Development of novel diclofenac potassium controlled release tablets by wet granulation technique and the effect of co-excipients on in vitro drug release rates
The aim of the present study was the formulation and evaluation of controlled release polymeric tablets of Diclofenac Potassium by wet granulation method for the release rate, release pattern and the mechanism involved in drug release. Formulations having three grades of polymer Ethocel (7P; 7FP, 10...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2012-01, Vol.25 (1), p.161-168 |
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| container_end_page | 168 |
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| container_title | Pakistan journal of pharmaceutical sciences |
| container_volume | 25 |
| creator | Shah, Shefaatullah Khan, Gul Majid Jan, Syed Umer Shah, Kifayatullah Hussain, Abid Khan, Haroon Khan, Kamran Ahmad |
| description | The aim of the present study was the formulation and evaluation of controlled release polymeric tablets of Diclofenac Potassium by wet granulation method for the release rate, release pattern and the mechanism involved in drug release. Formulations having three grades of polymer Ethocel (7P; 7FP, 10P, 10FP, 100P, 100FP) in several drugs to polymer ratios (10:3 and 10:1) were compressed into tablets using wet granulation method. Co-excipients were added to some selected formulations to investigate their enhancement effect on in vitro drug release patterns. In vitro drug release studies were performed using USP Method-1 (Rotating Basket method) and Phosphate buffer (pH 7.4) was used as a dissolution medium. The similarities and dissimilarities of release profiles of test formulations with reference standard were checked using f2 similarity factor and f1 dissimilarity factor. Mathematical/Kinetic models were employed to determine the release mechanism and drug release kinetics. |
| format | Article |
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Formulations having three grades of polymer Ethocel (7P; 7FP, 10P, 10FP, 100P, 100FP) in several drugs to polymer ratios (10:3 and 10:1) were compressed into tablets using wet granulation method. Co-excipients were added to some selected formulations to investigate their enhancement effect on in vitro drug release patterns. In vitro drug release studies were performed using USP Method-1 (Rotating Basket method) and Phosphate buffer (pH 7.4) was used as a dissolution medium. The similarities and dissimilarities of release profiles of test formulations with reference standard were checked using f2 similarity factor and f1 dissimilarity factor. Mathematical/Kinetic models were employed to determine the release mechanism and drug release kinetics.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 22186325</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Cellulose - analogs & derivatives ; Cellulose - chemistry ; Chemistry, Pharmaceutical - methods ; Controlled release ; Controlled release preparations ; Delayed-Action Preparations - chemistry ; Diclofenac ; Diclofenac - administration & dosage ; Diclofenac - chemistry ; Drug Compounding - methods ; Drug Compounding - statistics & numerical data ; Drugs ; Excipients ; Excipients - chemistry ; Hydrogen-Ion Concentration ; In Vitro Techniques ; Kinetics ; Production processes ; Solubility ; Tablets - chemistry</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2012-01, Vol.25 (1), p.161-168</ispartof><rights>COPYRIGHT 2012 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22186325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shah, Shefaatullah</creatorcontrib><creatorcontrib>Khan, Gul Majid</creatorcontrib><creatorcontrib>Jan, Syed Umer</creatorcontrib><creatorcontrib>Shah, Kifayatullah</creatorcontrib><creatorcontrib>Hussain, Abid</creatorcontrib><creatorcontrib>Khan, Haroon</creatorcontrib><creatorcontrib>Khan, Kamran Ahmad</creatorcontrib><title>Development of novel diclofenac potassium controlled release tablets by wet granulation technique and the effect of co-excipients on in vitro drug release rates</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>The aim of the present study was the formulation and evaluation of controlled release polymeric tablets of Diclofenac Potassium by wet granulation method for the release rate, release pattern and the mechanism involved in drug release. Formulations having three grades of polymer Ethocel (7P; 7FP, 10P, 10FP, 100P, 100FP) in several drugs to polymer ratios (10:3 and 10:1) were compressed into tablets using wet granulation method. Co-excipients were added to some selected formulations to investigate their enhancement effect on in vitro drug release patterns. In vitro drug release studies were performed using USP Method-1 (Rotating Basket method) and Phosphate buffer (pH 7.4) was used as a dissolution medium. The similarities and dissimilarities of release profiles of test formulations with reference standard were checked using f2 similarity factor and f1 dissimilarity factor. Mathematical/Kinetic models were employed to determine the release mechanism and drug release kinetics.