Baicalein Suppresses the SOS Response System of Staphylococcus Aureus Induced by Ciprofloxacin
Numerous antibiotics can induce an SOS repair system in bacteria that leads to antibiotic-resistant mutation of the bacterium. Therefore, searching for drugs that can prevent the SOS response and thus improve the long-term viability of some antibiotics is important. In this study, we aimed to detect...
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| Veröffentlicht in: | Cellular physiology and biochemistry 2011-01, Vol.28 (5), p.1045-1050 |
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| container_title | Cellular physiology and biochemistry |
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| creator | Peng, Qing Zhou, Shuqin Yao, Fen Hou, Bing Huang, Yuanchun Hua, Dexing Zheng, Yanshan Qian, Yuanshu |
| description | Numerous antibiotics can induce an SOS repair system in bacteria that leads to antibiotic-resistant mutation of the bacterium. Therefore, searching for drugs that can prevent the SOS response and thus improve the long-term viability of some antibiotics is important. In this study, we aimed to detect the suppressive effects of baicalein on the SOS system and rifampin-resistant mutation in Staphylococcus aureus. We determined the reactive oxygen species (ROS) formation and intracellular ATP level in S. aureus with baicalein treatment to investigate the mechanisms involved in its effects on the SOS system. The results showed that baicalein was a potent inhibitor of the expression of the SOS genes RecA, LexA and SACOL1400. The rifampin-resistant mutation rate of S. aureus induced by ciprofloxacin was significantly reduced after treatment with baicalein. Treatment with baicalein led to a significant decrease in intracellular reactive oxygen species (ROS) formation and ATP level. Our findings indicate that baicalein may be an SOS-response inhibitor in S. aureus through inhibiting ROS formation and ATP production and may be used to prevent excessive mutation induced by antibiotics. |
| doi_str_mv | 10.1159/000335791 |
| format | Article |
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Therefore, searching for drugs that can prevent the SOS response and thus improve the long-term viability of some antibiotics is important. In this study, we aimed to detect the suppressive effects of baicalein on the SOS system and rifampin-resistant mutation in Staphylococcus aureus. We determined the reactive oxygen species (ROS) formation and intracellular ATP level in S. aureus with baicalein treatment to investigate the mechanisms involved in its effects on the SOS system. The results showed that baicalein was a potent inhibitor of the expression of the SOS genes RecA, LexA and SACOL1400. The rifampin-resistant mutation rate of S. aureus induced by ciprofloxacin was significantly reduced after treatment with baicalein. Treatment with baicalein led to a significant decrease in intracellular reactive oxygen species (ROS) formation and ATP level. Our findings indicate that baicalein may be an SOS-response inhibitor in S. aureus through inhibiting ROS formation and ATP production and may be used to prevent excessive mutation induced by antibiotics.</description><identifier>ISSN: 1015-8987</identifier><identifier>EISSN: 1421-9778</identifier><identifier>DOI: 10.1159/000335791</identifier><identifier>PMID: 22178954</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Adenosine Triphosphate - metabolism ; Anti-Infective Agents - pharmacology ; Antioxidants - pharmacology ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Ciprofloxacin - pharmacology ; Drug Resistance, Bacterial - drug effects ; Flavanones - pharmacology ; Microbial Sensitivity Tests ; Original Paper ; Reactive Oxygen Species - metabolism ; Rec A Recombinases - genetics ; Rec A Recombinases - metabolism ; Serine Endopeptidases - genetics ; Serine Endopeptidases - metabolism ; SOS Response (Genetics) - drug effects ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - metabolism</subject><ispartof>Cellular physiology and biochemistry, 2011-01, Vol.28 (5), p.1045-1050</ispartof><rights>2011 S. Karger AG, Basel</rights><rights>Copyright © 2011 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-1b69382562a08fb2ecbcb91d1b608d5226369bc87473f10207acb7060761afeb3</citedby><cites>FETCH-LOGICAL-c368t-1b69382562a08fb2ecbcb91d1b608d5226369bc87473f10207acb7060761afeb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22178954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Qing</creatorcontrib><creatorcontrib>Zhou, Shuqin</creatorcontrib><creatorcontrib>Yao, Fen</creatorcontrib><creatorcontrib>Hou, Bing</creatorcontrib><creatorcontrib>Huang, Yuanchun</creatorcontrib><creatorcontrib>Hua, Dexing</creatorcontrib><creatorcontrib>Zheng, Yanshan</creatorcontrib><creatorcontrib>Qian, Yuanshu</creatorcontrib><title>Baicalein Suppresses the SOS Response System of Staphylococcus Aureus Induced by Ciprofloxacin</title><title>Cellular physiology and biochemistry</title><addtitle>Cell Physiol Biochem</addtitle><description>Numerous antibiotics can induce an SOS repair system in bacteria that leads to antibiotic-resistant mutation of the bacterium. Therefore, searching for drugs that can prevent the SOS response and thus improve the long-term viability of some antibiotics is important. In this study, we aimed to detect the suppressive effects of baicalein on the SOS system and rifampin-resistant mutation in Staphylococcus aureus. We determined the reactive oxygen species (ROS) formation and intracellular ATP level in S. aureus with baicalein treatment to investigate the mechanisms involved in its effects on the SOS system. The results showed that baicalein was a potent inhibitor of the expression of the SOS genes RecA, LexA and SACOL1400. The rifampin-resistant mutation rate of S. aureus induced by ciprofloxacin was significantly reduced after treatment with baicalein. Treatment with baicalein led to a significant decrease in intracellular reactive oxygen species (ROS) formation and ATP level. Our findings indicate that baicalein may be an SOS-response inhibitor in S. aureus through inhibiting ROS formation and ATP production and may be used to prevent excessive mutation induced by antibiotics.