The Accuracy of Platelet Counting in Thrombocytopenic Blood Samples Distributed by the UK National External Quality Assessment Scheme for General Haematology
A knowledge of the limitations of automated platelet counting is essential for the effective care of thrombocytopenic patients and management of platelet stocks for transfusion. For this study, 29 external quality assessment specimen pools with platelet counts between 5 and 64 × 10(9)/L were distrib...
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| Veröffentlicht in: | American journal of clinical pathology 2012, Vol.137 (1), p.65-74 |
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| container_title | American journal of clinical pathology |
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| creator | DE LA SALLE, Barbara J MCTAGGART, Paul N BRIGGS, Carol HARRISON, Paul DORE, Caroline J LONGAIR, Ian MACHIN, Samuel J HYDE, Keith |
| description | A knowledge of the limitations of automated platelet counting is essential for the effective care of thrombocytopenic patients and management of platelet stocks for transfusion. For this study, 29 external quality assessment specimen pools with platelet counts between 5 and 64 × 10(9)/L were distributed to more than 1,100 users of 23 different hematology analyzer models. The same specimen pools were analyzed by the international reference method (IRM) for platelet counting at 3 reference centers. The IRM values were on average lower than the all-methods median values returned by the automated analyzers. The majority (~67%) of the automated analyzer results overestimated the platelet count compared with the IRM, with significant differences in 16.5% of cases. Performance differed between analyzer models. The observed differences may depend in part on the nature of the survey material and analyzer technology, but the findings have implications for the interpretation of platelet counts at levels of clinical decision making. |
| doi_str_mv | 10.1309/AJCP86JMBFUCFCXA |
| format | Article |
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For this study, 29 external quality assessment specimen pools with platelet counts between 5 and 64 × 10(9)/L were distributed to more than 1,100 users of 23 different hematology analyzer models. The same specimen pools were analyzed by the international reference method (IRM) for platelet counting at 3 reference centers. The IRM values were on average lower than the all-methods median values returned by the automated analyzers. The majority (~67%) of the automated analyzer results overestimated the platelet count compared with the IRM, with significant differences in 16.5% of cases. Performance differed between analyzer models. The observed differences may depend in part on the nature of the survey material and analyzer technology, but the findings have implications for the interpretation of platelet counts at levels of clinical decision making.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/AJCP86JMBFUCFCXA</identifier><identifier>PMID: 22180479</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Biological and medical sciences ; Blood Platelets - cytology ; Hematologic and hematopoietic diseases ; Humans ; Internationality ; Investigative techniques, diagnostic techniques (general aspects) ; Laboratories - standards ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. 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For this study, 29 external quality assessment specimen pools with platelet counts between 5 and 64 × 10(9)/L were distributed to more than 1,100 users of 23 different hematology analyzer models. The same specimen pools were analyzed by the international reference method (IRM) for platelet counting at 3 reference centers. The IRM values were on average lower than the all-methods median values returned by the automated analyzers. The majority (~67%) of the automated analyzer results overestimated the platelet count compared with the IRM, with significant differences in 16.5% of cases. Performance differed between analyzer models. The observed differences may depend in part on the nature of the survey material and analyzer technology, but the findings have implications for the interpretation of platelet counts at levels of clinical decision making.</description><subject>Biological and medical sciences</subject><subject>Blood Platelets - cytology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Internationality</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Laboratories - standards</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Miscellaneous investigative techniques</topic><topic>Platelet Count - instrumentation</topic><topic>Platelet Count - methods</topic><topic>Platelet Count - standards</topic><topic>Platelet diseases and coagulopathies</topic><topic>Quality Assurance, Health Care - standards</topic><topic>Reference Standards</topic><topic>Reproducibility of Results</topic><topic>United Kingdom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE LA SALLE, Barbara J</creatorcontrib><creatorcontrib>MCTAGGART, Paul N</creatorcontrib><creatorcontrib>BRIGGS, Carol</creatorcontrib><creatorcontrib>HARRISON, Paul</creatorcontrib><creatorcontrib>DORE, Caroline J</creatorcontrib><creatorcontrib>LONGAIR, Ian</creatorcontrib><creatorcontrib>MACHIN, Samuel J</creatorcontrib><creatorcontrib>HYDE, Keith</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE LA SALLE, Barbara J</au><au>MCTAGGART, Paul N</au><au>BRIGGS, Carol</au><au>HARRISON, Paul</au><au>DORE, Caroline J</au><au>LONGAIR, Ian</au><au>MACHIN, Samuel J</au><au>HYDE, Keith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Accuracy of Platelet Counting in Thrombocytopenic Blood Samples Distributed by the UK National External Quality Assessment Scheme for General Haematology</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2012</date><risdate>2012</risdate><volume>137</volume><issue>1</issue><spage>65</spage><epage>74</epage><pages>65-74</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>A knowledge of the limitations of automated platelet counting is essential for the effective care of thrombocytopenic patients and management of platelet stocks for transfusion. For this study, 29 external quality assessment specimen pools with platelet counts between 5 and 64 × 10(9)/L were distributed to more than 1,100 users of 23 different hematology analyzer models. The same specimen pools were analyzed by the international reference method (IRM) for platelet counting at 3 reference centers. The IRM values were on average lower than the all-methods median values returned by the automated analyzers. The majority (~67%) of the automated analyzer results overestimated the platelet count compared with the IRM, with significant differences in 16.5% of cases. Performance differed between analyzer models. The observed differences may depend in part on the nature of the survey material and analyzer technology, but the findings have implications for the interpretation of platelet counts at levels of clinical decision making.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>22180479</pmid><doi>10.1309/AJCP86JMBFUCFCXA</doi><tpages>10</tpages></addata></record> |
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| ispartof | American journal of clinical pathology, 2012, Vol.137 (1), p.65-74 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Blood Platelets - cytology Hematologic and hematopoietic diseases Humans Internationality Investigative techniques, diagnostic techniques (general aspects) Laboratories - standards Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Platelet Count - instrumentation Platelet Count - methods Platelet Count - standards Platelet diseases and coagulopathies Quality Assurance, Health Care - standards Reference Standards Reproducibility of Results United Kingdom |
| title | The Accuracy of Platelet Counting in Thrombocytopenic Blood Samples Distributed by the UK National External Quality Assessment Scheme for General Haematology |
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