NRP-1/CD304 Expression in Acute Leukemia: A Potential Marker for Minimal Residual Disease Detection in Precursor B-Cell Acute Lymphoblastic Leukemia
Neuropilin-1 (NRP-1)/CD304 is a marker for plasmacytoid dendritic cells. We determined the distribution of NRP-1/CD304 expression on normal hematopoietic cells and in 167 acute leukemias by flow cytometry. NRP-1/CD304 surface expression was frequent in precursor B-cell acute lymphoblastic leukemia (...
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| Veröffentlicht in: | American journal of clinical pathology 2012, Vol.137 (1), p.39-50 |
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| creator | MEYERSON, Howard J BLIDARU, Georgetta EDINGER, Alison OSEI, Ebenezer SCHWEITZER, Karen PINGFU FU LINDA HO |
| description | Neuropilin-1 (NRP-1)/CD304 is a marker for plasmacytoid dendritic cells. We determined the distribution of NRP-1/CD304 expression on normal hematopoietic cells and in 167 acute leukemias by flow cytometry. NRP-1/CD304 surface expression was frequent in precursor B-cell acute lymphoblastic leukemia (36/51 [71%]) and uncommon in acute myeloid leukemia (22.9%). In acute myeloid leukemia, expression was noted in all (4/4) acute myeloid leukemias with the M4eo subtype and in 50% of specimens (6/12) with complex cytogenetics. On hematopoietic cells, NRP-1/CD304 was expressed on normal erythroid progenitors, plasma cells, and B-cell progenitors, as well as plasmacytoid dendritic cells. Expression was not consistently detected on other hematopoietic cell types. Owing to this distribution of expression, the detection of NRP-1/CD304 alone on a hematopoietic cell cannot be used to determine plasmacytoid dendritic cell differentiation. Finally, we show that NRP-1/CD304 is overexpressed in 30% of precursor B-cell acute lymphoblastic leukemia samples compared with normal B-cell progenitors, allowing for its potential use as a marker for the detection of minimal residual disease. |
| doi_str_mv | 10.1309/AJCP6VDBL4BRXRQA |
| format | Article |
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We determined the distribution of NRP-1/CD304 expression on normal hematopoietic cells and in 167 acute leukemias by flow cytometry. NRP-1/CD304 surface expression was frequent in precursor B-cell acute lymphoblastic leukemia (36/51 [71%]) and uncommon in acute myeloid leukemia (22.9%). In acute myeloid leukemia, expression was noted in all (4/4) acute myeloid leukemias with the M4eo subtype and in 50% of specimens (6/12) with complex cytogenetics. On hematopoietic cells, NRP-1/CD304 was expressed on normal erythroid progenitors, plasma cells, and B-cell progenitors, as well as plasmacytoid dendritic cells. Expression was not consistently detected on other hematopoietic cell types. Owing to this distribution of expression, the detection of NRP-1/CD304 alone on a hematopoietic cell cannot be used to determine plasmacytoid dendritic cell differentiation. Finally, we show that NRP-1/CD304 is overexpressed in 30% of precursor B-cell acute lymphoblastic leukemia samples compared with normal B-cell progenitors, allowing for its potential use as a marker for the detection of minimal residual disease.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/AJCP6VDBL4BRXRQA</identifier><identifier>PMID: 22180477</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Bone Marrow Cells - cytology ; Bone Marrow Cells - metabolism ; Dendritic Cells - metabolism ; Dendritic Cells - pathology ; Erythroblasts - metabolism ; Erythroblasts - pathology ; Flow Cytometry ; Hematologic and hematopoietic diseases ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Leukemia, Myeloid, Acute - diagnosis ; Leukemia, Myeloid, Acute - metabolism ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Neoplasm, Residual - diagnosis ; Neoplasm, Residual - metabolism ; Neuropilin-1 - metabolism ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Plasma Cells - metabolism ; Plasma Cells - pathology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism ; Precursor Cells, B-Lymphoid - metabolism ; Precursor Cells, B-Lymphoid - pathology</subject><ispartof>American journal of clinical pathology, 2012, Vol.137 (1), p.39-50</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Society for Clinical Pathology Jan 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c238t-c522d37b34912eed8dca49ab3f8e693e31310a6631fb12c346459696303c4c683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25604878$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22180477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MEYERSON, Howard J</creatorcontrib><creatorcontrib>BLIDARU, Georgetta</creatorcontrib><creatorcontrib>EDINGER, Alison</creatorcontrib><creatorcontrib>OSEI, Ebenezer</creatorcontrib><creatorcontrib>SCHWEITZER, Karen</creatorcontrib><creatorcontrib>PINGFU FU</creatorcontrib><creatorcontrib>LINDA HO</creatorcontrib><title>NRP-1/CD304 Expression in Acute Leukemia: A Potential Marker for Minimal Residual Disease Detection in Precursor B-Cell Acute Lymphoblastic Leukemia</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Neuropilin-1 (NRP-1)/CD304 is a marker for plasmacytoid dendritic cells. We determined the distribution of NRP-1/CD304 expression on normal hematopoietic cells and in 167 acute leukemias by flow