Protective effect of folic acid on cyclosporine-induced bone loss in rats
Summary Hyperhomocysteinemia is seen in patients with decreased bone mineral density. Cyclosporine can cause alveolar bone loss and osteopenia. It is also associated with elevated serum homocysteine levels. We aimed to investigate the effect of cyclosporine on serum homocysteine level, bone volume,...
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| Veröffentlicht in: | Transplant international 2012-01, Vol.25 (1), p.127-133 |
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| creator | Mohammadi, Alireza Omrani, Layla Omrani, Ladan R. Kiani, Farin Eshraghian, Ahad Azizi, Zabihallah Omrani, Gholamhossein R. |
| description | Summary
Hyperhomocysteinemia is seen in patients with decreased bone mineral density. Cyclosporine can cause alveolar bone loss and osteopenia. It is also associated with elevated serum homocysteine levels. We aimed to investigate the effect of cyclosporine on serum homocysteine level, bone volume, and bone density, and determine whether folic acid had a protective effect against bone loss. In an experimental study, 40 male Sprague–Dawley rats were randomly assigned to five groups and received dietary supplementation for 6 weeks with olive oil (Group A), cyclosporine (Group B), folic acid (Group C), and cyclosporine plus folic acid (Group D), or no supplementation (Group F, control). Serum homocysteine, calcium, alkaline phosphatase, total bone volume, periodontal ligament volume, and volume density of bone were compared between groups. Mean serum homocysteine level (10.84 ± 0.93 μmol/l) was significantly higher in group B (cyclosporine supplementation) compared with the other groups (P = 0.001). Mean total mandibular volume was 46.3 ± 13.6 mm3 in rats treated with cyclosporine, 80.4 ± 15.70 mm3 in rats treated with folic acid (P = 0.004), and 73.9 ± 21.3 mm3 in rats treated with cyclosporine plus folic acid (P = 0.028). In our experimental model, cyclosporine increased serum homocysteine levels and decreased bone volume and density. Folic acid may have a preventive role against bone loss in rats treated with cyclosporine. |
| doi_str_mv | 10.1111/j.1432-2277.2011.01375.x |
| format | Article |
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Hyperhomocysteinemia is seen in patients with decreased bone mineral density. Cyclosporine can cause alveolar bone loss and osteopenia. It is also associated with elevated serum homocysteine levels. We aimed to investigate the effect of cyclosporine on serum homocysteine level, bone volume, and bone density, and determine whether folic acid had a protective effect against bone loss. In an experimental study, 40 male Sprague–Dawley rats were randomly assigned to five groups and received dietary supplementation for 6 weeks with olive oil (Group A), cyclosporine (Group B), folic acid (Group C), and cyclosporine plus folic acid (Group D), or no supplementation (Group F, control). Serum homocysteine, calcium, alkaline phosphatase, total bone volume, periodontal ligament volume, and volume density of bone were compared between groups. Mean serum homocysteine level (10.84 ± 0.93 μmol/l) was significantly higher in group B (cyclosporine supplementation) compared with the other groups (P = 0.001). Mean total mandibular volume was 46.3 ± 13.6 mm3 in rats treated with cyclosporine, 80.4 ± 15.70 mm3 in rats treated with folic acid (P = 0.004), and 73.9 ± 21.3 mm3 in rats treated with cyclosporine plus folic acid (P = 0.028). In our experimental model, cyclosporine increased serum homocysteine levels and decreased bone volume and density. Folic acid may have a preventive role against bone loss in rats treated with cyclosporine.