Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signalling

8-Nitro-cGMP (8-nitroguanosine 3',5'-cyclic monophosphate) is a nitrated derivative of cGMP, which can function as a unique electrophilic second messenger involved in regulation of an antioxidant adaptive response in cells. In the present study, we investigated chemical and biochemical reg...

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Veröffentlicht in:	Biochemical journal 2012-01, Vol.441 (2), p.719-730
Hauptverfasser:	Ahmed, Khandaker Ahtesham, Sawa, Tomohiro, Ihara, Hideshi, Kasamatsu, Shingo, Yoshitake, Jun, Rahaman, Md Mizanur, Okamoto, Tatsuya, Fujii, Shigemoto, Akaike, Takaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt - pharmacology Animals Cell Line, Tumor Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology Hydrogen Peroxide - metabolism Lipopolysaccharides - pharmacology Mitochondria - drug effects Mitochondria - metabolism NADPH Oxidases - metabolism Nitrogen Oxides - metabolism Peroxynitrous Acid - metabolism Rats Reactive Nitrogen Species - metabolism Reactive Oxygen Species - metabolism Rotenone - pharmacology Signal Transduction - physiology Superoxides - metabolism
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