Photocrosslinked poly(ester anhydride)s for peptide delivery: Effect of oligomer hydrophobicity on PYY3-36 delivery
Functionalization of poly(ester anhydride) oligomers with 12-carbon alkenyl chain delays PYY3-36 release in vivo in comparison with SAH-functionalized oligomers without alkenyl chain. The treatment for many diseases can be improved by developing more efficient peptide delivery technologies, for exam...
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| Veröffentlicht in: | European journal of pharmaceutics and biopharmaceutics 2012, Vol.80 (1), p.33-38 |
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| container_title | European journal of pharmaceutics and biopharmaceutics |
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| creator | Mönkäre, Juha Hakala, Risto A. Kovalainen, Miia Korhonen, Harri Herzig, Karl-Heinz Seppälä, Jukka V. Järvinen, Kristiina |
| description | Functionalization of poly(ester anhydride) oligomers with 12-carbon alkenyl chain delays PYY3-36 release
in vivo in comparison with SAH-functionalized oligomers without alkenyl chain.
The treatment for many diseases can be improved by developing more efficient peptide delivery technologies, for example, biodegradable polymers. In this work, photocrosslinked poly(ester anhydride)s based on functionalized poly(ε-caprolactone) oligomers were investigated for their abilities to achieve controlled peptide delivery. The effect of oligomer hydrophobicity on erosion and peptide release from poly(ester anhydride)s was evaluated by developing a sustained subcutaneous delivery system for an antiobesity drug candidate, peptide YY3-36 (PYY3-36). Oligomer hydrophobicity was modified with alkenylsuccinic anhydrides containing a 12-carbon alkenyl chain. PYY3-36 was mixed as a solid powder with methacrylated poly(ester anhydride) precursors, and this mixture was photocrosslinked at room temperature to form an implant for subcutaneous administration in rats. The oligomer hydrophobicity controlled the polymer erosion and PYY3-36 release as the increased hydrophobicity via the alkenyl chain prolonged polymer erosion
in vitro and sustained
in vivo release of PYY3-36. In addition, photocrosslinked poly(ester anhydride)s increased the bioavailability of PYY3-36 by up to 20-fold in comparison with subcutaneous administration of solution, evidence of remarkably improved delivery. In conclusion, this work demonstrates the suitability of photocrosslinked poly(ester anhydride)s for use in peptide delivery. |
| doi_str_mv | 10.1016/j.ejpb.2011.09.011 |
| format | Article |
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in vivo in comparison with SAH-functionalized oligomers without alkenyl chain.
The treatment for many diseases can be improved by developing more efficient peptide delivery technologies, for example, biodegradable polymers. In this work, photocrosslinked poly(ester anhydride)s based on functionalized poly(ε-caprolactone) oligomers were investigated for their abilities to achieve controlled peptide delivery. The effect of oligomer hydrophobicity on erosion and peptide release from poly(ester anhydride)s was evaluated by developing a sustained subcutaneous delivery system for an antiobesity drug candidate, peptide YY3-36 (PYY3-36). Oligomer hydrophobicity was modified with alkenylsuccinic anhydrides containing a 12-carbon alkenyl chain. PYY3-36 was mixed as a solid powder with methacrylated poly(ester anhydride) precursors, and this mixture was photocrosslinked at room temperature to form an implant for subcutaneous administration in rats. The oligomer hydrophobicity controlled the polymer erosion and PYY3-36 release as the increased hydrophobicity via the alkenyl chain prolonged polymer erosion
in vitro and sustained
in vivo release of PYY3-36. In addition, photocrosslinked poly(ester anhydride)s increased the bioavailability of PYY3-36 by up to 20-fold in comparison with subcutaneous administration of solution, evidence of remarkably improved delivery. In conclusion, this work demonstrates the suitability of photocrosslinked poly(ester anhydride)s for use in peptide delivery.</description><identifier>ISSN: 0939-6411</identifier><identifier>EISSN: 1873-3441</identifier><identifier>DOI: 10.1016/j.ejpb.2011.09.011</identifier><identifier>PMID: 21964317</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Bioavailability ; Biological and medical sciences ; Biological Availability ; Controlled release ; Delayed-Action Preparations ; Drug Delivery Systems - methods ; General pharmacology ; Humans ; Hydrophobic and Hydrophilic Interactions ; Hypodermoclysis - methods ; Male ; Medical sciences ; Peptide Fragments ; Peptide YY - administration & dosage ; Peptide YY - chemistry ; Peptide YY - pharmacokinetics ; Peptide YY3-36 ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacokinetics ; Pharmacology. Drug treatments ; Photocrosslinking ; Poly(ester anhydride) ; Polymers - administration & dosage ; Polymers - chemistry ; Powders - administration & dosage ; Powders - chemistry ; Powders - pharmacokinetics ; Rats ; Rats, Wistar ; Succinic Anhydrides - chemistry</subject><ispartof>European journal of pharmaceutics and biopharmaceutics, 2012, Vol.80 (1), p.33-38</ispartof><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-a90e6ae900e1853d3270ccc6c961dbc7abe633dc0309eb1efc8497d72c2ab2213</citedby><cites>FETCH-LOGICAL-c385t-a90e6ae900e1853d3270ccc6c961dbc7abe633dc0309eb1efc8497d72c2ab2213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejpb.2011.09.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25400019$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21964317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mönkäre, Juha</creatorcontrib><creatorcontrib>Hakala, Risto A.</creatorcontrib><creatorcontrib>Kovalainen, Miia</creatorcontrib><creatorcontrib>Korhonen, Harri</creatorcontrib><creatorcontrib>Herzig, Karl-Heinz</creatorcontrib><creatorcontrib>Seppälä, Jukka V.</creatorcontrib><creatorcontrib>Järvinen, Kristiina</creatorcontrib><title>Photocrosslinked poly(ester anhydride)s for peptide delivery: Effect of oligomer hydrophobicity on PYY3-36 delivery</title><title>European journal of pharmaceutics and biopharmaceutics</title><addtitle>Eur J Pharm Biopharm</addtitle><description>Functionalization of poly(ester anhydride) oligomers with 12-carbon alkenyl chain delays PYY3-36 release
in vivo in comparison with SAH-functionalized oligomers without alkenyl chain.
