Prognostic implications of genetic aberrations in acute myelogenous leukemia with normal cytogenetics

Acute myelogenous leukemia (AML) is a genetically heterogeneous disease in which somatic mutations, that disturb cellular growth, proliferation, and differentiation, accumulate in hematopoietic progenitor cells. Cytogenetic findings, at diagnosis, have been proven to be one of the most important pro...

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Veröffentlicht in:	American journal of hematology 2012-01, Vol.87 (1), p.69-77
Hauptverfasser:	Ghanem, Hady, Tank, Niki, Tabbara, Imad A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - genetics Chromosome Aberrations Cytogenetic Analysis Gene Expression Regulation, Leukemic Hematologic and hematopoietic diseases Hematology Humans Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mutation Neoplasm, Residual - genetics Prognosis
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