Development and validation of a bioanalytical LC–MS method for the quantification of GHRP-6 in human plasma

► A quantitative method for GHRP-6 in human plasma was developed and fully validated. ► 13C-labeled Alanine GHRP-6 as internal standard allowed relative quantification. ► Sample cleanup guaranteed no plasma interferences during LC–MS analysis. ► GHRP-6 is highly stable in human plasma. ► Established...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2012-02, Vol.60, p.19-25
Hauptverfasser:	Gil, Jeovanis, Cabrales, Ania, Reyes, Osvaldo, Morera, Vivian, Betancourt, Lázaro, Sánchez, Aniel, García, Gerardo, Moya, Galina, Padrón, Gabriel, Besada, Vladimir, González, Luis Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	acetone Alanine Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences blood proteins Carbon Isotopes clinical trials cold Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry - methods General pharmacology GHRP-6 guidelines Humans Internal standard ischemia kidneys LC–MS Limit of Detection liver Medical sciences Method validation Oligopeptides - analysis Oligopeptides - blood Pharmacology. Drug treatments Plant Proteins Plasma quality control Reference Standards somatotropin spectrometers Transcription Factors viability volunteers
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