The efficiency of male fertility restoration is dependent on the recovery kinetics of spermatogonial stem cells after cytotoxic treatment with busulfan in mice

BACKGROUND Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis and represent a crucial resource for male fertility restoration. It has not been well documented, however, whether the recovery of SSC population size after cytotoxic damage associates with the kinetics of male fertili...

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Veröffentlicht in:	Human reproduction (Oxford) 2012-01, Vol.27 (1), p.44-53
Hauptverfasser:	Zohni, K., Zhang, X., Tan, S.L., Chan, P., Nagano, M.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Busulfan - therapeutic use Cytotoxins - therapeutic use Dose-Response Relationship, Drug Gynecology. Andrology. Obstetrics Infertility, Male - genetics Infertility, Male - therapy Kinetics Male Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Neuroglia - cytology Sperm Count Spermatogonia - metabolism Stem Cells - cytology Testis - drug effects Testis - pathology
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