Microneurographic identification of spontaneous activity in C-nociceptors in neuropathic pain states in humans and rats

Microneurography can detect spontaneous activity in C-nociceptors in neuropathic pain states in humans and in rats. C-nociceptors do not normally fire action potentials unless challenged by adequate noxious stimuli. However, in pathological states nociceptors may become hyperexcitable and may genera...

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Veröffentlicht in:	Pain (Amsterdam) 2012, Vol.153 (1), p.42-55
Hauptverfasser:	Serra, Jordi, Bostock, Hugh, Solà, Romà, Aleu, Jordi, García, Elizabeth, Cokic, Barbara, Navarro, Xavier, Quiles, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Adult Aged Animals Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Humans Hyperalgesia - physiopathology Illness and personality Illness, stress and coping Male Medical sciences Microneurography Middle Aged Nerve Fibers, Unmyelinated - physiology Nervous system (semeiology, syndromes) Neuralgia - physiopathology Neurology Neuropathic pain Nociceptor Nociceptors - physiology Pain Threshold - physiology Peripheral Nervous System Diseases - physiopathology Psychology and medicine Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley
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