cytometry. NRP-1/CD304 surface expression was frequent in precursor B-cell acute lymphoblastic leukemia (36/51 [71%]) and uncommon in acute myeloid leukemia (22.9%). In acute myeloid leukemia, expression was noted in all (4/4) acute myeloid leukemias with the M4eo subtype and in 50% of specimens (6/12) with complex cytogenetics. On hematopoietic cells, NRP-1/CD304 was expressed on normal erythroid progenitors, plasma cells, and B-cell progenitors, as well as plasmacytoid dendritic cells. Expression was not consistently detected on other hematopoietic cell types. Owing to this distribution of expression, the detection of NRP-1/CD304 alone on a hematopoietic cell cannot be used to determine plasmacytoid dendritic cell differentiation. Finally, we show that NRP-1/CD304 is overexpressed in 30% of precursor B-cell acute lymphoblastic leukemia samples compared with normal B-cell progenitors, allowing for its potential use as a marker for the detection of minimal residual disease.</description><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Bone Marrow Cells - cytology</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Dendritic Cells - metabolism</subject><subject>Dendritic Cells - pathology</subject><subject>Erythroblasts - metabolism</subject><subject>Erythroblasts - pathology</subject><subject>Flow Cytometry</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukemia, Myeloid, Acute - diagnosis</subject><subject>Leukemia, Myeloid, Acute - metabolism</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Neoplasm, Residual - diagnosis</subject><subject>Neoplasm, Residual - metabolism</subject><subject>Neuropilin-1 - metabolism</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Neoplasm, Residual - diagnosis</topic><topic>Neoplasm, Residual - metabolism</topic><topic>Neuropilin-1 - metabolism</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Plasma Cells - metabolism</topic><topic>Plasma Cells - pathology</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism</topic><topic>Precursor Cells, B-Lymphoid - metabolism</topic><topic>Precursor Cells, B-Lymphoid - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MEYERSON, Howard J</creatorcontrib><creatorcontrib>BLIDARU, Georgetta</creatorcontrib><creatorcontrib>EDINGER, Alison</creatorcontrib><creatorcontrib>OSEI, Ebenezer</creatorcontrib><creatorcontrib>SCHWEITZER, Karen</creatorcontrib><creatorcontrib>PINGFU FU</creatorcontrib><creatorcontrib>LINDA HO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MEYERSON, Howard J</au><au>BLIDARU, Georgetta</au><au>EDINGER, Alison</au><au>OSEI, Ebenezer</au><au>SCHWEITZER, Karen</au><au>PINGFU FU</au><au>LINDA HO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NRP-1/CD304 Expression in Acute Leukemia: A Potential Marker for Minimal Residual Disease Detection in Precursor B-Cell Acute Lymphoblastic Leukemia</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2012</date><risdate>2012</risdate><volume>137</volume><issue>1</issue><spage>39</spage><epage>50</epage><pages>39-50</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>Neuropilin-1 (NRP-1)/CD304 is a marker for plasmacytoid dendritic cells. We determined the distribution of NRP-1/CD304 expression on normal hematopoietic cells and in 167 acute leukemias by flow cytometry. NRP-1/CD304 surface expression was frequent in precursor B-cell acute lymphoblastic leukemia (36/51 [71%]) and uncommon in acute myeloid leukemia (22.9%). In acute myeloid leukemia, expression was noted in all (4/4) acute myeloid leukemias with the M4eo subtype and in 50% of specimens (6/12) with complex cytogenetics. On hematopoietic cells, NRP-1/CD304 was expressed on normal erythroid progenitors, plasma cells, and B-cell progenitors, as well as plasmacytoid dendritic cells. Expression was not consistently detected on other hematopoietic cell types. Owing to this distribution of expression, the detection of NRP-1/CD304 alone on a hematopoietic cell cannot be used to determine plasmacytoid dendritic cell differentiation. Finally, we show that NRP-1/CD304 is overexpressed in 30% of precursor B-cell acute lymphoblastic leukemia samples compared with normal B-cell progenitors, allowing for its potential use as a marker for the detection of minimal residual disease.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>22180477</pmid><doi>10.1309/AJCP6VDBL4BRXRQA</doi><tpages>12</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Biomarkers, Tumor - metabolism Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Dendritic Cells - metabolism Dendritic Cells - pathology Erythroblasts - metabolism Erythroblasts - pathology Flow Cytometry Hematologic and hematopoietic diseases Humans Investigative techniques, diagnostic techniques (general aspects) Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Neoplasm, Residual - diagnosis Neoplasm, Residual - metabolism Neuropilin-1 - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Plasma Cells - metabolism Plasma Cells - pathology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cells, B-Lymphoid - metabolism Precursor Cells, B-Lymphoid - pathology |
| title | NRP-1/CD304 Expression in Acute Leukemia: A Potential Marker for Minimal Residual Disease Detection in Precursor B-Cell Acute Lymphoblastic Leukemia |
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