Carbon monoxide inhibits apoptosis during cold storage and protects kidney grafts donated after cardiac death

Summary Ischemia/reperfusion (I/R) injury remains as a serious deleterious factor in kidney transplantation (KTx). We hypothesized that carbon monoxide (CO), an endogenous potent cytoprotective molecule, inhibits hypothermia‐induced apoptosis of kidney grafts. Using the rat KTx model mimicking the c...

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Veröffentlicht in:	Transplant international 2012-01, Vol.25 (1), p.107-117
Hauptverfasser:	Ozaki, Kikumi S., Yoshida, Junichi, Ueki, Shinya, Pettigrew, Gaetan L., Ghonem, Nisanne, Sico, Rita M., Lee, Lung-Yi, Shapiro, Ron, Lakkis, Fadi G., Pacheco-Silva, Alvaro, Murase, Noriko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - pharmacology Allopurinol - pharmacology Animals Apoptosis Carbon monoxide Carbon Monoxide - pharmacology Cold Temperature Cytosol - metabolism Death donation after cardiac death extended criteria donor Glutathione - pharmacology Humans Inflammation Insulin - pharmacology Ischemia ischemia/reperfusion injury Kidney - metabolism kidney transplantation Kidney Transplantation - methods Kidneys Male Organ Preservation - methods Organ Preservation Solutions - pharmacology Raffinose - pharmacology Rats Rats, Inbred Lew Reperfusion Injury RNA, Messenger - metabolism Rodents Transplants & implants Treatment Outcome
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