The treatment for many diseases can be improved by developing more efficient peptide delivery technologies, for example, biodegradable polymers. In this work, photocrosslinked poly(ester anhydride)s based on functionalized poly(ε-caprolactone) oligomers were investigated for their abilities to achieve controlled peptide delivery. The effect of oligomer hydrophobicity on erosion and peptide release from poly(ester anhydride)s was evaluated by developing a sustained subcutaneous delivery system for an antiobesity drug candidate, peptide YY3-36 (PYY3-36). Oligomer hydrophobicity was modified with alkenylsuccinic anhydrides containing a 12-carbon alkenyl chain. PYY3-36 was mixed as a solid powder with methacrylated poly(ester anhydride) precursors, and this mixture was photocrosslinked at room temperature to form an implant for subcutaneous administration in rats. The oligomer hydrophobicity controlled the polymer erosion and PYY3-36 release as the increased hydrophobicity via the alkenyl chain prolonged polymer erosion
in vitro and sustained
in vivo release of PYY3-36. In addition, photocrosslinked poly(ester anhydride)s increased the bioavailability of PYY3-36 by up to 20-fold in comparison with subcutaneous administration of solution, evidence of remarkably improved delivery. In conclusion, this work demonstrates the suitability of photocrosslinked poly(ester anhydride)s for use in peptide delivery.</description><subject>Animals</subject><subject>Bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Controlled release</subject><subject>Delayed-Action Preparations</subject><subject>Drug Delivery Systems - methods</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Hypodermoclysis - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Peptide Fragments</subject><subject>Peptide YY - administration & dosage</subject><subject>Peptide YY - chemistry</subject><subject>Peptide YY - pharmacokinetics</subject><subject>Peptide YY3-36</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Photocrosslinking</subject><subject>Poly(ester anhydride)</subject><subject>Polymers - administration & dosage</subject><subject>Polymers - chemistry</subject><subject>Powders - administration & dosage</subject><subject>Powders - chemistry</subject><subject>Powders - pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Succinic Anhydrides - chemistry</subject><issn>0939-6411</issn><issn>1873-3441</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EarelL9AD8gXRHhI8dtaJEZeqagGpEj3AoSfLsSddL9k42NlKeft62aXcOP2y9P2j8TeEnAMrgYH8uC5xPbYlZwAlU2WOV2QBTS0KUVXwmiyYEqqQFcAxOUlpzRir6mVzRI45KFkJqBck3a_CFGwMKfV--IWOjqGfLzBNGKkZVrOL3uFlol2IdMRxyi_qsPdPGOdP9Kbr0E40dDT0_jFscmlXCeMqtN76aaZhoPcPD3kl-VJ7S950pk94dshT8vP25sf11-Lu-5dv11d3hRXNciqMYigNKsYQmqVwgtfMWiutkuBaW5sWpRDOMsEUtoCdbSpVu5pbblrOQZySD_u5Ywy_t_lLeuOTxb43A4Zt0gp4xWuQLJN8T_4REbHTY_QbE2cNTO9c67XeudY715opnSOX3h3Gb9sNupfKX7kZeH8ATLKm76IZrE__uGWVLwIqc5_3HGYZTx6jTtbjYNH5mO1qF_z_9ngGaCSeew</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Mönkäre, Juha</creator><creator>Hakala, Risto A.</creator><creator>Kovalainen, Miia</creator><creator>Korhonen, Harri</creator><creator>Herzig, Karl-Heinz</creator><creator>Seppälä, Jukka V.</creator><creator>Järvinen, Kristiina</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Photocrosslinked poly(ester anhydride)s for peptide delivery: Effect of oligomer hydrophobicity on PYY3-36 delivery</title><author>Mönkäre, Juha ; Hakala, Risto A. ; Kovalainen, Miia ; Korhonen, Harri ; Herzig, Karl-Heinz ; Seppälä, Jukka V. ; Järvinen, Kristiina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-a90e6ae900e1853d3270ccc6c961dbc7abe633dc0309eb1efc8497d72c2ab2213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Controlled release</topic><topic>Delayed-Action Preparations</topic><topic>Drug Delivery Systems - methods</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Hypodermoclysis - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Peptide Fragments</topic><topic>Peptide YY - administration & dosage</topic><topic>Peptide YY - chemistry</topic><topic>Peptide YY - pharmacokinetics</topic><topic>Peptide YY3-36</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Photocrosslinking</topic><topic>Poly(ester anhydride)</topic><topic>Polymers - administration & dosage</topic><topic>Polymers - chemistry</topic><topic>Powders - administration & dosage</topic><topic>Powders - chemistry</topic><topic>Powders - pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Succinic Anhydrides - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mönkäre, Juha</creatorcontrib><creatorcontrib>Hakala, Risto A.