Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle

In the present study, we evaluated how a pharmacologically induced phenotype shift in dystrophic skeletal muscle would affect subsequent intracellular signaling in response to a complementary, adaptive physiological stimulus. mdx mice were treated with the AMP-activated protein kinase (AMPK) activat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2012-01, Vol.302 (1), p.C110-C121
Hauptverfasser:	Ljubicic, Vladimir, Khogali, Shiemaa, Renaud, Jean-Marc, Jasmin, Bernard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - drug effects Adaptation, Physiological - genetics Adaptation, Physiological - physiology Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP-Activated Protein Kinases - administration & dosage Animals Disease Models, Animal Gene expression Genotype & phenotype Kinases Mice Mice, Inbred C57BL Mice, Inbred mdx Mice, Transgenic Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Muscular Dystrophy, Duchenne - physiopathology Musculoskeletal system Physical Conditioning, Animal - methods Ribonucleotides - pharmacology Rodents Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!