Is nevirapine atropisomeric? Experimental and computational evidence for rapid conformational inversion

The non-nucleoside reverse transcriptase inhibitor nevirapine displays in its room temperature (1)H-NMR spectrum signals characteristic of a chiral compound. Following suggestions in the recent literature that nevirapine may display atropisomerism-and therefore be a chiral compound, due to slow inte...

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Veröffentlicht in:	Organic & biomolecular chemistry 2012-01, Vol.10 (4), p.716-719
Hauptverfasser:	Burke, Edmund W D, Morris, Gareth A, Vincent, Mark A, Hillier, Ian H, Clayden, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - chemistry Isomerism Magnetic Resonance Spectroscopy Models, Molecular Nevirapine - chemistry
Online-Zugang:	Volltext
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