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/j.1432-2277.2011.01375.x</identifier><identifier>PMID: 22039919</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animal Feed ; Animals ; bone density ; Bone Density - drug effects ; bone volume ; cyclosporine ; Cyclosporine - adverse effects ; Cyclosporine - pharmacology ; folic acid ; Folic Acid - metabolism ; Folic Acid - pharmacology ; homocysteine ; Homocysteine - blood ; Immunosuppressive Agents - adverse effects ; Immunosuppressive Agents - pharmacology ; Male ; Models, Biological ; Models, Statistical ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Transplant international, 2012-01, Vol.25 (1), p.127-133</ispartof><rights>2011 The Authors. Transplant International © 2011 European Society for Organ Transplantation</rights><rights>2011 The Authors. Transplant International © 2011 European Society for Organ Transplantation.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4515-6cb2cc4ba3ae9349caeab7c7e558f83babf143aa86072196de69e2a9cb0f884c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1432-2277.2011.01375.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1432-2277.2011.01375.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22039919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohammadi, Alireza</creatorcontrib><creatorcontrib>Omrani, Layla</creatorcontrib><creatorcontrib>Omrani, Ladan R.</creatorcontrib><creatorcontrib>Kiani, Farin</creatorcontrib><creatorcontrib>Eshraghian, Ahad</creatorcontrib><creatorcontrib>Azizi, Zabihallah</creatorcontrib><creatorcontrib>Omrani, Gholamhossein R.</creatorcontrib><title>Protective effect of folic acid on cyclosporine-induced bone loss in rats</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Summary
Hyperhomocysteinemia is seen in patients with decreased bone mineral density. Cyclosporine can cause alveolar bone loss and osteopenia. It is also associated with elevated serum homocysteine levels. We aimed to investigate the effect of cyclosporine on serum homocysteine level, bone volume, and bone density, and determine whether folic acid had a protective effect against bone loss. In an experimental study, 40 male Sprague–Dawley rats were randomly assigned to five groups and received dietary supplementation for 6 weeks with olive oil (Group A), cyclosporine (Group B), folic acid (Group C), and cyclosporine plus folic acid (Group D), or no supplementation (Group F, control). Serum homocysteine, calcium, alkaline phosphatase, total bone volume, periodontal ligament volume, and volume density of bone were compared between groups. Mean serum homocysteine level (10.84 ± 0.93 μmol/l) was significantly higher in group B (cyclosporine supplementation) compared with the other groups (P = 0.001). Mean total mandibular volume was 46.3 ± 13.6 mm3 in rats treated with cyclosporine, 80.4 ± 15.70 mm3 in rats treated with folic acid (P = 0.004), and 73.9 ± 21.3 mm3 in rats treated with cyclosporine plus folic acid (P = 0.028). In our experimental model, cyclosporine increased serum homocysteine levels and decreased bone volume and density. Folic acid may have a preventive role against bone loss in rats treated with cyclosporine.</description><subject>Animal Feed</subject><subject>Animals</subject><subject>bone density</subject><subject>Bone Density - drug effects</subject><subject>bone volume</subject><subject>cyclosporine</subject><subject>Cyclosporine - adverse effects</subject><subject>Cyclosporine - pharmacology</subject><subject>folic acid</subject><subject>Folic Acid - metabolism</subject><subject>Folic Acid - pharmacology</subject><subject>homocysteine</subject><subject>Homocysteine - blood</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Models, Statistical</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtP3DAUhS0EKlPgLyBLLFgl9SOJ40UXaESnUyH6EAiJzZXj3EieZuIhTtqZf1-nA7PAG1u-370-PocQylnK4_q0SnkmRSKEUqlgnKeMS5Wn2yMyOxSOyYxpmSWsVNkp-RjCijEmypx9IKdCMKk11zOy_NH7Ae3g_iDFpokn6hva-NZZaqyrqe-o3dnWh43vXYeJ6-rRYk0r3yGN14G6jvZmCOfkpDFtwIvX_Yw8frl9mH9N7r4vlvObu8RmOc-TwlbC2qwy0mCUp61BUymrMM_LppSVqZr4BWPKginBdVFjoVEYbSvWlGVm5Rm53s_d9P5lxDDA2gWLbWs69GMAzQVnWggeyat35MqPfRfFAVdFUWoVTYvU5Ss1VmusYdO7tel38OZRBD7vgb-uxd2hzhlMWcAKJsthshymLOB_FrCFh19Lvn8g2fe7MOD20G_631BMCuDpfgHfip_y6f55Dkz-A98Mi1U</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Mohammadi, Alireza</creator><creator>Omrani, Layla</creator><creator>Omrani, Ladan R.