</creatorcontrib><creatorcontrib>Kovalainen, Miia</creatorcontrib><creatorcontrib>Korhonen, Harri</creatorcontrib><creatorcontrib>Herzig, Karl-Heinz</creatorcontrib><creatorcontrib>Seppälä, Jukka V.</creatorcontrib><creatorcontrib>Järvinen, Kristiina</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mönkäre, Juha</au><au>Hakala, Risto A.</au><au>Kovalainen, Miia</au><au>Korhonen, Harri</au><au>Herzig, Karl-Heinz</au><au>Seppälä, Jukka V.</au><au>Järvinen, Kristiina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photocrosslinked poly(ester anhydride)s for peptide delivery: Effect of oligomer hydrophobicity on PYY3-36 delivery</atitle><jtitle>European journal of pharmaceutics and biopharmaceutics</jtitle><addtitle>Eur J Pharm Biopharm</addtitle><date>2012</date><risdate>2012</risdate><volume>80</volume><issue>1</issue><spage>33</spage><epage>38</epage><pages>33-38</pages><issn>0939-6411</issn><eissn>1873-3441</eissn><abstract>Functionalization of poly(ester anhydride) oligomers with 12-carbon alkenyl chain delays PYY3-36 release
in vivo in comparison with SAH-functionalized oligomers without alkenyl chain.
The treatment for many diseases can be improved by developing more efficient peptide delivery technologies, for example, biodegradable polymers. In this work, photocrosslinked poly(ester anhydride)s based on functionalized poly(ε-caprolactone) oligomers were investigated for their abilities to achieve controlled peptide delivery. The effect of oligomer hydrophobicity on erosion and peptide release from poly(ester anhydride)s was evaluated by developing a sustained subcutaneous delivery system for an antiobesity drug candidate, peptide YY3-36 (PYY3-36). Oligomer hydrophobicity was modified with alkenylsuccinic anhydrides containing a 12-carbon alkenyl chain. PYY3-36 was mixed as a solid powder with methacrylated poly(ester anhydride) precursors, and this mixture was photocrosslinked at room temperature to form an implant for subcutaneous administration in rats. The oligomer hydrophobicity controlled the polymer erosion and PYY3-36 release as the increased hydrophobicity via the alkenyl chain prolonged polymer erosion
in vitro and sustained
in vivo release of PYY3-36. In addition, photocrosslinked poly(ester anhydride)s increased the bioavailability of PYY3-36 by up to 20-fold in comparison with subcutaneous administration of solution, evidence of remarkably improved delivery. In conclusion, this work demonstrates the suitability of photocrosslinked poly(ester anhydride)s for use in peptide delivery.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21964317</pmid><doi>10.1016/j.ejpb.2011.09.011</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0939-6411 |
| ispartof | European journal of pharmaceutics and biopharmaceutics, 2012, Vol.80 (1), p.33-38 |
| issn | 0939-6411 1873-3441 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Bioavailability Biological and medical sciences Biological Availability Controlled release Delayed-Action Preparations Drug Delivery Systems - methods General pharmacology Humans Hydrophobic and Hydrophilic Interactions Hypodermoclysis - methods Male Medical sciences Peptide Fragments Peptide YY - administration & dosage Peptide YY - chemistry Peptide YY - pharmacokinetics Peptide YY3-36 Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics Pharmacology. Drug treatments Photocrosslinking Poly(ester anhydride) Polymers - administration & dosage Polymers - chemistry Powders - administration & dosage Powders - chemistry Powders - pharmacokinetics Rats Rats, Wistar Succinic Anhydrides - chemistry |
| title | Photocrosslinked poly(ester anhydride)s for peptide delivery: Effect of oligomer hydrophobicity on PYY3-36 delivery |
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