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Ciprofloxacin - pharmacology</subject><subject>Drug Resistance, Bacterial - drug effects</subject><subject>Flavanones - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Original Paper</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Rec A Recombinases - genetics</subject><subject>Rec A Recombinases - metabolism</subject><subject>Serine Endopeptidases - genetics</subject><subject>Serine Endopeptidases - metabolism</subject><subject>SOS Response (Genetics) - drug effects</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - metabolism</subject><issn>1015-8987</issn><issn>1421-9778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkL1PwzAQxS0EolAY2BGyxIAYArbTxPbYRnxUqlREYCWynQsNpEmwE4n89xi1dGK6e3e_eyc9hM4ouaE0kreEkDCMuKR76IhOGA0k52Lf94RGgZCCj9Cxcx_ESy7ZIRoxRrmQ0eQIvc1UaVQFZY3Tvm0tOAcOdyvA6TLFz-DapnZeDK6DNW4KnHaqXQ1VYxpjeoenvQVf5nXeG8ixHnBStrYpquZbmbI-QQeFqhycbusYvd7fvSSPwWL5ME-mi8CEsegCqmMZChbFTBFRaAZGGy1p7udE5BFjcRhLbQSf8LCghBGujOYkJjymqgAdjtHVxtf__urBddm6dAaqStXQ9C6TlFFKxIR48npDGts4Z6HIWluulR0ySrLfNLNdmp692Lr2eg35jvyLzwPnG-BT2XewO2B3f_nvOnmabYiszYvwBzQBg_o</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Peng, Qing</creator><creator>Zhou, Shuqin</creator><creator>Yao, Fen</creator><creator>Hou, Bing</creator><creator>Huang, Yuanchun</creator><creator>Hua, Dexing</creator><creator>Zheng, Yanshan</creator><creator>Qian, Yuanshu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110101</creationdate><title>Baicalein Suppresses the SOS Response System of Staphylococcus Aureus Induced by Ciprofloxacin</title><author>Peng, Qing ; Zhou, Shuqin ; Yao, Fen ; Hou, Bing ; Huang, Yuanchun ; Hua, Dexing ; Zheng, Yanshan ; Qian, Yuanshu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-1b69382562a08fb2ecbcb91d1b608d5226369bc87473f10207acb7060761afeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Ciprofloxacin - pharmacology</topic><topic>Drug Resistance, Bacterial - drug effects</topic><topic>Flavanones - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Original Paper</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Rec A Recombinases - genetics</topic><topic>Rec A Recombinases - metabolism</topic><topic>Serine Endopeptidases - genetics</topic><topic>Serine Endopeptidases - metabolism</topic><topic>SOS Response (Genetics) - drug effects</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Qing</creatorcontrib><creatorcontrib>Zhou, Shuqin</creatorcontrib><creatorcontrib>Yao, Fen</creatorcontrib><creatorcontrib>Hou, Bing</creatorcontrib><creatorcontrib>Huang, Yuanchun</creatorcontrib><creatorcontrib>Hua, Dexing</creatorcontrib><creatorcontrib>Zheng, Yanshan</creatorcontrib><creatorcontrib>Qian, Yuanshu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Qing</au><au>Zhou, Shuqin</au><au>Yao, Fen</au><au>Hou, Bing</au><au>Huang, Yuanchun</au><au>Hua, Dexing</au><au>Zheng, Yanshan</au><au>Qian, Yuanshu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Baicalein Suppresses the SOS Response System of Staphylococcus Aureus Induced by Ciprofloxacin</atitle><jtitle>Cellular physiology and biochemistry</jtitle><addtitle>Cell Physiol Biochem</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>28</volume><issue>5</issue><spage>1045</spage><epage>1050</epage><pages>1045-1050</pages><issn>1015-8987</issn><eissn>1421-9778</eissn><abstract>Numerous antibiotics can induce an SOS repair system in bacteria that leads to antibiotic-resistant mutation of the bacterium. Therefore, searching for drugs that can prevent the SOS response and thus improve the long-term viability of some antibiotics is important. In this study, we aimed to detect the suppressive effects of baicalein on the SOS system and rifampin-resistant mutation in Staphylococcus aureus. We determined the reactive oxygen species (ROS) formation and intracellular ATP level in S. aureus with baicalein treatment to investigate the mechanisms involved in its effects on the SOS system. The results showed that baicalein was a potent inhibitor of the expression of the SOS genes RecA, LexA and SACOL1400. The rifampin-resistant mutation rate of S. aureus induced by ciprofloxacin was significantly reduced after treatment with baicalein. Treatment with baicalein led to a significant decrease in intracellular reactive oxygen species (ROS) formation and ATP level. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adenosine Triphosphate - metabolism Anti-Infective Agents - pharmacology Antioxidants - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism Ciprofloxacin - pharmacology Drug Resistance, Bacterial - drug effects Flavanones - pharmacology Microbial Sensitivity Tests Original Paper Reactive Oxygen Species - metabolism Rec A Recombinases - genetics Rec A Recombinases - metabolism Serine Endopeptidases - genetics Serine Endopeptidases - metabolism SOS Response (Genetics) - drug effects Staphylococcus aureus - drug effects Staphylococcus aureus - metabolism |
| title | Baicalein Suppresses the SOS Response System of Staphylococcus Aureus Induced by Ciprofloxacin |
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