</creator><creator>Kiani, Farin</creator><creator>Eshraghian, Ahad</creator><creator>Azizi, Zabihallah</creator><creator>Omrani, Gholamhossein R.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>Protective effect of folic acid on cyclosporine-induced bone loss in rats</title><author>Mohammadi, Alireza ; Omrani, Layla ; Omrani, Ladan R. ; Kiani, Farin ; Eshraghian, Ahad ; Azizi, Zabihallah ; Omrani, Gholamhossein R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4515-6cb2cc4ba3ae9349caeab7c7e558f83babf143aa86072196de69e2a9cb0f884c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal Feed</topic><topic>Animals</topic><topic>bone density</topic><topic>Bone Density - drug effects</topic><topic>bone volume</topic><topic>cyclosporine</topic><topic>Cyclosporine - adverse effects</topic><topic>Cyclosporine - pharmacology</topic><topic>folic acid</topic><topic>Folic Acid - metabolism</topic><topic>Folic Acid - pharmacology</topic><topic>homocysteine</topic><topic>Homocysteine - blood</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Models, Statistical</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohammadi, Alireza</creatorcontrib><creatorcontrib>Omrani, Layla</creatorcontrib><creatorcontrib>Omrani, Ladan R.</creatorcontrib><creatorcontrib>Kiani, Farin</creatorcontrib><creatorcontrib>Eshraghian, Ahad</creatorcontrib><creatorcontrib>Azizi, Zabihallah</creatorcontrib><creatorcontrib>Omrani, Gholamhossein R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohammadi, Alireza</au><au>Omrani, Layla</au><au>Omrani, Ladan R.</au><au>Kiani, Farin</au><au>Eshraghian, Ahad</au><au>Azizi, Zabihallah</au><au>Omrani, Gholamhossein R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of folic acid on cyclosporine-induced bone loss in rats</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2012-01</date><risdate>2012</risdate><volume>25</volume><issue>1</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Summary
Hyperhomocysteinemia is seen in patients with decreased bone mineral density. Cyclosporine can cause alveolar bone loss and osteopenia. It is also associated with elevated serum homocysteine levels. We aimed to investigate the effect of cyclosporine on serum homocysteine level, bone volume, and bone density, and determine whether folic acid had a protective effect against bone loss. In an experimental study, 40 male Sprague–Dawley rats were randomly assigned to five groups and received dietary supplementation for 6 weeks with olive oil (Group A), cyclosporine (Group B), folic acid (Group C), and cyclosporine plus folic acid (Group D), or no supplementation (Group F, control). Serum homocysteine, calcium, alkaline phosphatase, total bone volume, periodontal ligament volume, and volume density of bone were compared between groups. Mean serum homocysteine level (10.84 ± 0.93 μmol/l) was significantly higher in group B (cyclosporine supplementation) compared with the other groups (P = 0.001). Mean total mandibular volume was 46.3 ± 13.6 mm3 in rats treated with cyclosporine, 80.4 ± 15.70 mm3 in rats treated with folic acid (P = 0.004), and 73.9 ± 21.3 mm3 in rats treated with cyclosporine plus folic acid (P = 0.028). In our experimental model, cyclosporine increased serum homocysteine levels and decreased bone volume and density. Folic acid may have a preventive role against bone loss in rats treated with cyclosporine.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22039919</pmid><doi>10.1111/j.1432-2277.2011.01375.x</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library All Journals |
| subjects | Animal Feed Animals bone density Bone Density - drug effects bone volume cyclosporine Cyclosporine - adverse effects Cyclosporine - pharmacology folic acid Folic Acid - metabolism Folic Acid - pharmacology homocysteine Homocysteine - blood Immunosuppressive Agents - adverse effects Immunosuppressive Agents - pharmacology Male Models, Biological Models, Statistical Rats Rats, Sprague-Dawley |
| title | Protective effect of folic acid on cyclosporine-induced bone loss in rats |
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