</description><subject>Cellulose - analogs & derivatives</subject><subject>Cellulose - chemistry</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Controlled release</subject><subject>Controlled release preparations</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Diclofenac</subject><subject>Diclofenac - administration & dosage</subject><subject>Diclofenac - chemistry</subject><subject>Drug Compounding - methods</subject><subject>Drug Compounding - statistics & numerical data</subject><subject>Drugs</subject><subject>Excipients</subject><subject>Excipients - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Production processes</subject><subject>Solubility</subject><subject>Tablets - chemistry</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU1LBDEMhueg6PrxFyTgwdNIp_Ox06Osn7DgRcHb0GnTtdJpx7az6r_xp1p1FQTJISQ8ed-QbGWzghRF3pDiYTfbC-GJkKZijO1ku5QWbVPSepa9n-MajRsHtBGcAutSCVIL4xRaLmB0kYegpwGEs9E7Y1CCR4M8IETeG4wB-jd4wQgrz-1keNTOQkTxaPXzhMCthPiIgEqh-DIRLsdXoUedTAMkWFtY6yQO0k-rX3XPI4aDbFtxE_Bwk_ez-8uLu8V1vry9ulmcLfMVnc9j3leq5w0jVV03ChmjUtQ1UVXBOFaVkvNGlrInSElLW97WommlKHrS16lF5qzcz06-dUfv0tYhdoMOAo3hFt0UOlbQilYtoYk8_iZX3GCnrXLRc_FJd2eUlWWdyCZRp_9QKSQOOp0SlU79PwNHmwWmfkDZjV4P3L91P78qPwCJl5Gl</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Shah, Shefaatullah</creator><creator>Khan, Gul Majid</creator><creator>Jan, Syed Umer</creator><creator>Shah, Kifayatullah</creator><creator>Hussain, Abid</creator><creator>Khan, Haroon</creator><creator>Khan, Kamran Ahmad</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>Development of novel diclofenac potassium controlled release tablets by wet granulation technique and the effect of co-excipients on in vitro drug release rates</title><author>Shah, Shefaatullah ; Khan, Gul Majid ; Jan, Syed Umer ; Shah, Kifayatullah ; Hussain, Abid ; Khan, Haroon ; Khan, Kamran Ahmad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g277t-b4fba6904556fe992dc550f419ae44fd76d3db0e20828a85c68dc1b0b5e200793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Cellulose - analogs & derivatives</topic><topic>Cellulose - chemistry</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Controlled release</topic><topic>Controlled release preparations</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Diclofenac</topic><topic>Diclofenac - administration & dosage</topic><topic>Diclofenac - chemistry</topic><topic>Drug Compounding - methods</topic><topic>Drug Compounding - statistics & numerical data</topic><topic>Drugs</topic><topic>Excipients</topic><topic>Excipients - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Production processes</topic><topic>Solubility</topic><topic>Tablets - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shah, Shefaatullah</creatorcontrib><creatorcontrib>Khan, Gul Majid</creatorcontrib><creatorcontrib>Jan, Syed Umer</creatorcontrib><creatorcontrib>Shah, Kifayatullah</creatorcontrib><creatorcontrib>Hussain, Abid</creatorcontrib><creatorcontrib>Khan, Haroon</creatorcontrib><creatorcontrib>Khan, Kamran Ahmad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shah, Shefaatullah</au><au>Khan, Gul Majid</au><au>Jan, Syed Umer</au><au>Shah, Kifayatullah</au><au>Hussain, Abid</au><au>Khan, Haroon</au><au>Khan, Kamran Ahmad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of novel diclofenac potassium controlled release tablets by wet granulation technique and the effect of co-excipients on in vitro drug release rates</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2012-01</date><risdate>2012</risdate><volume>25</volume><issue>1</issue><spage>161</spage><epage>168</epage><pages>161-168</pages><issn>1011-601X</issn><abstract>The aim of the present study was the formulation and evaluation of controlled release polymeric tablets of Diclofenac Potassium by wet granulation method for the release rate, release pattern and the mechanism involved in drug release. Formulations having three grades of polymer Ethocel (7P; 7FP, 10P, 10FP, 100P, 100FP) in several drugs to polymer ratios (10:3 and 10:1) were compressed into tablets using wet granulation method. Co-excipients were added to some selected formulations to investigate their enhancement effect on in vitro drug release patterns. In vitro drug release studies were performed using USP Method-1 (Rotating Basket method) and Phosphate buffer (pH 7.4) was used as a dissolution medium. The similarities and dissimilarities of release profiles of test formulations with reference standard were checked using f2 similarity factor and f1 dissimilarity factor. Mathematical/Kinetic models were employed to determine the release mechanism and drug release kinetics.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>22186325</pmid><tpages>8</tpages></addata></record> |
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| ispartof | Pakistan journal of pharmaceutical sciences, 2012-01, Vol.25 (1), p.161-168 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Cellulose - analogs & derivatives Cellulose - chemistry Chemistry, Pharmaceutical - methods Controlled release Controlled release preparations Delayed-Action Preparations - chemistry Diclofenac Diclofenac - administration & dosage Diclofenac - chemistry Drug Compounding - methods Drug Compounding - statistics & numerical data Drugs Excipients Excipients - chemistry Hydrogen-Ion Concentration In Vitro Techniques Kinetics Production processes Solubility Tablets - chemistry |
| title | Development of novel diclofenac potassium controlled release tablets by wet granulation technique and the effect of co-excipients on in vitro drug release rates |
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