T cell-mediated increased osteoclast formation from peripheral blood as a mechanism for crohn's disease-associated bone loss

The pathophysiology of osteoporosis in patients with Crohn's disease (CD) is still not completely elucidated. In this study, we evaluated osteoclastogenesis from peripheral blood cells of CD patients and studied the role of lymphocytes and inflammatory cytokines in this process. Peripheral bloo...

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Veröffentlicht in:	Journal of cellular biochemistry 2012-01, Vol.113 (1), p.260-268
Hauptverfasser:	Oostlander, Angela E., Everts, Vincent, Schoenmaker, Ton, Bravenboer, Nathalie, van Vliet, Sandra J., van Bodegraven, Ad A., Lips, Paul, de Vries, Teun J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bone Resorption - etiology Bone Resorption - pathology Cell Proliferation Cells, Cultured Crohn Disease - complications Crohn Disease - immunology Crohn Disease - metabolism Cytokines - immunology Female Humans IL-17 Inflammatory bowel disease Interleukin-17 - immunology Macrophage Colony-Stimulating Factor - deficiency Male Osteoclastogenesis Osteoclasts - cytology Osteoclasts - immunology Osteoclasts - metabolism Osteoporosis - physiopathology Peripheral blood RANK Ligand - deficiency T cell T-Lymphocytes - metabolism
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