm.</description><subject>Adrenal Gland Diseases - diagnostic imaging</subject><subject>Adrenal Gland Neoplasms - diagnostic imaging</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Chi-Square Distribution</subject><subject>Contrast Media</subject><subject>Female</subject><subject>Humans</subject><subject>Incidental Findings</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>0361-803X</issn><issn>1546-3141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1Lw0AQgOFFFK0fJ--yF1GQ1J3sRzbeSq1aURSp4EEIk81GI2lSd1Oh_npXrXrzNJdnBuYlZBdYP45BHA8u7_oAfZXKZIX0QAoVcRCwSnqMK4g04w8bZNP7F8ZYotNknWyEvVQInfbI4-kc62jUWPe0oMMJLVtHh8_o0HTWVe_YVW1D25J2z5aOG1MVtumwpoPC2SbMa_T-hN46W1fTqkG3oDe5t-7ta89vk7USa293lnOL3J-NJsOL6OrmfDwcXEWGS-gio0QuUbBcaQ0mQSywkBKsloVSYMpEiZilMi-1ibEwScy1SWyBOQeGmpd8ixx835259nVufZdNK29sXWNj27nPUoiVABAiyMN_JTCmtUh0LAM9-qbGtd47W2YzV03DiwFln-GzED4DyD7DB723PDzPp7b4tT-lA9hfAvQG69JhqOn_nJRMciX4B2qmipQ</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>GNANNT, Ralph</creator><creator>FISCHER, Michael</creator><creator>GOETTI, Robert</creator><creator>KARLO, Christoph</creator><creator>LESCHKA, Sebastian</creator><creator>ALKADHI, Hatem</creator><general>American Roentgen Ray Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Dual-Energy CT for Characterization of the Incidental Adrenal Mass: Preliminary Observations</title><author>GNANNT, Ralph ; FISCHER, Michael ; GOETTI, Robert ; KARLO, Christoph ; LESCHKA, Sebastian ; ALKADHI, Hatem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-c64b5a40b6881c7aadad551e85d661cf7642095bf8c2adc7238c7edab310a83f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adrenal Gland Diseases - diagnostic imaging</topic><topic>Adrenal Gland Neoplasms - diagnostic imaging</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Chi-Square Distribution</topic><topic>Contrast Media</topic><topic>Female</topic><topic>Humans</topic><topic>Incidental Findings</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GNANNT, Ralph</creatorcontrib><creatorcontrib>FISCHER, Michael</creatorcontrib><creatorcontrib>GOETTI, Robert</creatorcontrib><creatorcontrib>KARLO, Christoph</creatorcontrib><creatorcontrib>LESCHKA, Sebastian</creatorcontrib><creatorcontrib>ALKADHI, Hatem</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of roentgenology (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GNANNT, Ralph</au><au>FISCHER, Michael</au><au>GOETTI, Robert</au><au>KARLO, Christoph</au><au>LESCHKA, Sebastian</au><au>ALKADHI, Hatem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dual-Energy CT for Characterization of the Incidental Adrenal Mass: Preliminary Observations</atitle><jtitle>American journal of roentgenology (1976)</jtitle><addtitle>AJR Am J Roentgenol</addtitle><date>2012</date><risdate>2012</risdate><volume>198</volume><issue>1</issue><spage>138</spage><epage>144</epage><pages>138-144</pages><issn>0361-803X</issn><eissn>1546-3141</eissn><coden>AAJRDX</coden><abstract>The purpose of our study was to evaluate the accuracy of virtual unenhanced images reconstructed from contrast-enhanced dual-energy CT for the differentiation of incidental adrenal masses in comparison with standard unenhanced CT.
One hundred-forty patients (mean age, 74±9 years) underwent unenhanced and contrast-enhanced CT of the abdomen, the latter acquired with dual-energy for reconstruction of virtual unenhanced images. Two blinded and independent readers (R1 and R2) measured attenuation of each incidental adrenal mass on standard unenhanced and virtual unenhanced images using an optimized dual-energy three-material decomposition algorithm.
Fifty-one incidental adrenal masses were found in 42 of 135 patients (31%); 39 incidental adrenal masses were ≥1 cm. On the basis of unenhanced CT, 29 of 51 incidental adrenal masses and 22 of 39 incidental adrenal masses≥1 cm were classified as benign (HU<10). Virtual unenhanced image quality was rated as good or with mild impairment (2.45±0.83 for R1, 2.45±0.99 for R2). Image noise was 12.7±3.6 HU in unenhanced images and 8.8±2.0 HU in virtual unenhanced images (p<0.001). There was no significant difference in incidental adrenal mass attenuation between unenhanced and virtual unenhanced images for all incidental adrenal masses (5.9±21.0 HU vs 7.0±20.6 HU, p=0.48) and for those≥1 cm (6.6±18.5 HU vs 7.9±18.3 HU, p=0.87). Sensitivity, specificity, and accuracy of virtual unenhanced images for the characterization of incidental adrenal masses as probably benign were 76%, 82%, and 78% for R1 and 79%, 95%, and 86% for R2, respectively. For incidental adrenal masses≥1 cm, sensitivity, specificity, and accuracy increased to 95%, 100%, and 97% for R1 and 91%, 100%, and 95% for R2.
Reconstruction of virtual unenhanced images from contrast-enhanced dual-energy CT of the abdomen allows the characterization of the incidental adrenal masses with a good accuracy compared with standard unenhanced CT, with the most favorable results in incidental adrenal masses measuring≥1 cm.</abstract><cop>Reston, VA</cop><pub>American Roentgen Ray Society</pub><pmid>22194489</pmid><doi>10.2214/AJR.11.6957</doi><tpages>7</tpages></addata></record> |
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| ispartof | American journal of roentgenology (1976), 2012, Vol.198 (1), p.138-144 |
| issn | 0361-803X 1546-3141 |
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| source | American Roentgen Ray Society; MEDLINE; Alma/SFX Local Collection |
| subjects | Adrenal Gland Diseases - diagnostic imaging Adrenal Gland Neoplasms - diagnostic imaging Adult Aged Aged, 80 and over Algorithms Biological and medical sciences Chi-Square Distribution Contrast Media Female Humans Incidental Findings Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed - methods |
| title | Dual-Energy CT for Characterization of the Incidental Adrenal Mass: Preliminary Observations |
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